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11 条记录 (耗时 0.048 秒)

    Method of treating acne
    1.
    发明授权
    Method of treating acne 有权
    治疗痤疮的方法

    公开(公告)号：US09011885B2

    公开(公告)日：2015-04-21

    申请号：US14447434

    申请日：2014-07-30

    申请人： Thesan Pharmaceuticals, Inc.

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K9/00 ,  A61K31/00 ,  A61K31/407 ,  A61K31/352

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/407

    摘要： The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type.The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.

    摘要翻译： 使用能够与AhR受体（芳烃受体）瞬时相互作用的化合物作为皮肤病学或化妆品药物，用作调节皮肤功能如皮脂腺功能，皮肤愈合，称为“皮肤病”的皮肤萎缩，雌激素剥夺和防御 免受感染，不引起TCDD类型的其他毒性作用。 选择与AhR受体相互作用的化合物，因为它们具有有利于这些作用的解离的代谢，特别是通过原位原位产生和/或原位调节的代谢。

    Method of Treating Acne
    2.
    发明申请
    Method of Treating Acne 审中-公开
    治疗痤疮的方法

    公开(公告)号：US20150005373A1

    公开(公告)日：2015-01-01

    申请号：US14447434

    申请日：2014-07-30

    申请人： THESAN PHARMACEUTICALS, INC.

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K9/00 ,  A61K31/352

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/407

    摘要： The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type.The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.

    摘要翻译： 使用能够与AhR受体（芳烃受体）瞬时相互作用的化合物作为皮肤病学或化妆品药物，用作调节皮肤功能如皮脂腺功能，皮肤愈合，称为“皮肤病”的皮肤萎缩，雌激素剥夺和防御 免受感染，不引起TCDD类型的其他毒性作用。 选择与AhR受体相互作用的化合物，因为它们具有有利于这些作用的解离的代谢，特别是通过原位原位产生和/或原位调节的代谢。

    Method of treating acne
    5.
    发明授权
    Method of treating acne 有权

    公开(公告)号：US09358220B2

    公开(公告)日：2016-06-07

    申请号：US14607597

    申请日：2015-01-28

    申请人： THESAN PHARMACEUTICALS, INC.

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K9/00 ,  A61K31/352 ,  A61K31/00 ,  A61K31/407

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/407

    摘要： The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type.The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.

    Method of Treating Acne
    7.
    发明申请
    Method of Treating Acne 审中-公开

    公开(公告)号：US20150216840A1

    公开(公告)日：2015-08-06

    申请号：US14607597

    申请日：2015-01-28

    申请人： THESAN PHARMACEUTICALS, INC.

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K31/352 ,  A61K9/00

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/407

    摘要： The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type.The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.

    Therapeutic pyrazolyl thienopyridines
    10.
    发明授权
    Therapeutic pyrazolyl thienopyridines 有权
    治疗性吡唑并噻吩并吡啶类

    公开(公告)号：US09090625B2

    公开(公告)日：2015-07-28

    申请号：US13864457

    申请日：2013-04-17

    申请人： Thesan Pharmaceuticals, Inc.

    发明人： Stephen D. Barrett ,  James B. Kramer ,  Mark L. Boys ,  Huifen Chen

    IPC分类号： A61K31/4365 ,  C07D495/04

    CPC分类号： C07D495/04 ,  A61K9/0014 ,  A61K31/4365

    摘要： The present invention provides for compounds of Formula I, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as therapeutic agents in the treatment of TGFβ-mediated conditions, including cancer and fibrotic disorders. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

    摘要翻译： 本发明提供式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7具有本说明书中定义的任何值及其药学上可接受的盐， 可用作治疗TGF-bgr介导的病症，包括癌症和纤维化疾病的治疗剂。 还提供了包含一种或多种式I化合物的药物组合物。