公开(公告)号：US5766125A

公开(公告)日：1998-06-16

申请号：US429545

申请日：1995-04-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

IPC分类号： G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31

CPC分类号： A61B5/14551 ,  G01N21/3151

摘要： Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.

摘要翻译： 从发光装置发射的不同波长的光束通过活组织透射。 透射光束由光电转换装置转换为电信号。 脉动计算装置根据光电转换装置的输出信号，计算各波长的生物体组织的吸光度的脉动。 通过使用这一点，脉动比计算装置计算吸光度值的脉动比。 浓度计算装置将脉动比计算装置的输出信号设置在组织术语上具有单个未知数的公式中，其基于在各个波长的组织项之间存在预定关系的事实构成， 从而计算组织术语的值和血液中光吸收材料的浓度。

公开(公告)号：US5697371A

公开(公告)日：1997-12-16

申请号：US358381

申请日：1994-12-19

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B5/00

CPC分类号： A61B5/0275

摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

摘要翻译： 使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

公开(公告)号：US5999841A

公开(公告)日：1999-12-07

申请号：US916295

申请日：1997-08-22

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B6/00 ,  A61B5/02

CPC分类号： A61B5/0275

摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

摘要翻译： 使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

公开(公告)号：US5690104A

公开(公告)日：1997-11-25

申请号：US661169

申请日：1996-06-10

申请人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

发明人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/6826 ,  A61B5/14551 ,  A61B5/6838 ,  A61B2560/0209

摘要： Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.

摘要翻译： 在第一时间段内测量透过活体组织的两种不同波长的光的强度。 数据处理器使用对应于在第一时间段期间测量的光强度的对数处理数据来确定第一回归线。 操作者将染料注入到生物体中，并且在稍后的时间段内测量两种不同波长的光的强度。 数据处理器使用对应于在稍后时间段内测量的光强度的对数处理的数据来确定第二回归线。 数据处理器找到两条回归线的交点，并使用交点确定无血性水平点。 然后处理器形成掺有无血型水平点数据的染料稀释曲线。

公开(公告)号：US20050049469A1

公开(公告)日：2005-03-03

申请号：US10927016

申请日：2004-08-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.

摘要翻译： 在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。 光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。 第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。 第二计算器根据五个衰减变化计算出至少四个衰减变化率。 每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。 第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

公开(公告)号：US08024021B2

公开(公告)日：2011-09-20

申请号：US11511476

申请日：2006-08-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： To measure oxygen saturation in blood, living tissue is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the tissue. The first electrical signal is divided into a plurality of first segments, each including a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments, each including a part of the second electrical signal for the predetermined time period. A gradient of a regression line is calculated between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.

摘要翻译： 为了测量血液中的氧饱和度，用具有第一波长的第一光束和具有第二波长的第二光束照射活组织。 从从组织反射或透过组织的第一光束产生第一电信号。 从从组织反射或透过组织的第二光束产生第二电信号。 第一电信号被分成多个第一段，每个第一段包括第一电信号的一部分预定时间段。 第二电信号被分成多个第二段，每个第二段包括预定时间段的第二电信号的一部分。 在第一段和第二段中的每一个之间计算回归线的梯度，从而获得多个梯度。

公开(公告)号：US07206621B2

公开(公告)日：2007-04-17

申请号：US10927016

申请日：2004-08-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.

摘要翻译： 在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。 光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。 第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。 第二计算器根据五个衰减变化计算出至少四个衰减变化率。 每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。 第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

公开(公告)号：US20070049812A1

公开(公告)日：2007-03-01

申请号：US11511476

申请日：2006-08-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： In order to measure an oxygen saturation in blood of a subject, a living tissue of the subject is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength different from the first wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the living tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the living tissue. The first electrical signal is divided into a plurality of first segments each of which includes a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments each of which includes a part of the second electrical signal for the predetermined time period. It is calculated a gradient of a regression line between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.

摘要翻译： 为了测量对象的血液中的氧饱和度，用具有第一波长的第一光束和具有不同于第一波长的第二波长的第二光束照射被检体的活体组织。 从从生物体组织反射或透过活体组织的第一光束产生第一电信号。 从通过活体组织反射或透过的第二光束产生第二电信号。 第一电信号被分成多个第一段，每个第一段在预定时间段内包括第一电信号的一部分。 第二电信号被分成多个第二段，每个第二段包括预定时间段的第二电信号的一部分。 计算出每个第一段和第二段之间的回归线的梯度，从而获得多个梯度。

公开(公告)号：US06415236B1

公开(公告)日：2002-07-02

申请号：US09725865

申请日：2000-11-30

申请人： Naoki Kobayashi ,  Michio Kanemoto ,  Takashi Usuda ,  Teiji Ukawa

发明人： Naoki Kobayashi ,  Michio Kanemoto ,  Takashi Usuda ,  Teiji Ukawa

IPC分类号： A61B500

摘要： An apparatus for determining concentrations of hemoglobins additionally uses a light source 3 which emits light of a third wavelength in an orangy red wavelength region of 590 to 660 nm. The apparatus includes light receiving means 6 for receiving lights that are emitted by the light sources and transmitted through or reflected by a living tissue, attenuation ratio processing means 15 for processing attenuation ratios &PHgr; on the wavelengths based on variations of signals associated with the wavelengths output from the light receiving means, which variations are caused by a pulsation of blood, and concentration ratio processing means 16 for processing concentration ratios of at least oxyhemoglobin, deoxyhemoglobin and carboxyhemoglobin based on the output signals from the attenuation ratio processing means. The apparatus thus constructed can properly measure carboxyhemoglobin COHb, and present its concentration display and an alarm display in a simple manner, which is clinically effective.

公开(公告)号：US06622095B2

公开(公告)日：2003-09-16

申请号：US10075623

申请日：2002-02-15

申请人： Naoki Kobayashi ,  Takashi Usuda ,  Michio Kanemoto ,  Yoshiaki Takamura ,  Teiji Ukawa

发明人： Naoki Kobayashi ,  Takashi Usuda ,  Michio Kanemoto ,  Yoshiaki Takamura ,  Teiji Ukawa

IPC分类号： A61B500

CPC分类号： A61B5/14551

摘要： An apparatus for determining concentrations of hemoglobins includes a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region, light receiving device for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue, attenuation ratio processing device for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving device, the variations are caused by a pulsation of blood and concentration ratio processing device for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing device.