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公开(公告)号：US20110065726A1
公开(公告)日：2011-03-17
申请号：US12376057
申请日：2007-07-31
Applicant: Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
Inventor： Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
IPC: C07D401/12 , A61P35/04 , A61K31/44 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/506 , C07D413/12 , C07D417/12
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US08546336B2
公开(公告)日：2013-10-01
申请号：US13606676
申请日：2012-09-07
Applicant: Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: A61K38/00
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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![(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses](/abs-image/US/2013/10/08/US08552003B2/abs.jpg.150x150.jpg)
3.发明授权(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses 有权（S）-N - （（S）-1-环己基-2 - {（S）-2- [4-4-（4-氟苯甲酰基） - 噻唑-2-基]吡咯烷-1-基} -2- 氧代乙基）-2-甲基氨基 - 丙酰胺或其药学上可接受的盐及其用途公开(公告)号：US08552003B2
公开(公告)日：2013-10-08
申请号：US12376057
申请日：2007-07-31
Applicant: Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: A01N43/54
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20130005663A1
公开(公告)日：2013-01-03
申请号：US13606676
申请日：2012-09-07
Applicant: Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
Inventor： Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US08338440B2
公开(公告)日：2012-12-25
申请号：US13456274
申请日：2012-04-26
Applicant: Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/427 , A61K31/4245 , A61K31/422 , A61K31/435 , A61K31/40 , A61K31/506 , A61K31/41
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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Patent Agency Ranking
公开(公告)号：US08207183B2
公开(公告)日：2012-06-26
申请号：US13178946
申请日：2011-07-08
Applicant: Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanling Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanling Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/427 , A61K31/4245 , A61K31/422 , A61K31/435 , A61K31/40 , A61K31/506 , A61K31/41 , C07D277/20 , C07D271/06 , C07D263/30 , C07D401/02 , C07D239/02 , C07D403/02
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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公开(公告)号：US20140004101A1
公开(公告)日：2014-01-02
申请号：US14013666
申请日：2013-08-29
Applicant: Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: C07D417/04 , A61K31/427 , A61K45/06
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20120207769A1
公开(公告)日：2012-08-16
申请号：US13456274
申请日：2012-04-26
Applicant: Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
Inventor： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC: A61K31/40 , A61K31/663 , A61K31/55 , A61K31/53 , A61K31/519 , A61K31/497 , A61K31/506 , A61K31/437 , A61K31/444 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4025 , A61P35/00 , A61P5/26 , A61K39/395
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
Abstract translation: 抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。
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公开(公告)号：US20110281875A1
公开(公告)日：2011-11-17
申请号：US13178946
申请日：2011-07-08
Applicant: Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
Inventor： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC: A61K31/53 , A61K31/444 , C07D401/04 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/40 , C07D401/14 , A61K31/4439 , C07D413/04 , C07D417/04 , C07D403/04 , C07D207/16 , A61K31/506
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
Abstract translation: 抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。
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公开(公告)号：US20080242658A1
公开(公告)日：2008-10-02
申请号：US10594413
申请日：2005-04-06
Applicant: Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
Inventor： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC: A61K31/407 , C07D471/04 , C07D207/08 , C07D487/04 , C07D207/32 , A61P35/00 , A61K31/4439 , A61K31/422 , A61K31/41 , A61K31/506 , C07D401/04 , C07D403/12 , A61K31/437 , A61K31/55 , A61K31/40
CPC classification number: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
Abstract translation: 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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