公开(公告)号：US20090318787A1

公开(公告)日：2009-12-24

申请号：US12486843

申请日：2009-06-18

申请人： Takuo AOYAGI ,  Michio KANEMOTO ,  Masayoshi FUSE ,  Teiji UKAWA

发明人： Takuo AOYAGI ,  Michio KANEMOTO ,  Masayoshi FUSE ,  Teiji UKAWA

IPC分类号： A61B5/1455

CPC分类号： A61B5/7207 ,  A61B5/1455

摘要： A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.

摘要翻译： 脉搏血氧测定法包括：用多个不同波长的光束照射生物体组织; 接收通过生物体组织传播或反射的光束，并将接收的光束转换成对应于不同波长的电信号; 时间分段电信号的时间序列数据; 针对电信号的每个分段时间序列数据计算每个两个电信号之间的回归线的斜率值; 根据电信号分段时间序列数据的斜率值计算SaO2; 为每个预定数量的时间段构建SaO2的直方图; 并且从直方图获得作为脉搏血氧饱和度的SpO2的模式值。

公开(公告)号：US20050049469A1

公开(公告)日：2005-03-03

申请号：US10927016

申请日：2004-08-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.

摘要翻译： 在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。 光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。 第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。 第二计算器根据五个衰减变化计算出至少四个衰减变化率。 每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。 第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

公开(公告)号：US06230035B1

公开(公告)日：2001-05-08

申请号：US09356521

申请日：1999-07-19

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Chen-tai Xie ,  Michio Kanemoto

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Chen-tai Xie ,  Michio Kanemoto

IPC分类号： A61B500

CPC分类号： A61B5/14551 ,  A61B5/14552

摘要： Irradiating device 3 of a pulse oximeter includes a scattering plate 6. Scattering light is projected into a living tissue. The diameter of the incident area is sufficiently large compared with that of a light receiving area or vice versa. Therefore, tissue terms in a theoretical formula of &PHgr; which represents a ratio of changes of optical densities of tissue measured with two wavelengths are not dependent on the wavelength. The digital processor 10 calculates an oxygen saturation by substituting &PHgr; measured into simultaneous equations.

摘要翻译： 脉搏血氧计的照射装置3包括散射板6.散射光投射到活体组织中。 与光接收区域相比，入射面积的直径足够大，反之亦然。 因此，理论公式中的组织术语＆PHgr; 其表示用两个波长测量的组织的光密度变化的比率不依赖于波长。 数字处理器10用“PHgr”代替氧饱和度; 测量为联立方程。

公开(公告)号：US5999841A

公开(公告)日：1999-12-07

申请号：US916295

申请日：1997-08-22

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B6/00 ,  A61B5/02

CPC分类号： A61B5/0275

摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

摘要翻译： 使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

公开(公告)号：US5690104A

公开(公告)日：1997-11-25

申请号：US661169

申请日：1996-06-10

申请人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

发明人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/6826 ,  A61B5/14551 ,  A61B5/6838 ,  A61B2560/0209

摘要： Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.

摘要翻译： 在第一时间段内测量透过活体组织的两种不同波长的光的强度。 数据处理器使用对应于在第一时间段期间测量的光强度的对数处理数据来确定第一回归线。 操作者将染料注入到生物体中，并且在稍后的时间段内测量两种不同波长的光的强度。 数据处理器使用对应于在稍后时间段内测量的光强度的对数处理的数据来确定第二回归线。 数据处理器找到两条回归线的交点，并使用交点确定无血性水平点。 然后处理器形成掺有无血型水平点数据的染料稀释曲线。

公开(公告)号：US5385143A

公开(公告)日：1995-01-31

申请号：US14269

申请日：1993-02-05

申请人： Takuo Aoyagi

发明人： Takuo Aoyagi

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： Disclosed is an apparatus for measuring a predetermined data of a living tissue, such as an oxygen saturation, a dye dilution curve and level of hemoglobin. The apparatus has an illumination intensity computing and storing circuit that stores the intensities of light components emitted from a three-wavelength light source assembly, and a computing circuit that calculates the intensity ratios of illuminating light from the intensity data stored in the circuit. The circuit determines the predetermined data of blood on the basis of the calculated intensity ratios and the intensities of light transmitted through a living tissue under assay, and it displays the predetermined data on display unit. The apparatus is capable of measuring the predetermined data without relying upon pulsations that occur in the subject.

摘要翻译： 公开了一种用于测量活组织的预定数据的装置，例如氧饱和度，染料稀释曲线和血红蛋白水平。 该装置具有照射强度计算和存储电路，其存储从三波长光源组件发射的光分量的强度，以及计算电路，其根据存储在电路中的强度数据计算照明光的强度比。 该电路基于计算的强度比和通过测定的活体组织透射的光的强度来确定血液的预定数据，并且在显示单元上显示预定数据。 该装置能够测量预定数据而不依赖于在对象中发生的脉动。

公开(公告)号：US5313940A

公开(公告)日：1994-05-24

申请号：US882960

申请日：1992-05-14

申请人： Masayoshi Fuse ,  Cheng T. Xie ,  Takuo Aoyagi

发明人： Masayoshi Fuse ,  Cheng T. Xie ,  Takuo Aoyagi

IPC分类号： A61B5/024 ,  A61B5/00

CPC分类号： A61B5/6826 ,  A61B5/02416 ,  A61B5/6838

摘要： A photo-electric pulse measuring probe includes a pair of supporting members which have a light emitting element and a light receiving element adjacent first end portions thereof, respectively, in such a manner that the light emitting element and the light receiving elements are confronted with each other, and which are swingably coupled to each other at the other end portions thereof. The light emitting element and the light receiving element are covered with elastic members, respectively, and wavy surfaces are formed in the mating surfaces of the elastic members, respectively, so that a user's finger is supported by a number of points during measurement.

摘要翻译： 光电脉冲测量探头包括分别具有发光元件和光接收元件的第一端部的一对支撑构件，使得发光元件和光接收元件分别与每个 并且在其另一端部可摆动地彼此耦合。 发光元件和受光元件分别被弹性构件覆盖，并且分别在弹性构件的配合表面中形成波状表面，使得用户的手指在测量期间由多个点支撑。

公开(公告)号：US5766125A

公开(公告)日：1998-06-16

申请号：US429545

申请日：1995-04-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

IPC分类号： G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31

CPC分类号： A61B5/14551 ,  G01N21/3151

摘要： Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.

摘要翻译： 从发光装置发射的不同波长的光束通过活组织透射。 透射光束由光电转换装置转换为电信号。 脉动计算装置根据光电转换装置的输出信号，计算各波长的生物体组织的吸光度的脉动。 通过使用这一点，脉动比计算装置计算吸光度值的脉动比。 浓度计算装置将脉动比计算装置的输出信号设置在组织术语上具有单个未知数的公式中，其基于在各个波长的组织项之间存在预定关系的事实构成， 从而计算组织术语的值和血液中光吸收材料的浓度。

公开(公告)号：US5278627A

公开(公告)日：1994-01-11

申请号：US835505

申请日：1992-02-14

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Yoshiaki Shindo ,  Masayuki Kato

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Yoshiaki Shindo ,  Masayuki Kato

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/27 ,  G01N33/00 ,  G01N33/487 ,  G01N33/48

CPC分类号： G01N21/274 ,  A61B5/02427 ,  A61B5/14551 ,  A61B5/1495 ,  A61B2560/0233

摘要： An apparatus for calibrating a pulse oximeter which can improve the repetitivity of measured values for calibration tests and which can calibrate the pulse oximeter with a high reliability. A tissue model having a light-absorbing characteristic approximated to that of the tissue of a living body is inserted into a space between a light-emitting section and a light-receiving section of a measuring probe that is connected to the pulse oximeter, and a blood model having a light-absorbing characteristic that is approximated to that of the blood is moved within the tissue model so as to enter into or exit from the space between the light-emitting section and the light-receiving section.

摘要翻译： 用于校准脉搏血氧计的装置，其可以提高校准测试的测量值的重复性，并且可以以高可靠性校准脉搏血氧计。 将具有近似于生物体组织的光吸收特性的组织模型插入连接到脉搏血氧计的测量探针的发光部分和光接收部分之间的空间中，并且 具有近似于血液的光吸收特性的血液模型在组织模型内移动，以进入或离开发光部分和光接收部分之间的空间。

公开(公告)号：US08024021B2

公开(公告)日：2011-09-20

申请号：US11511476

申请日：2006-08-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： To measure oxygen saturation in blood, living tissue is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the tissue. The first electrical signal is divided into a plurality of first segments, each including a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments, each including a part of the second electrical signal for the predetermined time period. A gradient of a regression line is calculated between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.

摘要翻译： 为了测量血液中的氧饱和度，用具有第一波长的第一光束和具有第二波长的第二光束照射活组织。 从从组织反射或透过组织的第一光束产生第一电信号。 从从组织反射或透过组织的第二光束产生第二电信号。 第一电信号被分成多个第一段，每个第一段包括第一电信号的一部分预定时间段。 第二电信号被分成多个第二段，每个第二段包括预定时间段的第二电信号的一部分。 在第一段和第二段中的每一个之间计算回归线的梯度，从而获得多个梯度。