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    Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus
    3.
    发明申请
    Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus 审中-公开
    用于预防和治疗更年期症状的组合物，其包含槐提取物

    公开(公告)号：US20070087064A1

    公开(公告)日：2007-04-19

    申请号：US10580469

    申请日：2004-02-09

    申请人： Suk-Hyung Kwon ,  Bo-Sik Hwang ,  Kuk-Hwan Kim ,  Seung-Hwan Lee ,  Eun-Ju Yoon ,  Seung-Hee Lee ,  Min-Won Lee ,  Do-Ik Lee ,  Yung-Wook Choi ,  Seong-Soo Joo ,  Tae-Joon Won ,  Hee-Chul Kang

    发明人： Suk-Hyung Kwon ,  Bo-Sik Hwang ,  Kuk-Hwan Kim ,  Seung-Hwan Lee ,  Eun-Ju Yoon ,  Seung-Hee Lee ,  Min-Won Lee ,  Do-Ik Lee ,  Yung-Wook Choi ,  Seong-Soo Joo ,  Tae-Joon Won ,  Hee-Chul Kang

    IPC分类号： A61K36/489

    CPC分类号： A61K36/489

    摘要： The present invention relates to a composition for preventing and treating climacteric symptoms comprising the extract of Sophorae Fructus as an effective ingredient. Precisely, the present invention relates to the extract of Sophorae Fructus having an effect of preventing and treating climacteric symptoms, a composition comprising the extract and a method for preventing and treating climacteric symptoms by administering the composition. The extract of Sophorae Fructus of the present invention has activities of promoting the osteoblast proliferation, inhibiting the secretion of bone-absorptive cytokines, promoting the secretion of growth factors involved in bone-reformation, stimulating the generation of nitric oxide in osteoblasts and inhibiting the osteoclast differentiation. In addition, the extract also reduces the concentration of a bone absorption index and inhibits the decrease of calcium content and bone density. Therefore, the extract of Sophorae Fructus of the present invention can be effectively used for the prevention and the treatment of climacteric symptoms including osteoporosis.

    摘要翻译： 本发明涉及一种用于预防和治疗更年期症状的组合物，其包含作为有效成分的苦参提取物。 正是本发明涉及具有预防和治疗更年期症状的苦参的提取物，包含该提取物的组合物和通过施用该组合物来预防和治疗更年期症状的方法。 本发明的苦参提取物具有促进成骨细胞增殖，抑制骨吸收性细胞因子分泌的活性，促进参与骨重建的生长因子的分泌，刺激成骨细胞产生一氧化氮并抑制破骨细胞 差异化 此外，提取物还降低骨吸收指数的浓度，并抑制钙含量和骨密度的降低。 因此，本发明的苦参提取物可以有效地用于预防和治疗包括骨质疏松症的更年期症状。