METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE
    3.
    发明申请
    METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE 有权
    制备光学活性1-溴-1- [3,5-BIS(三氟甲基)苯基]乙烯的方法

    公开(公告)号:US20130190540A1

    公开(公告)日:2013-07-25

    申请号:US13811651

    申请日:2011-07-21

    IPC分类号: C07C17/04

    摘要: A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R1)(R2)(R3) (in the formula, R1, R2, and R3 independently represent a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxy group), or (c) a combination of N-bromosuccinimide and a dialkyl sulfide.

    摘要翻译: 一种具有高光学纯度的光学活性1-溴-1- [3,5-双(三氟甲基) - 苯基]乙烷的制备方法,其包括将光学活性的1- [3,5-双(三氟甲基) 苯基]乙醇通过使用溴化剂,(a)卤化磷和溴化氢的组合,(b)1,2-二溴-1,1,2,2-四氯乙烷与有机磷化合物的组合 由通式(I)表示:P(R1)(R2)(R3)(在式中,R1,R2和R3独立地表示C6-10芳基,C6-10芳氧基,C1-10 烷基,C1-10烷氧基,C3-6环烷基或C3-6环烷氧基),或(c)N-溴代琥珀酰亚胺与二烷基硫醚的组合。

    Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane
    4.
    发明授权
    Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane 有权
    光学活性1-溴-1 [3,5-双(三氟甲基)苯基]乙烷的制备方法

    公开(公告)号:US09272966B2

    公开(公告)日:2016-03-01

    申请号:US13811651

    申请日:2011-07-21

    摘要: A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R1)(R2)(R3) (in the formula, R1, R2, and R3 independently represent a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxy group), or (c) a combination of N-bromosuccinimide and a dialkyl sulfide.

    摘要翻译: 一种具有高光学纯度的光学活性1-溴-1- [3,5-双(三氟甲基) - 苯基]乙烷的制备方法,其包括将光学活性的1- [3,5-双(三氟甲基) 苯基]乙醇通过使用溴化剂,(a)卤化磷和溴化氢的组合,(b)1,2-二溴-1,1,2,2-四氯乙烷与有机磷化合物的组合 由通式(I)表示:P(R1)(R2)(R3)(在式中,R1,R2和R3独立地表示C6-10芳基,C6-10芳氧基,C1-10 烷基,C1-10烷氧基,C3-6环烷基或C3-6环烷氧基),或(c)N-溴代琥珀酰亚胺与二烷基硫醚的组合。

    METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE
    7.
    发明申请
    METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE 审中-公开
    制备5- [2-(甲氧基)乙氧基]吡嗪-2-胺的方法

    公开(公告)号:US20110166351A1

    公开(公告)日:2011-07-07

    申请号:US13063095

    申请日:2009-09-11

    IPC分类号: C07D239/47

    摘要: A novel method for preparing 5-[2-(methylthio)ethoxy]pyrimidin-2-amine useful as a regent or raw material for manufacture of medicaments, agricultural chemicals, and industrial products, which comprises alkanoylating the amino group of a 2-amino-4-alkoxypyrimidine, then converting the resultant into a 4-hydroxypyrimidine compound by a treatment with anhydrous aluminum chloride, further etherifying the 4-hydroxypyrimidine compound by a reaction with a 2-haloethyl methyl sulfide in the presence of a base, and removing the alkanoyl group to obtain 5-[2-(methylthio)ethoxy]pyrimidin-2-amine.

    摘要翻译: 一种制备用作制备药物,农药和工业产品的摄取剂或原料的5- [2-(甲硫基)乙氧基]嘧啶-2-胺的新方法,其包括将2-氨基的氨基烷酰化 -4-烷氧基嘧啶,然后通过用无水氯化铝处理将所得物转化成4-羟基嘧啶化合物,在碱的存在下,通过与2-卤代乙基甲基硫醚的反应醚化4-羟基嘧啶化合物,并除去 烷酰基,得到5- [2-(甲硫基)乙氧基]嘧啶-2-胺。