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1.发明授权公开(公告)号：US10907001B2
公开(公告)日：2021-02-02
申请号：US15760830
申请日：2016-09-19
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08G75/02 , C08G75/20 , C08F228/02 , C08G85/00 , C08G81/00 , C08G75/23 , C08G75/0286 , C08L81/00 , C08G75/00 , A61L27/16 , A61L29/04 , A61L31/04 , C08F236/04 , C08F299/02 , C08K5/41 , C08G75/04 , C08G75/045 , A61L27/54 , A61L29/16 , A61L31/16
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
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2.发明申请公开(公告)号：US20180258207A1
公开(公告)日：2018-09-13
申请号：US15760830
申请日：2016-09-19
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08F228/02 , C08F236/04 , C08F299/02 , C08K5/41 , A61L27/16 , A61L29/04 , A61L31/04
CPC分类号： C08F228/02 , A61L27/16 , A61L27/54 , A61L29/041 , A61L29/16 , A61L31/048 , A61L31/16 , C08F236/04 , C08F299/022 , C08F2810/30 , C08G75/00 , C08G75/0286 , C08G75/23 , C08G81/00 , C08G85/004 , C08K5/41 , C08L81/00
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
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公开(公告)号：US06923986B2
公开(公告)日：2005-08-02
申请号：US10650163
申请日：2003-08-27
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08G65/32 , A61K9/00 , A61K9/107 , A61K9/127 , A61K9/14 , A61K9/20 , A61K9/51 , A61K9/70 , A61K38/17 , A61K47/32 , A61K47/34 , A61K48/00 , A61L15/58 , A61L15/60 , A61L24/00 , A61L24/04 , C08F299/02 , C08G18/40 , C08G63/00 , C08G63/672 , C08G65/329 , C08L71/02 , A61K31/765 , C08L53/00
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US06410645B1
公开(公告)日：2002-06-25
申请号：US09710416
申请日：2000-11-09
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： A61K31765
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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6.发明授权
公开(公告)号：US4650614A
公开(公告)日：1987-03-17
申请号：US402254
申请日：1982-07-27
IPC分类号： C07C309/04 , C07C143/02
CPC分类号： C07C303/44
摘要： Reaction grade 2-acrylamido-2-methylpropane sulfonic acid is refined by mildly heating a slurry-like suspension formed of the acid and a liquid monohydric alcohol, recovering the acid from the alcohol and subsequently drying it.
摘要翻译： 通过温和加热由酸和液体一元醇形成的淤浆状悬浮液来精制反应级2-丙烯酰氨基-2-甲基丙磺酸，从醇中回收酸，随后将其干燥。
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公开(公告)号：US20110305872A1
公开(公告)日：2011-12-15
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译： 一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有 在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟 。
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公开(公告)号：US6162241A
公开(公告)日：2000-12-19
申请号：US129735
申请日：1998-08-05
IPC分类号： A61L27/00 , A61K9/16 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , C08G63/676 , C08G65/00 , C08G85/00 , A61B17/08
CPC分类号： C08G63/676 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61L2300/418 , A61L2400/04 , C08G63/64 , C08L67/04
摘要： A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can control bleeding at the site and may also provide improved adherence of the sealant to tissue and provide shorter healing times.
摘要翻译： 一种通过在组织密封剂组合物中应用止血剂来控制止血的方法。 组织密封剂是可生物降解的生物相容性合成聚合物，其本身不具有强的止血性能。 将止血材料包括在组织密封剂中可以控制该部位的渗血并且还可以提供密封剂对组织的改善的粘附并提供更短的愈合时间。
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9.发明授权Redox and photoinitiator systems for priming and improved adherence of gels to substrates 失效氧化还原和光引发剂体系，用于引发和改善凝胶对底物的粘附
公开(公告)号：US6121341A
公开(公告)日：2000-09-19
申请号：US973077
申请日：1997-10-10
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08K1/00 , A61F2/00
CPC分类号： C09D4/00 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/904
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。 出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。
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公开(公告)号：US5662712A
公开(公告)日：1997-09-02
申请号：US483194
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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