公开(公告)号：US20110098358A1

公开(公告)日：2011-04-28

申请号：US12997498

申请日：2009-06-11

申请人： Yasuo Fujimoto ,  Shoichi Kurihara ,  Tadao Hamaya

发明人： Yasuo Fujimoto ,  Shoichi Kurihara ,  Tadao Hamaya

IPC分类号： A61K31/202

CPC分类号： A61K45/06 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K2300/00

摘要： A human adrenergic β3 receptor ligand containing the following 3 components: (A) an unsaturated fatty acid having not less than three double bonds or a pharmaceutically acceptable salt thereof, (B) an unsaturated fatty acid having one or two double bond(s) or a pharmaceutically acceptable salt thereof; and (C) a saturated fatty acid or a pharmaceutically acceptable salt thereof; and a food product and a pharmaceutical containing it, especially, an agent for prophylaxis and/or amelioration of lifestyle-related diseases such as obesity, adipositas, diabetes, hyperlipemia, hypertension and/or gout.

摘要翻译： 含有以下3种成分的人肾上腺素能受体配体：（A）不少于三个双键的不饱和脂肪酸或其药学上可接受的盐，（B）具有一个或两个双键的不饱和脂肪酸 ）或其药学上可接受的盐; 和（C）饱和脂肪酸或其药学上可接受的盐; 以及含有它的食品和药物，特别是用于预防和/或改善诸如肥胖，脂肪，糖尿病，高脂血症，高血压和/或痛风的生活方式相关疾病的药剂。

公开(公告)号：US07195675B2

公开(公告)日：2007-03-27

申请号：US11100379

申请日：2005-04-07

申请人： Hideo Okazaki ,  Tadao Hamaya ,  Shoichi Kurihara

发明人： Hideo Okazaki ,  Tadao Hamaya ,  Shoichi Kurihara

IPC分类号： C07H3/02

CPC分类号： C08B37/003 ,  A61K31/722 ,  A61K36/07

摘要： The present invention herein provides a chitosan-containing polysaccharide and a method for the preparation thereof as well as a medicine and a food containing the polysaccharide.The chitosan-containing polysaccharide is prepared by a method comprising the steps of heat-treating a fungus in a concentrated aqueous caustic alkali solution; subjecting the resulting solution to a solid-liquid separation treatment; dissolving the resulting solid contents in an aqueous organic acid solution; adding, to the resulting solution, an alcohol or a caustic alkali to thus form precipitates; washing the resulting precipitates; and then drying them. This chitosan-containing polysaccharide is a compound in which homopolymers of glucosamine are linked with glucan through covalent bonds; it has a molar ratio of glucosamine and glucose constituting the polysaccharide ranging from 1:5 to 5:1; it has a molecular weight of about 150,000; and it does not contain any β(1→3) bonds, but comprises β(1→4) bonds and β(1→6) bonds. The polysaccharide is free of any protein and reducing polysaccharide. The chitosan-containing polysaccharide is effective for the treatment or prevention of any diseases originated from living habits or customs such as hypertension and diabetes.

摘要翻译： 本发明提供含壳聚糖的多糖及其制备方法以及含有多糖的药物和食品。

公开(公告)号：US20050236328A1

公开(公告)日：2005-10-27

申请号：US11100379

申请日：2005-04-07

申请人： Hideo Okazaki ,  Tadao Hamaya ,  Shoichi Kurihara

发明人： Hideo Okazaki ,  Tadao Hamaya ,  Shoichi Kurihara

IPC分类号： A61K31/722 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P43/00 ,  C08B37/08 ,  B01D11/00 ,  A61K31/715

CPC分类号： C08B37/003 ,  A61K31/722 ,  A61K36/07

摘要： The present invention herein provides a chitosan-containing polysaccharide and a method for the preparation thereof as well as a medicine and a food containing the polysaccharide. The chitosan-containing polysaccharide is prepared by a method comprising the steps of heat-treating a fungus in a concentrated aqueous caustic alkali solution; subjecting the resulting solution to a solid-liquid separation treatment; dissolving the resulting solid contents in an aqueous organic acid solution; adding, to the resulting solution, an alcohol or a caustic alkali to thus form precipitates; washing the resulting precipitates; and then drying them. This chitosan-containing polysaccharide is a compound in which homopolymers of glucosanine are linked with glucan through covalent bonds; it has a molar ratio of glucosamine and glucose constituting the polysaccharide ranging from 1:5 to 5:1; it has a molecular weight of about 150,000; and it does not contain any β(1→3) bonds, but comprises β(1→4) bonds and β(1→6) bonds. The polysaccharide is free of any protein and reducing polysaccharide. The chitosan-containing polysaccharide is effective for the treatment or prevention of any diseases originated from living habits or customs such as hypertension and diabetes.

摘要翻译： 本发明提供含壳聚糖的多糖及其制备方法以及含有多糖的药物和食品。 含壳聚糖的多糖通过包括以下步骤的方法制备：将浓缩的苛性碱水溶液中的真菌进行热处理; 对所得溶液进行固液分离处理; 将所得固体内容物溶解在有机酸水溶液中; 向所得溶液中加入醇或苛性碱，从而形成沉淀物; 洗涤所得沉淀物; 然后干燥。 该含壳聚糖的多糖是其中葡糖苷的均聚物通过共价键与葡聚糖连接的化合物; 构成多糖的葡糖胺和葡萄糖的摩尔比为1:5至5:1; 它的分子量约为15万; 并且它不包含任何β（1-> 3）键，但包含β（1-> 4）键和β（1-> 6）键。 多糖不含任何蛋白质和还原多糖。 含壳聚糖的多糖对于治疗或预防任何起源于高血压和糖尿病等生活习惯或风俗的疾病是有效的。

公开(公告)号：US5639470A

公开(公告)日：1997-06-17

申请号：US107333

申请日：1993-08-16

申请人： Sadami Ishibashi ,  Tadao Hamaya ,  Tadashi Imai ,  Masao Iijima

发明人： Sadami Ishibashi ,  Tadao Hamaya ,  Tadashi Imai ,  Masao Iijima

IPC分类号： A61L9/01 ,  A23L1/28 ,  A61K8/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/67 ,  A61K8/97 ,  A61Q11/00 ,  A61Q15/00 ,  A61K7/26

CPC分类号： A61L9/01 ,  A23L31/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/676 ,  A61K8/975 ,  A61Q11/00 ,  A61Q15/00 ,  Y10S514/901

摘要： A deodorizer comprises a hydrophilic solvent extract of fruit-bodies of champignon mushroom or powder of the extract as an effective component. The extract of champignon mushroom used as an effective component can be prepared by a method which comprises the step of immersing the mushroom in a hydrophilic solvent at a temperature ranging from 60.degree. to 100.degree. C. for 15 minutes to 2 hours to perform extraction. The extract can further be treated to obtain the effective components in the form of powder. The extract and the powder thereof can be used as an effective component of a deodorizer capable of oral intake, which serves as a deodorizer for preventing bad smell of environment or an agent for preventing foul breath, which can also be used in foods for eating or drinking to prevent giving out of bad smell emitted from cookings such as those containing garlic and leek as well as cooked fish, which can prevents giving out of bad smell after taking such cookings, and which can be involved in metabolism to thus suppress the giving out of bad smell from urine and feces discharged after eating and drinking such foods.

摘要翻译： 除臭剂包括香菇的果实的亲水性溶剂提取物或提取物的粉末作为有效成分。 用作有效成分的香菇菇的提取物可以通过包括以下步骤的方法制备：将蘑菇浸入亲水性溶剂中，温度在60℃至100℃下15分钟至2小时进行萃取。 可以进一步处理提取物以获得粉末形式的有效成分。 提取物及其粉末可以用作能够口服的除臭剂的有效成分，其作为用于防止恶臭气味的除臭剂或用于防止臭味的药剂，其也可用于食用食品或 饮用以防止排出的诸如含有大蒜和韭菜的烹饪物质以及煮熟的鱼类产生的不良气味，其可以防止在进行这种烹饪之后发出不良气味，并且可以参与新陈代谢从而抑制发出 食用和饮用这些食物后尿液和粪便排出的气味很差。

公开(公告)号：US5804174A

公开(公告)日：1998-09-08

申请号：US777603

申请日：1996-12-31

申请人： Sadami Ishibashi ,  Tadao Hamaya ,  Tadashi Imai ,  Masao Iijima

发明人： Sadami Ishibashi ,  Tadao Hamaya ,  Tadashi Imai ,  Masao Iijima

IPC分类号： A61L9/01 ,  A23L1/28 ,  A61K8/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/67 ,  A61K8/97 ,  A61Q11/00 ,  A61Q15/00

CPC分类号： A61L9/01 ,  A23L31/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/676 ,  A61K8/975 ,  A61Q11/00 ,  A61Q15/00 ,  Y10S514/901

摘要： A deodorizer comprises a hydrophilic solvent extract of fruit-bodies of champignon mushroom or powder of the extract as an effective component. The extract of champignon mushroom used as an effective component can be prepared by a method which comprises the step of immersing the mushroom in a hydrophilic solvent at a temperature ranging from 60.degree. to 1000.degree. C. for 15 minutes to 2 hours to perform extraction. The extract can further be treated to obtain the effective components in the form of powder. The extract and the powder thereof can be used as an effective component of a deodorizer capable of oral intake, which serves as a deodorizer for preventing bad smell of environment or an agent for preventing foul breath, which can also be used in foods for eating or drinking to prevent giving out of bad smell emitted from cookings such as those containing garlic and leek as well as cooked fish, which can prevents giving out of bad smell after taking such cookings, and which can be involved in metabolism to thus suppress the giving out of bad smell from urine and feces discharged after eating and drinking such foods.

摘要翻译： 除臭剂包括香菇的果实的亲水性溶剂提取物或提取物的粉末作为有效成分。 用作有效成分的香菇菇的提取物可以通过包括以下步骤的方法制备：将蘑菇浸入亲水性溶剂中，温度为60〜1000℃，15分钟〜2小时，进行萃取。 可以进一步处理提取物以获得粉末形式的有效成分。 提取物及其粉末可以用作能够口服的除臭剂的有效成分，其作为用于防止恶臭气味的除臭剂或用于防止臭味的药剂，其也可用于食用食品或 饮用以防止排出的诸如含有大蒜和韭菜的烹饪物质以及煮熟的鱼类产生的不良气味，其可以防止在进行这种烹饪之后发出不良气味，并且可以参与新陈代谢从而抑制发出 食用和饮用这些食物后尿液和粪便排出的气味很差。