公开(公告)号：US08124354B2

公开(公告)日：2012-02-28

申请号：US12602321

申请日：2008-04-25

申请人： Christian Probst ,  Wolfgang Schlumberger ,  Winfried Stöcker ,  Cornelia Dähnrich ,  Lars Komorowski ,  Thomas Mothes

发明人： Christian Probst ,  Wolfgang Schlumberger ,  Winfried Stöcker ,  Cornelia Dähnrich ,  Lars Komorowski ,  Thomas Mothes

IPC分类号： G01N33/53

CPC分类号： C07K14/415 ,  C07K2319/00 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/202 ,  G01N2800/24

摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.

摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。

公开(公告)号：US20100203558A1

公开(公告)日：2010-08-12

申请号：US12602321

申请日：2008-04-25

申请人： Christian Probst ,  Wolfgang Schlumberger ,  Winfried Stöcker ,  Cornelia Dähnrich ,  Lars Komorowski ,  Thomas Mothes

发明人： Christian Probst ,  Wolfgang Schlumberger ,  Winfried Stöcker ,  Cornelia Dähnrich ,  Lars Komorowski ,  Thomas Mothes

IPC分类号： G01N33/53 ,  C07K14/00 ,  G01N33/564 ,  C07H21/00

CPC分类号： C07K14/415 ,  C07K2319/00 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/202 ,  G01N2800/24

摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.

摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。