公开(公告)号：US20180142266A1

公开(公告)日：2018-05-24

申请号：US15579442

申请日：2016-06-10

申请人： Thomas Haas ,  Anja Hecker ,  Stefan Gilch ,  Thomas Bülter

发明人： Thomas Haas ,  Anja Hecker ,  Stefan Gilch ,  Thomas Bülter

IPC分类号： C12P7/04 ,  C12N9/02 ,  C12N9/04 ,  C12P7/16

CPC分类号： C12P7/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12N15/52 ,  C12P7/16 ,  C12P7/40 ,  C12P7/62 ,  C12Y101/01001 ,  C12Y102/0101 ,  Y02E50/10

摘要： There is provided a microbial cell which is capable of producing at least one higher alcohol, wherein the microbial cell is genetically modified to include an increased expression relative to its wild type cell of at least one acyl-CoA reductase (E11). In particular, there is provided a microbial cell capable of producing at least one higher alcohol, wherein the microbial cell is genetically modified to include an increased expression relative to its wild type cell of at least one acyl-CoA reductase (E11) and wherein the cell is capable of producing a carboxylic acid and/or ester thereof using ethanol-carboxylate fermentation.

公开(公告)号：US20180066297A1

公开(公告)日：2018-03-08

申请号：US15551904

申请日：2016-02-16

申请人： Thomas Haas ,  Thomas Bülter ,  Stefan Buchholz ,  Simon Beck

发明人： Thomas HAAS ,  Thomaas BÜLTER ,  Stefan BUCHHOLZ ,  Simon BECK

IPC分类号： C12P19/44 ,  C12N9/10 ,  C12N9/14

CPC分类号： C12P19/44 ,  C12N9/1051 ,  C12N9/14

摘要： There is provided a method of producing at least one rhamnolipid comprising: (a) contacting a recombinant cell with a medium containing a carbon source; wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E1, E2 and E3, wherein the enzyme E1 is an α/β hydrolase (RHIA), the enzyme E2 is a rhamnosyltransferase I (RHIB) and the enzyme E3 is a rhamnosyltransferase II (RHIC), and wherein the carbon source is an alkane and/or alkanoic acid comprising 6 to 10 carbon atoms.