-
公开(公告)号：US5536823A
公开(公告)日：1996-07-16
申请号：US147637
申请日：1993-11-03
IPC分类号： C07H19/06 , C07H21/00 , C07H19/073 , C07H19/16 , C07H19/173
摘要： Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as are methods for preparing the precursors and analogues.
摘要翻译： RNA和DNA化合物的类似物含有基于用磺酰基取代磷酰基的中性立体定向连接基团。 还描述了类似物的前体，以及制备前体和类似物的方法。
-
公开(公告)号：US5321030A
公开(公告)日：1994-06-14
申请号：US812561
申请日：1991-12-20
申请人： Rima Kaddurah-Daouk , James W. Lillie , Theodore S. Widlanski , Jonathan J. Burbaum , Craig J. Forsyth
发明人： Rima Kaddurah-Daouk , James W. Lillie , Theodore S. Widlanski , Jonathan J. Burbaum , Craig J. Forsyth
IPC分类号： A61K31/195 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07D239/14 , C07D487/04 , C07F9/22 , C07F9/6506 , C07K14/82 , C12N9/12 , C12N15/113 , C12Q1/50 , G01N33/574 , A01N43/54 , A01N43/50
CPC分类号： C07D487/04 , A61K31/195 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K31/685 , A61K31/70 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07F9/222 , C07F9/65061 , C07K14/82 , C12N15/1137 , C12N9/12 , C12Q1/50 , C12Y207/0102 , C12Y207/03002 , C12Y207/04003 , C12Y406/01001 , G01N33/57484 , A61K38/00 , A61K48/00 , G01N2333/01
摘要： The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to creatine analogs including four classes of creatine analogs selected as candidate antiviral compounds: (1) creatine analogs that can be phosphorylated by creatine kinase but differ in their phosphoryl group transfer potential, (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine, (3) creatine analogs which can act as irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.
摘要翻译： 本发明涉及肌酸类似物如环磷酸的用途，作为抗病毒剂。 肌酸类似物可用作抗病毒剂，用于各种病毒，特别是DNA病毒，例如疱疹病毒（例如HSV-1，HSV-2，巨细胞病毒，水痘带状疱疹病毒）和腺病毒。 本发明还涉及肌酸类似物，其包括选择为候选抗病毒化合物的四类肌酸类似物：（1）可以由肌酸激酶磷酸化但磷酸转移电位不同的肌酸类似物，（2）包含共价的肌酸激酶双底物抑制剂 腺苷三磷酸（ATP）和肌酸的连接结构类似物，（3）可以作为肌酸激酶不可逆抑制剂的肌酸类似物，和（4）具有模拟N-磷酰基的不可转移部分的N-磷酸肌醇类似物。
-
公开(公告)号：US5714361A
公开(公告)日：1998-02-03
申请号：US194838
申请日：1994-02-14
摘要： Described are preferred suicide inhibitors of phosphatase or phosphodiesterase enzymes, and methods for preparing halo enol phosphates which can serve as such suicide inhibitors.
摘要翻译： 描述了优选的磷酸酶或磷酸二酯酶的自杀抑制剂，以及可用作这种自杀抑制剂的卤代烯醇磷酸盐的制备方法。
-
公开(公告)号：US6117988A
公开(公告)日：2000-09-12
申请号：US792346
申请日：1997-01-31
CPC分类号： C07H21/00
摘要： Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as are methods for preparing the precursors and analogues.
摘要翻译： RNA和DNA化合物的类似物含有基于用磺酰基取代磷酰基的中性立体定向连接基团。 还描述了类似物的前体，以及制备前体和类似物的方法。
-
-
-
搜索结果
4 条记录 (耗时 0.012 秒)
