公开(公告)号：US20080242658A1

公开(公告)日：2008-10-02

申请号：US10594413

申请日：2005-04-06

申请人： Mark G Palermo ,  Sushil Kumar Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

发明人： Mark G Palermo ,  Sushil Kumar Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

IPC分类号： A61K31/407 ,  C07D471/04 ,  C07D207/08 ,  C07D487/04 ,  C07D207/32 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/41 ,  A61K31/506 ,  C07D401/04 ,  C07D403/12 ,  A61K31/437 ,  A61K31/55 ,  A61K31/40

CPC分类号： C07D207/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

公开(公告)号：US08338440B2

公开(公告)日：2012-12-25

申请号：US13456274

申请日：2012-04-26

申请人： Mark G. Palermo ,  Sushil Kumar Sharma ,  Christopher Sean Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

发明人： Mark G. Palermo ,  Sushil Kumar Sharma ,  Christopher Sean Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

IPC分类号： A61K31/427 ,  A61K31/4245 ,  A61K31/422 ,  A61K31/435 ,  A61K31/40 ,  A61K31/506 ,  A61K31/41

CPC分类号： C07D207/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).

公开(公告)号：US08207183B2

公开(公告)日：2012-06-26

申请号：US13178946

申请日：2011-07-08

申请人： Mark G. Palermo ,  Sushil Kumar Sharma ,  Christopher Sean Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanling Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

发明人： Mark G. Palermo ,  Sushil Kumar Sharma ,  Christopher Sean Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanling Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

IPC分类号： A61K31/427 ,  A61K31/4245 ,  A61K31/422 ,  A61K31/435 ,  A61K31/40 ,  A61K31/506 ,  A61K31/41 ,  C07D277/20 ,  C07D271/06 ,  C07D263/30 ,  C07D401/02 ,  C07D239/02 ,  C07D403/02

CPC分类号： C07D207/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).

公开(公告)号：US07419975B2

公开(公告)日：2008-09-02

申请号：US11099941

申请日：2005-04-06

申请人： Mark Gabriel Palermo ,  Sushil Kumar Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Scott Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

发明人： Mark Gabriel Palermo ,  Sushil Kumar Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Scott Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark G. Charest ,  Feng He

IPC分类号： A61K31/407 ,  A61K31/437 ,  A61K31/55 ,  C07D487/04 ,  C07D471/04

CPC分类号： C07D207/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

公开(公告)号：US20050234042A1

公开(公告)日：2005-10-20

申请号：US11099941

申请日：2005-04-06

申请人： Mark Palermo ,  Sushil Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark Charest ,  Feng He

发明人： Mark Palermo ,  Sushil Sharma ,  Christopher Straub ,  Run-Ming Wang ,  Leigh Zawel ,  Yanlin Zhang ,  Zhuoliang Chen ,  Yaping Wang ,  Fan Yang ,  Wojciech Wrona ,  Gang Liu ,  Mark Charest ,  Feng He

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/55 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D207/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

公开(公告)号：US20180186770A1

公开(公告)日：2018-07-05

申请号：US15736925

申请日：2016-06-15

申请人： Zhuoliang Chen ,  Jorge Garcia Fortanet ,  Andriana Jouk ,  Rajesh Karki ,  Matthew J. LaMarche ,  Gang Liu ,  Mark G. Palermo ,  Lawrence Blas Perez ,  Patrick James Sarver ,  Michael David Shultz ,  Martin Sendzik ,  Bakary-Barry Toure ,  Bing Yu

发明人： Zhuoliang Chen ,  Jorge Garcia Fortanet ,  Andriana Jouk ,  Rajesh Karki ,  Matthew J. LaMarche ,  Gang Liu ,  Mark G. Palermo ,  Lawrence Blas Perez ,  Patrick James Sarver ,  Michael David Shultz ,  Martin Sendzik ,  Bakary-Barry Toure ,  Bing Yu

IPC分类号： C07D401/14 ,  C07D491/107 ,  C07D498/10 ,  C07D471/10 ,  C07D401/04

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D471/10 ,  C07D491/107 ,  C07D498/10

摘要： The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

公开(公告)号：US09434719B2

公开(公告)日：2016-09-06

申请号：US14408418

申请日：2014-03-12

申请人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

IPC分类号： C07D413/04 ,  A61K31/506 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

公开(公告)号：US08957068B2

公开(公告)日：2015-02-17

申请号：US14347481

申请日：2012-09-26

申请人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

IPC分类号： C07D413/04 ,  C07D413/14 ,  A61K31/506 ,  C07D487/04 ,  C07D471/04 ,  C07D487/08 ,  C07D417/14 ,  C07D498/10

CPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D498/10 ,  C07D513/04

摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。 本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。 本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

公开(公告)号：US10914361B2

公开(公告)日：2021-02-09

申请号：US16201979

申请日：2018-11-27

申请人： Gang Liu

发明人： Gang Liu

IPC分类号： F16H1/28 ,  F16H57/04 ,  F16H3/44 ,  F16H57/031 ,  F16H57/038

摘要： Disclosed is a multi-gear torquer with end covers on both sides of the casing. An input shaft and an output shaft are respectively arranged at the center of the two end covers. A sun gear is fixed on the input shaft and moves along a planet gear engaged in the transmission mechanism. The planet gear meshes with a gear ring and moves around the sun gear, then the planet gear drives the turntable centrally fixed with the output shaft connected to the load end. The multi-gear torquer disclosed herein has the following advantages: large output torque and high mechanical efficiency, and it can be used as power transmission equipment for a car or a train and used as other mechanical transmission equipment.

公开(公告)号：US10670143B2

公开(公告)日：2020-06-02

申请号：US15939342

申请日：2018-03-29

申请人： Gang Liu

发明人： Gang Liu

IPC分类号： F16H1/32 ,  F16H61/662 ,  H02K7/116 ,  H02K1/27 ,  F16H61/14 ,  H02K21/16 ,  F16H57/02

摘要： A motor with a variable-speed torque converter is disclosed. A rotor of the motor has a common permanent magnet structure. Permanent magnets are disposed on the rotor. The variable-speed torque converter includes a wheel disc, a wheel ring, a roller, a transmission gear II, a transmission gear III, a round wheel, an annular gear, a driving gear, turning discs, a transmission shaft, and an output shaft. The driving gear fixedly connected to the transmission shaft of the motor drives the transmission gear. The transmission gear is in contact with the annular gear. The transmission gear rotates around the driving gear to drive the wheel disc to rotate together. The wheel disc is fixedly connected to the output shaft to drive a driving wheel to rotate. Therefore, a working capability of the motor is enhanced. The converter can be applied to an electromotor, a generator, or any other power device.