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公开(公告)号：US12054719B2
公开(公告)日：2024-08-06
申请号：US16099153
申请日：2017-04-28
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIV. TRINITY OF QUEEN ELIZABETH NEARD DUBLIN , IMPERIAL COLLEGE INNOVATIONS LIMITED , DUKE UNIVERSITY
发明人： Peter Humphries , Marian Humphries , Matthew Campbell , Anna-Sophia Kiang , Daniel Stamer , Darryl Ray Overby , Chi Shing Lawrence Tam
IPC分类号： C07H21/02 , A61P27/06 , C07H21/04 , C12N15/113
CPC分类号： C12N15/1138 , A61P27/06 , C12N15/113 , C12N2310/122 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12N2320/32
摘要： The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.
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公开(公告)号：US20230285531A1
公开(公告)日：2023-09-14
申请号：US17959546
申请日：2022-10-04
申请人： The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy
发明人： Kingston MILLS , Aisling DUNNE
IPC分类号： A61K39/02 , A61K39/39 , C07K14/705
CPC分类号： A61K39/099 , A61K39/39 , C07K14/705 , A61K2039/57
摘要： The present invention relates to Toll-Like Receptor 2 (TLR2) agonists, in particular, to TLR2-activating lipoproteins, and more particularly to TLR2-activating lipopeptides derived from the bacteria Bordetella pertussis. The invention further extends to the use of said TLR2-activating lipoproteins as a therapeutic or as part of a vaccine composition in the treatment and prevention of infectious diseases, cancer or allergic diseases.
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公开(公告)号：US11136459B2
公开(公告)日：2021-10-05
申请号：US16323149
申请日：2017-08-03
发明人： Conor Boland , Umar Khan , Jonathan Coleman
摘要： A homogenous composite material with increased tensile strength comprising 2-dimensional nano-sheets exfoliated from a 3-dimensional layered material mixed in a liquid non-Newtonian viscoelastic material to produce the homogenous composite material; and a process for making the same.
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公开(公告)号：US20210100666A1
公开(公告)日：2021-04-08
申请号：US17109003
申请日：2020-12-01
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY
发明人： Conor Harkin , Garrett Ryan , Bruce Murphy , James Redmond
摘要： An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.
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5.发明申请公开(公告)号：US20170135830A1
公开(公告)日：2017-05-18
申请号：US15351282
申请日：2016-11-14
申请人： The Provost, Fellows, Foundation Scholars, & The Other Members of Board, of the College of the Holy
发明人： Conor Harkin , Ryan Garrett , Bruce Murphy , James Redmond , Michael Burke , Riona Ni Ghriallais
CPC分类号： A61F2/86 , A61B1/307 , A61F2/04 , A61F2/848 , A61F2/966 , A61F2002/047 , A61F2002/825 , A61F2002/8483 , A61F2002/9665 , A61F2210/0004 , A61F2230/0013 , A61F2230/0023 , A61F2230/0054 , A61F2230/0056 , A61F2230/0067 , A61F2230/0069 , A61F2230/0095 , A61F2250/0039 , A61F2250/0067 , A61M29/02
摘要： An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.
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公开(公告)号：US11925673B2
公开(公告)日：2024-03-12
申请号：US17471446
申请日：2021-09-10
发明人： Matthew Campbell , Sarah Doyle , Natalie Hudson , Lucia Celkova
CPC分类号： A61K38/1709 , A61K9/0048
摘要： The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.
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7.发明公开公开(公告)号：US20230381274A1
公开(公告)日：2023-11-30
申请号：US18028240
申请日：2021-09-25
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY
发明人： MATTHEW CAMPBELL , CHRIS GREEN , NATALIE HUDSON , COLIN DOHERTY
CPC分类号： A61K38/177 , A61K48/0058 , C12N2750/14143
摘要： The present invention relates to a tight junction (zonulae occludentes) protein for use in treating or preventing epilepsy. Also disclosed are a vector comprising a first nucleic acid encoding a tight junction protein operatively linked to a second nucleic acid comprising an endothelial- cell-specific promoter for use in treating or preventing epilepsy. The tight junction protein is preferably a claudin-5 protein.
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公开(公告)号：US11158560B2
公开(公告)日：2021-10-26
申请号：US16644297
申请日：2018-09-04
IPC分类号： H01L23/36 , H01L23/367 , H01L21/48 , H01L23/373 , C23C24/04
摘要： A thermal structure for dissipating heat from a semiconductor substrate has a semiconductor substrate having an external surface which may be roughened. An optional base layer comprising aluminium is formed on top of the external surface by a cold spraying process, and a top layer comprising a matrix of copper and diamond is formed above the substrate, and above the base layer if present, by cold spraying a powder mixture of copper and diamond particles. The top layer is thereby created as a matrix of copper formed by the deformation of the copper particles on impact with the underlying surface and a dispersed phase comprising the diamond particles embedded within the copper matrix. The resulting structure has high thermal conductivity and a coefficient of thermal expansion that is well matched to the substrate, and eliminates the need for a thermal interface material or paste.
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公开(公告)号：US20200016236A1
公开(公告)日：2020-01-16
申请号：US16335441
申请日：2017-09-22
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY
发明人： Matthew CAMPBELL , Sarah DOYLE , Natalie HUDSON , Lucia CLEKOVA
IPC分类号： A61K38/17
摘要： The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.
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公开(公告)号：US10029056B2
公开(公告)日：2018-07-24
申请号：US14424964
申请日：2013-08-29
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIV. TRINITY OF QUEEN ELIZABETH NEAR DUBLIN , ROYAL COLLEGE OF SURGEONS IN IRELAND
发明人： Richard Reilly , Richard Costello , Cian Hughes , Ehsan Chah , Isabelle Killane
IPC分类号： A61M15/00
摘要： A system and method suitable for monitoring user technique of an inhaler device configured for delivery of a medicament is provided. The system may include a microphone adapted for sensing sound made during operation of the inhaler device and processing circuitry operable to process a data signal obtained from the microphone, wherein the data signal includes acoustic information sensed. The processing circuitry is adapted to determine inhalation and exhalation breath characteristics that occur during use, by analyzing the temporal and spectral components of the acoustic information sensed and processed to differentiate between an inhalation and an exhalation, based on both the temporal and spectral components. This information can be processed to determine user technique adherence to inhaler or respiratory device protocol. The analysis of temporal and spectral components can determine the impact of user technique errors on the quantity and the deposition of medicament delivered into the user's airways.
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