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1.发明授权Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth 有权用于刺激骨和软骨生长的合成三萜类化合物和三环双烯酮公开(公告)号：US08299046B2
公开(公告)日：2012-10-30
申请号：US11941723
申请日：2007-11-16
申请人： Michael B. Sporn , Karen T. Liby , Tadashi Honda , Gregory Mundy , Ross Garrett , Hari Reddi , Gordon W. Gribble , Takahiro Niikura
发明人： Michael B. Sporn , Karen T. Liby , Tadashi Honda , Gregory Mundy , Ross Garrett , Hari Reddi , Gordon W. Gribble , Takahiro Niikura
IPC分类号： C07D233/02
CPC分类号： A61K31/4164 , A61K9/00 , A61K31/26 , A61K31/277 , A61K35/32 , A61K38/1841 , C12N5/0655 , C12N2501/999 , Y02A50/395 , A61K2300/00
摘要： The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
摘要翻译： 本发明涉及使用合成三萜类化合物和三环双酮刺激骨和软骨的生长和修复的方法。 合适的三萜类化合物的实例包括CDDO，CDDO-Me，CDDO-Im和CDDO-乙酰胺。 三环双酮的实例包括TBE-31和TBE-34。
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2.发明申请SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH 有权用于刺激骨骼和体重增长的合成三磷酸酯和三聚体双酚A公开(公告)号：US20080233195A1
公开(公告)日：2008-09-25
申请号：US11941723
申请日：2007-11-16
申请人： Michael B. Spoorn , Karen T. Liby , Tadashi Honda , Gordon Gribble , Gregory Mundy , Ross Garrett , Hari Reddi , Takahiro Niikura
发明人： Michael B. Spoorn , Karen T. Liby , Tadashi Honda , Gordon Gribble , Gregory Mundy , Ross Garrett , Hari Reddi , Takahiro Niikura
IPC分类号： A61K9/00 , C12N5/00 , A61K31/122 , A61P19/00 , A61K35/12
CPC分类号： A61K31/4164 , A61K9/00 , A61K31/26 , A61K31/277 , A61K35/32 , A61K38/1841 , C12N5/0655 , C12N2501/999 , Y02A50/395 , A61K2300/00
摘要： The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
摘要翻译： 本发明涉及使用合成三萜类化合物和三环双酮来刺激骨和软骨的生长和修复的方法。 合适的三萜类化合物的实例包括CDDO，CDDO-Me，CDDO-Im和CDDO-乙酰胺。 三环双酮的实例包括TBE-31和TBE-34。
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3.发明申请THERAPEUTIC AGENT FOR BONE FRACTURE COMPRISING CARBON DIOXIDE AS AN ACTIVE INGREDIENT 审中-公开用于将二氧化碳作为活性成分的骨折的治疗剂公开(公告)号：US20140127120A1
公开(公告)日：2014-05-08
申请号：US14130571
申请日：2012-07-13
申请人： Keisuke Oe , Takahiro Niikura , Masahiko Miwa , Takeshi Ueha , Masaya Tanaka
发明人： Keisuke Oe , Takahiro Niikura , Masahiko Miwa , Takeshi Ueha , Masaya Tanaka
CPC分类号： A61K33/00 , A61K9/0014
摘要： The present invention provides a prophylactic or therapeutic agent for fracture and bone diseases as well as a bone growth promoting agent containing carbon dioxide as an active ingredient. Further, according to the present invention, an additive or synergistic effect for preventing or treating fracture and bone diseases as well as for promoting bone growth by combining the therapeutic agent of the present invention and a bone absorption inhibitor and/or a bone formation promoter is obtained.
摘要翻译： 本发明提供骨折和骨疾病的预防或治疗剂以及含有二氧化碳作为活性成分的骨生长促进剂。 此外，根据本发明，通过组合本发明的治疗剂和骨吸收抑制剂和/或骨形成促进剂来合成预防或治疗骨折和骨疾病以及促进骨生长的添加剂或协同效应是 获得。
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