-
公开(公告)号：US20240228437A1
公开(公告)日：2024-07-11
申请号：US18557255
申请日：2022-04-25
发明人： Masatoshi YAMADA , Sayuri HIRANO , Osamu YABE , Yuichi KAJITA , Tsuneo ODA , Takashi ABE , Hironori YAMASHITA
IPC分类号： C07D207/14
CPC分类号： C07D207/14
摘要： The present invention provides a method suitable for industrial production of a compound of formula (V): (V) comprising a step of subjecting a compound (IV) to an asymmetric reductive amination reaction in the presence of a metal complex comprising a chiral ligand and subjecting this product to purification using salt formation with N-(4-methylbenzene-1-sulfonyl)-L-phenylalanine.
-
2.发明申请公开(公告)号：US20220144949A1
公开(公告)日：2022-05-12
申请号：US17435931
申请日：2020-03-05
发明人： Robert B. DUBRIDGE , Anand PANCHAL
摘要： Provided herein are compositions of conditionally activated binding proteins containing Fc regions such that the proteins target tumor antigens. Also provided are methods for coexpressing and purifying such conditionally activated binding proteins. Methods of treating cancer by administering the conditionally activated binding proteins to a patient are also described.
-
公开(公告)号：US20240165092A1
公开(公告)日：2024-05-23
申请号：US18553348
申请日：2022-04-01
发明人： Haruhide KIMURA , Motohisa SUZUKI , James CRONICAN
IPC分类号： A61K31/445 , A61P11/00 , A61P39/00
CPC分类号： A61K31/445 , A61P11/00 , A61P39/00
摘要： A method for recovering post operation in a subject in need thereof is disclosed, comprising administering to the subject an effective amount of methyl 3-((methylsulfonyl)amino)-2-(((4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate (Compound (I)), or a salt thereof.
-
-
搜索结果
3 条记录 (耗时 0.017 秒)
