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公开(公告)号：US20110098294A1
公开(公告)日：2011-04-28
申请号：US12302738
申请日：2007-04-23
申请人： Dennis A. Carson , Howard B. Cottam , Guangyi Jin , Christina C.N. Wu , Kenji Takabayashi , Suzanne Grimshaw
发明人： Dennis A. Carson , Howard B. Cottam , Guangyi Jin , Christina C.N. Wu , Kenji Takabayashi , Suzanne Grimshaw
IPC分类号： A61K31/5377 , C07D473/28 , C07K2/00 , C07K14/00 , C07K16/00 , C07H19/16 , A61K31/522 , C07D413/14 , A61P35/00 , A61P31/00 , C12N1/00
CPC分类号： A61K47/48046 , C07D473/18
摘要： The present invention provides a new patentable class of purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals.
摘要翻译： 本发明提供了一种新的可专利类嘌呤类似物类化合物，以及使用它们的组合物和方法，例如预防或治疗人和非人动物中的各种疾病和病症。
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公开(公告)号：US08846697B2
公开(公告)日：2014-09-30
申请号：US12302738
申请日：2007-04-23
IPC分类号： A61K31/52 , C07D473/18
CPC分类号： A61K47/48046 , C07D473/18
摘要： The present invention provides purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals. For example, the invention provides for a compound having formula II:
摘要翻译： 本发明提供嘌呤类似物，以及使用它们的组合物和方法，例如预防或治疗人和非人动物中的各种疾病和病症。 例如，本发明提供了具有式II的化合物：
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公开(公告)号：US20090324551A1
公开(公告)日：2009-12-31
申请号：US12064529
申请日：2006-08-21
申请人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
发明人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
IPC分类号： A61K45/00 , C07D473/00 , A61K31/522 , C12N1/20 , C12N7/00 , A61P35/00
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
摘要翻译： 本发明提供了TLR激动剂缀合物（化合物）和组合物，以及使用它们的方法。 本发明的化合物是合成免疫刺激剂的广谱，持久和无毒组合，其可用于激活哺乳动物，优选人的免疫系统，并且可以帮助将药效团引导至受体内的受体 靶细胞的内体，并增强由药效团诱导的信号转导。
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公开(公告)号：US09359360B2
公开(公告)日：2016-06-07
申请号：US13682208
申请日：2012-11-20
申请人： Suzanne Grimshaw
IPC分类号： A61K31/52 , A61K31/7076 , C12P19/40 , C07D473/16 , C07D473/34 , C07D473/18 , C07D473/24
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
摘要翻译： 本发明提供了TLR激动剂缀合物（化合物）和组合物，以及使用它们的方法。 本发明的化合物是合成免疫刺激剂的广谱，持久和无毒组合，其可用于激活哺乳动物，优选人的免疫系统，并且可以帮助将药效团引导至受体内的受体 靶细胞的内体，并增强由药效团诱导的信号转导。
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公开(公告)号：US20130165455A1
公开(公告)日：2013-06-27
申请号：US13682208
申请日：2012-11-20
IPC分类号： C07D473/34
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
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