公开(公告)号：US20060135401A1

公开(公告)日：2006-06-22

申请号：US10519678

申请日：2003-07-07

申请人： Takao Fujimura ,  Hiroaki Mori ,  Katsuhiko Yoshizawa ,  Yoko Takata ,  Ichiro Aramori ,  Hideaki Matsuoka ,  Akira Unami ,  Takahisa Noto

发明人： Takao Fujimura ,  Hiroaki Mori ,  Katsuhiko Yoshizawa ,  Yoko Takata ,  Ichiro Aramori ,  Hideaki Matsuoka ,  Akira Unami ,  Takahisa Noto

IPC分类号： A61K38/17 ,  G01N33/567

CPC分类号： C12Q1/6897 ,  C12Q1/6883 ,  G01N33/5047 ,  G01N33/6869 ,  G01N33/6872 ,  G01N2333/55

摘要： The invention relates to a novel method for selecting an immunosuppressive agent with a less thrombocytopenia effect. According to the invention, a method for selecting an immunosuppressive agent which has a potent immunosuppressive activity but a lower thrombocytopenia effect, said method comprising measuring an IL-2 transcription inhibitory activity in a test cell in to which an IL-2 reporter gene has been introduced in the coexistence of an analyte, while measuring a GATA-1 transcription inhibitory activity in the test cell into which a GATA-1 reporter gene has been introduced in the coexistence of an analyte, and comparing both the transcription inhibitory activities, is provided.

摘要翻译： 本发明涉及一种选择血小板减少作用较小的免疫抑制剂的新方法。 根据本发明，一种选择具有有效的免疫抑制活性但较低的血小板减少症的免疫抑制剂的方法，所述方法包括测量IL-2转录抑制活性，其中IL-2报告基因已被 在分析物共存的同时测量在分析物共存中引入了GATA-1报道基因的测试细胞中的GATA-1转录抑制活性，并比较两种转录抑制活性。

公开(公告)号：US20110201659A1

公开(公告)日：2011-08-18

申请号：US13125100

申请日：2009-10-19

申请人： Hiroshi Suzuki ,  Koji Chono ,  Takahisa Noto ,  Kiyomitsu Katsumata ,  Yoichi Nakamura

发明人： Hiroshi Suzuki ,  Koji Chono ,  Takahisa Noto ,  Kiyomitsu Katsumata ,  Yoichi Nakamura

IPC分类号： A61K31/4245 ,  A61P25/00

CPC分类号： A61K31/382 ,  A61K31/4245 ,  C07D413/12

摘要： The present invention relates to a pharmaceutical composition and method for preventing or treating a zoster-associated pain. The inventors found that an N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide compound useful as a varicella-zoster virus (VZV) unexpectedly has the effect to prevent an irreversible nerve degeneration accompanied by herpes virus infection, and therefore is also useful as an agent for preventing or treating zoster-associated pain, and thus accomplished the present invention.

摘要翻译： 本发明涉及用于预防或治疗带状疱疹相关性疼痛的药物组合物和方法。 本发明人发现用作水痘带状疱疹病毒（VZV）的N- {2 - [（4-取代苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺化合物意外地具有预防作用 伴有疱疹病毒感染的不可逆的神经变性，因此也可用作预防或治疗带状疱疹相关疼痛的药剂，从而完成了本发明。