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公开(公告)号：US20090324551A1
公开(公告)日：2009-12-31
申请号：US12064529
申请日：2006-08-21
申请人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
发明人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
IPC分类号： A61K45/00 , C07D473/00 , A61K31/522 , C12N1/20 , C12N7/00 , A61P35/00
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
摘要翻译： 本发明提供了TLR激动剂缀合物（化合物）和组合物，以及使用它们的方法。 本发明的化合物是合成免疫刺激剂的广谱，持久和无毒组合，其可用于激活哺乳动物，优选人的免疫系统，并且可以帮助将药效团引导至受体内的受体 靶细胞的内体，并增强由药效团诱导的信号转导。
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公开(公告)号：US20130165455A1
公开(公告)日：2013-06-27
申请号：US13682208
申请日：2012-11-20
IPC分类号： C07D473/34
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
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公开(公告)号：US20130202629A1
公开(公告)日：2013-08-08
申请号：US13695385
申请日：2011-04-29
IPC分类号： A61K39/39 , C07F9/6561
CPC分类号： A61K39/39 , A61K31/52 , A61K31/66 , A61K39/07 , A61K47/544 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , C07F9/65616 , Y02A50/414
摘要： The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection.
摘要翻译： 本发明提供了用于例如疫苗中TLR激动剂的磷脂缀合物的用途，并且用于预防，抑制或治疗各种疾病，包括炎症，癌症和病原体，例如微生物感染。
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公开(公告)号：US08729088B2
公开(公告)日：2014-05-20
申请号：US12704343
申请日：2010-02-11
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D519/00
摘要： Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors. For example, such conjugates include a structure according to Formula I:
摘要翻译： 本文提供作为一种或多种toll样受体的激动剂或拮抗剂的小分子缀合物。 例如，这种缀合物包括根据式I的结构：
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公开(公告)号：US20100210598A1
公开(公告)日：2010-08-19
申请号：US12704343
申请日：2010-02-11
IPC分类号： A61K31/522 , C07D473/04 , C07F9/6558 , A61K31/688 , C07F9/6524 , A61K31/685 , A61K31/52 , A61P29/00 , A61P37/06
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D519/00
摘要： Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.
摘要翻译： 本文提供作为一种或多种toll样受体的激动剂或拮抗剂的小分子缀合物。
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公开(公告)号：US09359360B2
公开(公告)日：2016-06-07
申请号：US13682208
申请日：2012-11-20
申请人： Suzanne Grimshaw
IPC分类号： A61K31/52 , A61K31/7076 , C12P19/40 , C07D473/16 , C07D473/34 , C07D473/18 , C07D473/24
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
摘要翻译： 本发明提供了TLR激动剂缀合物（化合物）和组合物，以及使用它们的方法。 本发明的化合物是合成免疫刺激剂的广谱，持久和无毒组合，其可用于激活哺乳动物，优选人的免疫系统，并且可以帮助将药效团引导至受体内的受体 靶细胞的内体，并增强由药效团诱导的信号转导。
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公开(公告)号：US08965579B2
公开(公告)日：2015-02-24
申请号：US13360590
申请日：2012-01-27
申请人： Yulun Wang , Charles S. Jordan , Tim Wright , Michael Chan , Marco Pinter , Kevin Hanrahan , Daniel Sanchez , James Ballantyne , Cody Herzog , Blair Whitney , Fuji Lai , Kelton Temby , Eben Christopher Rauhut , Justin H. Kearns , Cheuk Wah Wong , Timothy Sturtevant Farlow
发明人： Yulun Wang , Charles S. Jordan , Tim Wright , Michael Chan , Marco Pinter , Kevin Hanrahan , Daniel Sanchez , James Ballantyne , Cody Herzog , Blair Whitney , Fuji Lai , Kelton Temby , Eben Christopher Rauhut , Justin H. Kearns , Cheuk Wah Wong , Timothy Sturtevant Farlow
CPC分类号： B25J9/1664 , B25J5/00 , B25J9/1689 , B25J9/1697 , B25J11/009 , B25J11/0095 , G05D1/0038 , G05D1/024 , G05D1/0274 , G05D2201/0206 , G06F3/0482 , G06F3/04842 , G06F3/04847 , G06F19/00 , G06F19/3418 , G06T11/00 , G06T11/60 , G06T15/10 , G06T2200/24 , Y10S901/01 , Y10S901/47
摘要： A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.
摘要翻译： 远程呈现机器人可以包括驱动系统，控制系统，成像系统和映射模块。 映射模块可以访问与该区域相关联的区域和标签的平面图。 在各种实施例中，每个标签可以包括标签坐标和标签信息，其可以包括标签注释。 标签识别系统可以识别当前位置的预定范围内的标签，并且控制系统可以基于识别的标签来执行动作，其标签信息包括远程呈现机器人动作修改器。 远程呈现机器人可以独立于下部旋转上部部分。 远程终端可以允许操作者使用控制方法的任何组合来控制远程呈现机器人，包括通过在平面视图中选择目的地，或者通过使用操纵杆或其它外围设备来选择实况视频馈送中的目的地。
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8.发明申请Method and Application for Borrowers at Risk for Foreclosure and Participation in Regulated Home Affordability Program 审中-公开借款人的风险抵押和参与受管制的家庭负担能力计划的方法和申请公开(公告)号：US20140222657A1
公开(公告)日：2014-08-07
申请号：US14162582
申请日：2014-01-23
IPC分类号： G06Q40/02
CPC分类号： G06Q40/025
摘要： A method to identify potential borrowers/homeowners/applicants who are at risk of foreclosure and determine whether said borrower/homeowners/applicants are eligible for the National Making Home Affordable Program or other regulated loan modification program.
摘要翻译： 确定潜在的借款人/房主/申请人有可能被取消止赎的方法，并确定所述借款人/房主/申请人是否有资格参加国家家庭负担计划或其他受管制的贷款修改计划。
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公开(公告)号：US08718837B2
公开(公告)日：2014-05-06
申请号：US13360579
申请日：2012-01-27
申请人： Yulun Wang , Charles S. Jordan , Tim Wright , Michael Chan , Marco Pinter , Kevin Hanrahan , Daniel Sanchez , James Ballantyne , Cody Herzog , Blair Whitney , Fuji Lai , Kelton Temby , Eben Christopher Rauhut , Justin H. Kearns , Cheuk Wah Wong , Timothy Sturtevant Farlow
发明人： Yulun Wang , Charles S. Jordan , Tim Wright , Michael Chan , Marco Pinter , Kevin Hanrahan , Daniel Sanchez , James Ballantyne , Cody Herzog , Blair Whitney , Fuji Lai , Kelton Temby , Eben Christopher Rauhut , Justin H. Kearns , Cheuk Wah Wong , Timothy Sturtevant Farlow
IPC分类号： G01C21/00
CPC分类号： B25J9/1664 , B25J5/00 , B25J9/1689 , B25J9/1697 , B25J11/009 , B25J11/0095 , G05D1/0038 , G05D1/024 , G05D1/0274 , G05D2201/0206 , G06F3/0482 , G06F3/04842 , G06F3/04847 , G06F19/00 , G06F19/3418 , G06T11/00 , G06T11/60 , G06T15/10 , G06T2200/24 , Y10S901/01 , Y10S901/47
摘要： A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.
摘要翻译： 远程呈现机器人可以包括驱动系统，控制系统，成像系统和映射模块。 映射模块可以访问与该区域相关联的区域和标签的平面图。 在各种实施例中，每个标签可以包括标签坐标和标签信息，其可以包括标签注释。 标签识别系统可以识别当前位置的预定范围内的标签，并且控制系统可以基于识别的标签来执行动作，其标签信息包括远程呈现机器人动作修改器。 远程呈现机器人可以独立于下部旋转上部部分。 远程终端可以允许操作者使用控制方法的任何组合来控制远程呈现机器人，包括通过在平面视图中选择目的地，或者通过使用操纵杆或其它外围设备来选择实况视频馈送中的目的地。
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公开(公告)号：US08148230B2
公开(公告)日：2012-04-03
申请号：US12656306
申请日：2010-01-25
申请人： Vance Dunton , Raghuveer S. Makala , Michael Chan
发明人： Vance Dunton , Raghuveer S. Makala , Michael Chan
IPC分类号： H01L21/20
CPC分类号： H01L27/101 , H01L21/32134 , H01L27/1021 , H01L27/2409 , H01L45/04 , H01L45/06 , H01L45/085 , H01L45/1233 , H01L45/141 , H01L45/146 , H01L45/147 , H01L45/149 , H01L45/16
摘要： A method of making a semiconductor device includes providing an insulating layer containing a plurality of openings, forming a first conductivity type semiconductor layer in the plurality of openings, forming a second conductivity type semiconductor layer over the first conductivity type semiconductor layer in the plurality of openings, and selectively etching the second conductivity type semiconductor layer using an upper surface of the first conductivity type semiconductor layer as a stop to form a recess in the plurality of openings.
摘要翻译： 制造半导体器件的方法包括提供包含多个开口的绝缘层，在多个开口中形成第一导电类型半导体层，在多个开口中的第一导电类型半导体层上形成第二导电类型半导体层 并且使用第一导电类型半导体层的上表面作为停止来选择性地蚀刻第二导电类型半导体层，以在多个开口中形成凹部。
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