公开(公告)号：US20220000991A1

公开(公告)日：2022-01-06

申请号：US17406266

申请日：2021-08-19

申请人： Synthetic Biologics, Inc.

发明人： Michael KALEKO ,  Sheila CONNELLY

IPC分类号： A61K38/50 ,  A61K38/14 ,  A61K31/00 ,  A61K35/741 ,  A61K31/427 ,  A61K31/43 ,  A61K9/00 ,  C12N9/86

摘要： This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.

公开(公告)号：US11034966B2

公开(公告)日：2021-06-15

申请号：US15506342

申请日：2015-08-27

申请人： Synthetic Biologics, Inc.

发明人： Andrew Bristol ,  Michael Kaleko ,  Steven Hubert

IPC分类号： C12N15/70 ,  C12P21/02 ,  C12N9/86 ,  C12N15/67 ,  C12N15/09 ,  C12N15/75

摘要： The invention relates to, in part, improved methods for the production of beta-lactamase using Escherichia coli (E. coli) cells. High yield production of beta-lactamase is achieved using methods of the invention.

公开(公告)号：US10668159B2

公开(公告)日：2020-06-02

申请号：US16405667

申请日：2019-05-07

申请人： Cedars-Sinai Medical Center ,  Synthetic Biologics, Inc.

发明人： Mark Pimentel ,  Ruchi Mathur ,  Steve Kanzer ,  Vince Wacher

IPC分类号： A61K47/38 ,  A61K31/351 ,  A61K47/12 ,  A61K9/28 ,  A61K9/48 ,  A61K9/20 ,  A61K47/18 ,  A61K31/00

摘要： The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.

公开(公告)号：US20200017844A1

公开(公告)日：2020-01-16

申请号：US16414411

申请日：2019-05-16

申请人： Synthetic Biologics, Inc.

发明人： Michael KALEKO ,  Sheila Connelly

IPC分类号： C12N9/86 ,  A61K38/50 ,  A61K9/00 ,  A61K31/546 ,  A61K45/06

摘要： This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract) disorders such as C. difficile infection (CDI).

公开(公告)号：US10253306B2

公开(公告)日：2019-04-09

申请号：US15661416

申请日：2017-07-27

申请人： Synthetic Biologics, Inc.

发明人： Pertti Koski ,  Ulla Airaksinen ,  Katja Valimaki

IPC分类号： C12N9/86 ,  A61K38/50 ,  A61K31/43 ,  A61K31/545 ,  A61K45/06 ,  A61K9/00 ,  A61K9/48 ,  A61K38/00

摘要： The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and pharmaceutical compositions comprising the beta-lactamases. Also, the present invention relates to methods for modifying a beta-lactamase, producing the beta-lactamase and treating or preventing beta-lactam antibiotic induced adverse effects. Furthermore, the present invention relates to the beta-lactamase for use as a medicament and to the use of the beta-lactamase in the manufacture of a medicament for treating or preventing beta-lactam antibiotics induced adverse effects.Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.

公开(公告)号：US20180362621A1

公开(公告)日：2018-12-20

申请号：US16016890

申请日：2018-06-25

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SYNTHETIC BIOLOGICS, INC.

发明人： Jennifer Maynard ,  Annalee Nguyen ,  Eduardo Padlan ,  Ellen Wagner

IPC分类号： C07K16/12 ,  A61K39/40 ,  A61K39/00

摘要： The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.

公开(公告)号：US20180311324A1

公开(公告)日：2018-11-01

申请号：US16031266

申请日：2018-07-10

申请人： Synthetic Biologics, Inc.

发明人： Michael Kaleko ,  Sheila Connelly ,  Vincent John Wacher

IPC分类号： A61K38/50 ,  A61K9/16

摘要： This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.

公开(公告)号：US10035846B2

公开(公告)日：2018-07-31

申请号：US15356217

申请日：2016-11-18

申请人： Board of Regents, The University of Texas System ,  Synthetic Biologics, Inc.

发明人： Jennifer Maynard ,  Annalee Nguyen ,  Eduardo Padlan ,  Ellen Wagner

IPC分类号： C07K16/12 ,  A61K39/40 ,  A61K39/00

CPC分类号： C07K16/1225 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/507 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.

公开(公告)号：US09695409B2

公开(公告)日：2017-07-04

申请号：US15245517

申请日：2016-08-24

申请人： Synthetic Biologics, Inc.

发明人： Michael Kaleko ,  Sheila Connelly

IPC分类号： C12N9/86 ,  A61K45/06 ,  A61K9/00 ,  A61K31/54 ,  A61K31/546 ,  A61K38/50 ,  A61K38/00

CPC分类号： C12N9/86 ,  A61K9/0053 ,  A61K31/546 ,  A61K38/00 ,  A61K38/50 ,  A61K45/06 ,  C12Y305/02006 ,  A61K2300/00

摘要： This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract) disorders such as C. difficile infection (CDI).

公开(公告)号：US20170066816A1

公开(公告)日：2017-03-09

申请号：US15356217

申请日：2016-11-18

申请人： Board of Regents, The University of Texas System ,  Synthetic Biologics, Inc.

发明人： Jennifer Maynard ,  Annalee Nguyen ,  Eduardo Padlan ,  Ellen Wagner

IPC分类号： C07K16/12

CPC分类号： C07K16/1225 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/507 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein.

摘要翻译： 本发明涉及结合百日咳毒素蛋白质的人源化抗体及其作为治疗剂的用途。 特别地，本发明涉及结合百日咳毒素蛋白质的改进的人源化1B7和11E6抗体。