利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.016 秒)

    Agent for inducing apoptosis
    1.
    发明授权
    Agent for inducing apoptosis 失效
    诱导细胞凋亡的药物

    公开(公告)号：US06548536B2

    公开(公告)日：2003-04-15

    申请号：US09793654

    申请日：2001-02-27

    申请人： Mitsunobu Hara ,  Takayuki Nakashima ,  Yutaka Kanda ,  Masami Hamano ,  Shun-ichi Ikeda ,  Yuko Uosaki ,  Yoko Takata ,  Junji Kanazawa

    发明人： Mitsunobu Hara ,  Takayuki Nakashima ,  Yutaka Kanda ,  Masami Hamano ,  Shun-ichi Ikeda ,  Yuko Uosaki ,  Yoko Takata ,  Junji Kanazawa

    IPC分类号： A61K3134

    CPC分类号： C07D407/14 ,  A61K31/00 ,  A61K31/365 ,  C07H17/08

    摘要： Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient (---- represents a single bond or a double bond; j and k represent 0 or 1; R1 to R3, R7 to R10 and R14 represent a hydrogen atom, a lower alkyl group and the like; R4, R11, R12, R13 and R15 to R18 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like; R5 and R6 represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a group represented by the following formula (B) (R32 represents a formyl group and the like, R33 to R35 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like); R19 represents a hydroxyl group, a lower alkoxyl group, a lower alkanoyloxy group and the like). The agents are useful as medicaments for preventive and/or therapeutic treatment of diseases resulting from increased expression of Bcl-2 family proteins, for example, cancers, AIDS and the like.

    摘要翻译： 用于诱导凋亡的药剂，其包含由下式（I）表示的四环卟啉衍生物或其盐作为活性成分（----表示单键或双键; j和k表示0或1; R 1至R 3， R 7〜R 10和R 14表示氢原子，低级烷基等; R 4，R 11，R 12，R 13，R 15〜R 18表示氢原子，羟基，低级烷基等; R 5，R 6表示 氢原子，羟基，低级烷基，下式（B）表示的基团（R32表示甲酰基等，R33〜R35表示氢原子，羟基，低级烷基， 类似）; R 19表示羟基，低级烷氧基，低级烷酰氧基等）。 这些药剂可用作预防和/或治疗由Bcl-2家族蛋白（例如癌症，AIDS等）表达增加而引起的疾病的药物。

    Hematopoietic stem cell proliferating agents
    2.
    发明授权
    Hematopoietic stem cell proliferating agents 失效
    造血干细胞增殖剂

    公开(公告)号：US06495365B1

    公开(公告)日：2002-12-17

    申请号：US09147689

    申请日：1999-05-13

    申请人： Yoshimasa Saito ,  Yoshiko Ueda ,  Kouichi Tamura ,  Yoko Takata ,  Hisashi Yamada ,  Tatsuo Yamashita ,  Masakazu Kobayashi

    发明人： Yoshimasa Saito ,  Yoshiko Ueda ,  Kouichi Tamura ,  Yoko Takata ,  Hisashi Yamada ,  Tatsuo Yamashita ,  Masakazu Kobayashi

    IPC分类号： C12N500

    CPC分类号： A61K38/30 ,  A61K2300/00

    摘要： This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy.

    摘要翻译： 本发明涉及造血干细胞增殖剂，其包含IGF-I，包含IGF-I的造血干细胞增殖剂和选自SCF，M-CSF和G-CSF中的至少一种蛋白质，以及造血造血干细胞增殖的方法 干细胞，其包括在含有IGF-I和至少一种选自SCF和M-CSF的蛋白质的培养基中培养造血干细胞。本发明的造血干细胞增殖剂引起造血干细胞在未分化的细胞中增殖 说明是否在体内或体外，因此可以用于改善由放射治疗或化疗引起的血细胞减少症，使用抗癌药物，预防与淋巴细胞减少有关的感染性疾病，或体外培养造血干细胞和外植体培养物 基因治疗中的重组干细胞。