-
公开(公告)号：US5321030A
公开(公告)日：1994-06-14
申请号：US812561
申请日：1991-12-20
申请人： Rima Kaddurah-Daouk , James W. Lillie , Theodore S. Widlanski , Jonathan J. Burbaum , Craig J. Forsyth
发明人： Rima Kaddurah-Daouk , James W. Lillie , Theodore S. Widlanski , Jonathan J. Burbaum , Craig J. Forsyth
IPC分类号： A61K31/195 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07D239/14 , C07D487/04 , C07F9/22 , C07F9/6506 , C07K14/82 , C12N9/12 , C12N15/113 , C12Q1/50 , G01N33/574 , A01N43/54 , A01N43/50
CPC分类号： C07D487/04 , A61K31/195 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K31/685 , A61K31/70 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07F9/222 , C07F9/65061 , C07K14/82 , C12N15/1137 , C12N9/12 , C12Q1/50 , C12Y207/0102 , C12Y207/03002 , C12Y207/04003 , C12Y406/01001 , G01N33/57484 , A61K38/00 , A61K48/00 , G01N2333/01
摘要： The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to creatine analogs including four classes of creatine analogs selected as candidate antiviral compounds: (1) creatine analogs that can be phosphorylated by creatine kinase but differ in their phosphoryl group transfer potential, (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine, (3) creatine analogs which can act as irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.
摘要翻译： 本发明涉及肌酸类似物如环磷酸的用途，作为抗病毒剂。 肌酸类似物可用作抗病毒剂，用于各种病毒，特别是DNA病毒，例如疱疹病毒（例如HSV-1，HSV-2，巨细胞病毒，水痘带状疱疹病毒）和腺病毒。 本发明还涉及肌酸类似物，其包括选择为候选抗病毒化合物的四类肌酸类似物：（1）可以由肌酸激酶磷酸化但磷酸转移电位不同的肌酸类似物，（2）包含共价的肌酸激酶双底物抑制剂 腺苷三磷酸（ATP）和肌酸的连接结构类似物，（3）可以作为肌酸激酶不可逆抑制剂的肌酸类似物，和（4）具有模拟N-磷酰基的不可转移部分的N-磷酸肌醇类似物。
-
2.发明授权
公开(公告)号：US5324731A
公开(公告)日：1994-06-28
申请号：US610418
申请日：1990-11-07
IPC分类号： A61K38/55 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K38/00 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D233/46 , C07D233/60 , C07D233/88 , C07D239/04 , C07D239/14 , C07D303/36 , C07H19/20 , C07K14/82 , C12N9/12 , C12N15/09 , C12N15/113 , C12N15/54 , C12Q1/50 , G01N33/573 , G01N33/574 , A01N43/54 , A01N43/50
CPC分类号： A61K31/00 , A61K31/195 , A61K31/415 , A61K31/505 , A61K31/66 , C07K14/82 , C12N15/1137 , C12N9/12 , C12N9/1223 , C12Q1/50 , C12Y207/0102 , C12Y207/03002 , C12Y207/04003 , C12Y406/01001 , G01N33/573 , G01N33/57484 , A61K38/00 , A61K48/00 , G01N2333/01
摘要： A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism or regulation of nucleotide levels or the relative ratios of their phosphorylated states, is elevated. In particular, a method of inhibiting transformation, growth and/or metastasis of mammalian cells in which a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells has acted.
摘要翻译： 抑制哺乳动物细胞，特别是上皮细胞的生长，转化和/或转移的方法，其中参与嘌呤代谢或调节核苷酸水平的至少一种酶或其磷酸化状态的相对比例的活性升高。 特别地，抑制哺乳动物细胞的转化，生长和/或转移的方法，其中DNA肿瘤病毒，DNA肿瘤病毒因子或其他对细胞具有等效作用的因子起作用。
-
公开(公告)号：US06337183B1
公开(公告)日：2002-01-08
申请号：US08709342
申请日：1996-09-06
申请人： Jaime E. Arenas , James W. Lillie , Andrew Pakula
发明人： Jaime E. Arenas , James W. Lillie , Andrew Pakula
IPC分类号： C12Q168
CPC分类号： C12Q1/6811 , C12N15/1048 , C12Q1/6818 , C12Q1/701 , C40B40/06 , C40B50/06 , C12Q2565/1015 , C12Q2525/301
摘要： The present invention provides methods for high-throughput screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve measuring the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA conformation.
-
4.发明授权公开(公告)号：US06569628B2
公开(公告)日：2003-05-27
申请号：US09961008
申请日：2001-09-20
IPC分类号： C12Q168
CPC分类号： C40B30/10 , C12N15/1048 , C12Q1/6811 , C12Q1/6813 , C12Q1/6816 , C40B40/06 , C40B50/06 , C12Q2561/119
摘要： The present invention provides methods for screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve assessing the stability and/or the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA stability and/or conformation. In a preferred embodiment, the effect of a ligand on target RNA stability and/or conformation is assessed by measuring the fluorescence polarization of a fluorescently labeled probe.
-
5.发明授权Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids 失效筛选采用荧光各向异性以鉴定对核酸具有亲和性的化合物公开(公告)号：US06331392B1
公开(公告)日：2001-12-18
申请号：US09060449
申请日：1998-03-05
IPC分类号： C12Q168
CPC分类号： C40B30/10 , C12N15/1048 , C12Q1/6811 , C12Q1/6813 , C12Q1/6816 , C40B40/06 , C40B50/06 , C12Q2561/119
摘要： The present invention provides methods for screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve assessing the stability and/or the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA stability and/or conformation. In a preferred embodiment, the effect of a ligand on target RNA stability and/or conformation is assessed by measuring the fluorescence polarization of a fluorescently labeled probe.
摘要翻译： 本发明提供用于筛选生物活性化合物的方法，特别是结合涉及疾病发病机理或调节生理功能的RNA序列的方法。 所述方法包括在存在和不存在测试配体的情况下评估RNA靶标的稳定性和/或构象，以及鉴定导致靶RNA稳定性和/或构象可测量变化的任何测试配体。 在优选的实施方案中，通过测量荧光标记的探针的荧光偏振来评估配体对靶RNA稳定性和/或构象的影响。
-
公开(公告)号：US06503721B2
公开(公告)日：2003-01-07
申请号：US09962432
申请日：2001-09-24
申请人： Jaime E. Arenas , James W. Lillie , Andrew Pakula
发明人： Jaime E. Arenas , James W. Lillie , Andrew Pakula
IPC分类号： C12Q168
CPC分类号： C12Q1/6811 , C12N15/1048 , C12Q1/6818 , C12Q1/701 , C40B40/06 , C40B50/06 , C12Q2565/1015 , C12Q2525/301
摘要： The present invention provides methods for high-throughput screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve measuring the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA conformation.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.026 秒)
