公开(公告)号：US20230125432A1

公开(公告)日：2023-04-27

申请号：US17974331

申请日：2022-10-26

Applicant: TAE Life Sciences, LLC

Inventor： Charles Lee ,  Jedediah Styron

IPC: H05H3/06 ,  A61K41/00 ,  H05H6/00 ,  A61N5/10

Abstract: Systems, devices, and methods for converting a raw neutron beam to a specified deliverable format having a targeted energy range, size, and direction are described. Embodiments of a neutron beam converter can include numerous regions based on location, function, dimension, and/or constituent material. The regions can include a central region, an intermediate region, a peripheral region, and a frontal region. Materials are also described.

公开(公告)号：US20250034176A1

公开(公告)日：2025-01-30

申请号：US18892994

申请日：2024-09-23

Applicant: TAE Life Sciences LLC

Inventor： Michael Y. Torgov ,  Tioga J. Martin ,  Arthur B. Raitano

IPC: C07F5/05 ,  A61K41/00

Abstract: Borylated Amino Acid (“BAA”) compositions and methods of making BAAs are disclosed herein. Consequently, the BAAs can be administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

公开(公告)号：US20250059215A1

公开(公告)日：2025-02-20

申请号：US18796638

申请日：2024-08-07

Applicant: TAE Life Sciences LLC

Inventor： Jason C. Quintana ,  Tioga Martin

IPC: C07F5/02 ,  A61K41/00 ,  A61P35/00

Abstract: Trifluoroborate (BF3) Compounds (“BF3 compounds”) and methods of making BF3 compounds are disclosed herein. Consequently, the BF3 compounds can be administered to patients as a Neutron Capture Agent or as a single agent or in combination with other BF3 compounds and provide a method of treating cancer, immunological disorders, and other disease by utilizing various treatment modalities.

公开(公告)号：US20240066323A1

公开(公告)日：2024-02-29

申请号：US18239568

申请日：2023-08-29

Applicant: TAE Life Sciences, LLC

Inventor： Jedediah Styron ,  Jonathan David McCoy ,  Charles Leon Lee ,  Matthew Alan Core

IPC: A61N5/10 ,  G01T7/00

CPC classification number: A61N5/1071 ,  A61N5/1067 ,  G01T7/005 ,  G01T3/00

Abstract: A method for monitoring and controlling neutron beams includes performing a calibration process for a monitoring dosimeter at a first set of conditions for directing a neutron beam towards an object location, the neutron beam being emitted from a neutron-generating target in response to an incident charged particle beam, the process comprising: obtaining data indicating a first neutron flux measured by the monitoring dosimeter between the monitoring dosimeter and the object location, the monitoring dosimeter offset from the axis by a distance equal to or greater than the beam radius; obtaining data indicating a second neutron flux measured by a reference dosimeter between the target and the object location; storing calibration data including a correlation between the first neutron flux and the second neutron flux; and based on the calibration data, using the monitoring dosimeter to monitor neutron flux incident on a patient during boron neutron capture therapy treatment.

公开(公告)号：US20240120126A1

公开(公告)日：2024-04-11

申请号：US18479714

申请日：2023-10-02

Applicant: TAE Life Sciences, LLC

Inventor： Charles Leon Lee ,  Jedediah Styron ,  Matthew Alan Core ,  Mark Joseph Rouillard ,  Vijay Patel

IPC: G21K1/02 ,  G21K1/04 ,  H05H3/06

CPC classification number: G21K1/025 ,  G21K1/046 ,  H05H3/06

Abstract: Systems, devices, and methods for collimating a neutron beam to specified deliverable formats having targeted beam diameters and direction are described. Examples of a neutron collimator assembly can include numerous components based on location, function, dimension, and/or constituent material. The components can include, neutron beam collimators, a beam stop, a mounting assembly, electro-mechanical actuators, an electronic controller, a safety interlock system, a moveable radiation shield, a safety cover, and an adjustable patient platform. In addition, examples of variable aperture neutron beam collimators such as nested neutron beam collimators and collimators with a diaphragm iris are described. Materials are also described.