公开(公告)号：US20090071848A1

公开(公告)日：2009-03-19

申请号：US11915697

申请日：2006-05-26

申请人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

发明人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

IPC分类号： G01N27/26

CPC分类号： G01N27/403 ,  C12Q1/004 ,  C12Q1/005 ,  G01N33/54346 ,  G01N33/54373

摘要： An electrochemical sensor system for sensing free radicals or materials which generate free radicals in solution includes a working electrode coated with a plurality of cerium oxide nanoparticles and a counter electrode. A solution to be analyzed provides electrolytes to electrically couple the working electrode to the counter electrode. Electronics are connected to at least one of the working and counter electrodes for measuring and amplifying an electrical current signal generated by reduction or oxidation occurring at the working electrode, wherein in a presence of free radicals an electrical current signal flows between the working electrode and the counter electrode. The system can be used to sense the presence of hydrogen peroxide.

摘要翻译： 用于感测在溶液中产生自由基的自由基或材料的电化学传感器系统包括涂覆有多个氧化铈纳米颗粒的工作电极和对电极。 待分析的解决方案提供电解质以将工作电极电耦合到对电极。 电子器件连接到工作电极和对电极中的至少一个，用于测量和放大在工作电极处发生的还原或氧化产生的电流信号，其中在存在自由基的情况下，电流信号在工作电极和 对电极。 该系统可用于感测过氧化氢的存在。

公开(公告)号：US08172997B2

公开(公告)日：2012-05-08

申请号：US11915697

申请日：2006-05-26

申请人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

发明人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

IPC分类号： G01N27/327

CPC分类号： G01N27/403 ,  C12Q1/004 ,  C12Q1/005 ,  G01N33/54346 ,  G01N33/54373

摘要： An electrochemical sensor system for sensing free radicals or materials which generate free radicals in solution includes a working electrode coated with a plurality of cerium oxide nanoparticles and a counter electrode. A solution to be analyzed provides electrolytes to electrically couple the working electrode to the counter electrode. Electronics are connected to at least one of the working and counter electrodes for measuring and amplifying an electrical current signal generated by reduction or oxidation occurring at the working electrode, wherein in a presence of free radicals an electrical current signal flows between the working electrode and the counter electrode. The system can be used to sense the presence of hydrogen peroxide.

摘要翻译： 用于感测在溶液中产生自由基的自由基或材料的电化学传感器系统包括涂覆有多个氧化铈纳米颗粒的工作电极和对电极。 待分析的解决方案提供电解质以将工作电极电耦合到对电极。 电子器件连接到工作电极和对电极中的至少一个，用于测量和放大在工作电极处发生的还原或氧化产生的电流信号，其中在存在自由基的情况下，电流信号在工作电极和 对电极。 该系统可用于感测过氧化氢的存在。

公开(公告)号：US07959690B1

公开(公告)日：2011-06-14

申请号：US11788723

申请日：2007-04-20

申请人： Sudipta Seal ,  Eric L. Petersen ,  Sameer Deshpande ,  Swanand Patil ,  Suresh Chandra Kuiry

发明人： Sudipta Seal ,  Eric L. Petersen ,  Sameer Deshpande ,  Swanand Patil ,  Suresh Chandra Kuiry

IPC分类号： C10L1/12

CPC分类号： C10L9/10 ,  B82Y30/00 ,  C10L1/1233 ,  C10L1/2437 ,  C10L10/02 ,  C10L10/04 ,  F23K5/08

摘要： Novel nano-sized rare earth metal oxide prepared from aqueous reverse micelles is provided. The engineered nanoparticles have large surface area to volume ratios, and sufficient oxygen vacancies on the surface of each particle, so that when mixed with carbon-containing combustible fuels, the particles remain suspended indefinitely; there is a significant reduction in soot and other by-products of combustion, an increase in engine efficiency and less fuel consumed per mile traveled in various vehicles, such as, but not limited to, automobiles, defense vehicles, airplanes, ships and other surface or air-bearing vehicles.

摘要翻译： 提供从水性反胶束制备的新型纳米级稀土金属氧化物。 工程纳米颗粒具有大的表面积与体积比，并且在每个颗粒的表面上具有足够的氧空位，使得当与含碳可燃燃料混合时，颗粒保持无限期地悬浮; 燃烧烟灰和其他副产物的显着减少，发动机效率的提高和各种车辆（例如但不限于汽车，国防车辆，飞机，船舶和其他表面）行驶的每英里消耗的燃料消耗减少 或空运车辆。

公开(公告)号：US07534453B1

公开(公告)日：2009-05-19

申请号：US10655143

申请日：2003-09-04

申请人： Beverly A. Rzigalinski ,  Sudipta Seal ,  David Bailey ,  Swanand Patil

发明人： Beverly A. Rzigalinski ,  Sudipta Seal ,  David Bailey ,  Swanand Patil

IPC分类号： A01N59/16 ,  A61K33/24

CPC分类号： A61K33/24 ,  A01N1/02 ,  A01N1/0226

摘要： Novel, nonagglomerated, engineered, ultra fine Cerium Oxide particles the size of approximately 2 to approximately 10 nm and methods for preparation of the particles. The resultant particles enhance the longevity of cells in culture. Applications of the particles include benefits for wound healing, treating arthritis and joint diseases, anti-aging and the treating of inflammations.

摘要翻译： 新型的，非团聚的，工程化的超细氧化铈颗粒，其尺寸约为2至约10nm，以及制备颗粒的方法。 所得颗粒增强培养细胞的寿命。 颗粒的应用包括伤口愈合，治疗关节炎和关节疾病，抗衰老和炎症治疗的益处。

公开(公告)号：US07347987B2

公开(公告)日：2008-03-25

申请号：US11796347

申请日：2007-04-27

申请人： James F. McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

发明人： James F. McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

IPC分类号： A61K8/00

CPC分类号： A61K33/24

摘要： Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

摘要翻译： 提供了可用于体外视网膜细胞中神经元保护的方法和组合，并且在体内保护哺乳动物细胞免受活性氧的影响。 已经提供了直径小于10纳米的超细纳米尺寸氧化铈颗粒，以减少产生大量ROS的视网膜组织中的活性氧（ROS）。 这些活性氧（ROS）参与光诱导的视网膜变性和年龄相关性黄斑变性（AMD）。 已经使用氧化铈纳米粒子来促进视网膜神经元的寿命，并保护神经元免受体外和体内过氧化氢诱导的细胞凋亡。 通过减少细胞内活性氧（ROS）的产生来实现视网膜细胞中的神经元保护。 因此，氧化铈颗粒用于体外促进视网膜神经元在体外和哺乳动物细胞的寿命。

公开(公告)号：US07727559B2

公开(公告)日：2010-06-01

申请号：US11412665

申请日：2006-04-27

申请人： James F. McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

发明人： James F. McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

IPC分类号： A61K33/24 ,  A01N59/16

CPC分类号： A61K33/24

摘要： Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

摘要翻译： 提供了可用于体外视网膜细胞中神经元保护的方法和组合，并且在体内保护哺乳动物细胞免受活性氧的影响。 已经提供了直径小于10纳米的超细纳米尺寸氧化铈颗粒，以减少产生大量ROS的视网膜组织中的活性氧（ROS）。 这些活性氧（ROS）参与光诱导的视网膜变性和年龄相关性黄斑变性（AMD）。 已经使用氧化铈纳米粒子来促进视网膜神经元的寿命，并保护神经元免受体外和体内过氧化氢诱导的细胞凋亡。 通过减少细胞内活性氧（ROS）的产生来实现视网膜细胞中的神经元保护。 因此，氧化铈颗粒用于体外促进视网膜神经元在体外和哺乳动物细胞的寿命。

公开(公告)号：US07419516B1

公开(公告)日：2008-09-02

申请号：US10846023

申请日：2004-05-14

申请人： Sudipta Seal ,  Eric L. Petersen ,  Sameer Deshpande ,  Swanand Patil ,  Suresh Chandra Kuiry

发明人： Sudipta Seal ,  Eric L. Petersen ,  Sameer Deshpande ,  Swanand Patil ,  Suresh Chandra Kuiry

IPC分类号： C10L1/12 ,  C10L1/32 ,  C10L5/00

CPC分类号： C10L9/10 ,  B82Y30/00 ,  C10L1/1233 ,  C10L1/2437 ,  C10L10/02 ,  C10L10/04 ,  F23K5/08

摘要： Novel nano-sized rare earth metal oxide prepared from aqueous reverse micelles is provided. The engineered nanoparticles have large surface area to volume ratios, and sufficient oxygen vacancies on the surface of each particle, so that when mixed with carbon-containing combustible fuels, the particles remain suspended indefinitely; there is a significant reduction in soot and other by-products of combustion, an increase in engine efficiency and less fuel consumed per mile traveled in various vehicles, such as, but not limited to, automobiles, defense vehicles, airplanes, ships and other surface or air-bearing vehicles.

摘要翻译： 提供从水性反胶束制备的新型纳米级稀土金属氧化物。 工程纳米颗粒具有大的表面积与体积比，并且在每个颗粒的表面上具有足够的氧空位，使得当与含碳可燃燃料混合时，颗粒保持无限期地悬浮; 燃烧烟灰和其他副产物的显着减少，发动机效率的提高和各种车辆（例如但不限于汽车，国防车辆，飞机，船舶和其他表面）行驶的每英里消耗的燃料消耗减少 或空运车辆。

公开(公告)号：US20070202193A1

公开(公告)日：2007-08-30

申请号：US11796347

申请日：2007-04-27

申请人： James McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

发明人： James McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

IPC分类号： A61K33/24

CPC分类号： A61K33/24

摘要： Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

摘要翻译： 提供了可用于体外视网膜细胞中神经元保护的方法和组合，并且在体内保护哺乳动物细胞免受活性氧的影响。 已经提供了直径小于10纳米的超细纳米尺寸氧化铈颗粒，以减少产生大量ROS的视网膜组织中的活性氧（ROS）。 这些活性氧（ROS）参与光诱导的视网膜变性和年龄相关性黄斑变性（AMD）。 已经使用氧化铈纳米粒子来促进视网膜神经元的寿命，并保护神经元免受体外和体内过氧化氢诱导的细胞凋亡。 通过减少细胞内活性氧（ROS）的产生来实现视网膜细胞中的神经元保护。 因此，氧化铈颗粒用于体外促进视网膜神经元在体外和哺乳动物细胞的寿命。

公开(公告)号：US20060246152A1

公开(公告)日：2006-11-02

申请号：US11412665

申请日：2006-04-27

申请人： James McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

发明人： James McGinnis ,  Junping Chen ,  Lily Wong ,  Steve Sezate ,  Sudipta Seal ,  Swanand Patil

IPC分类号： A61K33/24

CPC分类号： A61K33/24

摘要： Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

摘要翻译： 提供了可用于体外视网膜细胞中神经元保护的方法和组合，并且在体内保护哺乳动物细胞免受活性氧的影响。 已经提供了直径小于10纳米的超细纳米尺寸氧化铈颗粒，以减少产生大量ROS的视网膜组织中的活性氧（ROS）。 这些活性氧（ROS）参与光诱导的视网膜变性和年龄相关性黄斑变性（AMD）。 已经使用氧化铈纳米粒子来促进视网膜神经元的寿命，并保护神经元免受体外和体内过氧化氢诱导的细胞凋亡。 通过减少细胞内活性氧（ROS）的产生来实现视网膜细胞中的神经元保护。 因此，氧化铈颗粒用于体外促进视网膜神经元在体外和哺乳动物细胞的寿命。