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1.发明申请POLYPEPTIDES AND METHODS FOR THE SPECIFIC DETECTION OF ANTIBODIES IN PATIENTS WITH A BORRELIA INFECTION 有权用于特异性检测患有BORRELIA感染的患者抗体的多肽和方法公开(公告)号：US20120177680A1
公开(公告)日：2012-07-12
申请号：US13427181
申请日：2012-03-22
CPC分类号： G01N33/56911 , A61K39/00 , C07K14/195 , G01N2333/20 , G01N2469/20
摘要： The present disclosure relates to proteins derived from OspC from bacteria of the genus Borrelia, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide bridge. The disclosure also relates to a method for the detection of antibodies against OspC and a method for the detection of a Borrelia infection, wherein a protein according to the disclosure is employed, and also to a diagnostic kit and a vaccine against Borrelia.
摘要翻译： 本公开涉及来自疏螺旋体属细菌的OspC的蛋白质，特别是包含第一OspC多肽的蛋白质，其中第一OspC多肽通过二硫桥与第二OspC多肽连接。 本公开还涉及用于检测针对OspC的抗体的方法和用于检测Borrelia感染的方法，其中使用根据本公开的蛋白质，以及诊断试剂盒和针对Borrelia的疫苗。
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2.发明授权Polypeptides and methods for the specific detection of antibodies in patients with a borrelia infection 有权多肽和方法用于特异性检测患有Borrelia感染的患者的抗体公开(公告)号：US08431135B2
公开(公告)日：2013-04-30
申请号：US13427181
申请日：2012-03-22
IPC分类号： A61K39/02
CPC分类号： G01N33/56911 , A61K39/00 , C07K14/195 , G01N2333/20 , G01N2469/20
摘要： The present disclosure relates to proteins derived from OspC from bacteria of the genus Borrelia, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide bridge. The disclosure also relates to a method for the detection of antibodies against OspC and a method for the detection of a Borrelia infection, wherein a protein according to the disclosure is employed, and also to a diagnostic kit and a vaccine against Borrelia.
摘要翻译： 本公开涉及来自疏螺旋体属细菌的OspC的蛋白质，特别是包含第一OspC多肽的蛋白质，其中第一OspC多肽通过二硫桥与第二OspC多肽连接。 本公开还涉及用于检测针对OspC的抗体的方法和用于检测Borrelia感染的方法，其中使用根据本公开的蛋白质，以及诊断试剂盒和针对Borrelia的疫苗。
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3.发明授权Polypeptides and methods for the specific detection of antibodies in patients with a Borrelia infection 有权用于特异性检测Borrelia感染患者抗体的多肽和方法公开(公告)号：US08163500B2
公开(公告)日：2012-04-24
申请号：US12636530
申请日：2009-12-11
IPC分类号： G01N33/53
CPC分类号： G01N33/56911 , A61K39/00 , C07K14/195 , G01N2333/20 , G01N2469/20
摘要： The present disclosure relates to proteins derived from OspC from bacteria of the genus Borrelia, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide bridge. The disclosure also relates to a method for the detection of antibodies against OspC and a method for the detection of a Borrelia infection, wherein a protein according to the disclosure is employed, and also to a diagnostic kit and a vaccine against Borrelia.
摘要翻译： 本公开涉及来自疏螺旋体属细菌的OspC的蛋白质，特别是包含第一OspC多肽的蛋白质，其中第一OspC多肽通过二硫桥与第二OspC多肽连接。 本公开还涉及用于检测针对OspC的抗体的方法和用于检测Borrelia感染的方法，其中使用根据本公开的蛋白质，以及诊断试剂盒和针对Borrelia的疫苗。
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4.发明授权Method and immunoabsorbents for specific detection and absorption of antibodies associated with celiac disease and dermatitis herpetiformis 有权用于特异性检测和吸收与腹腔疾病和疱疹样皮炎相关的抗体的方法和免疫吸附剂公开(公告)号：US08124354B2
公开(公告)日：2012-02-28
申请号：US12602321
申请日：2008-04-25
申请人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
发明人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
IPC分类号： G01N33/53
CPC分类号： C07K14/415 , C07K2319/00 , G01N33/564 , G01N33/6854 , G01N2800/202 , G01N2800/24
摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.
摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。
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5.发明申请METHOD AND IMMUNE ABSORBENTS FOR THE SPECIFIC DETECTION AND ABSORPTION OF CELIAC DISEASE-AND HERPETIFORM DERMATITIS-ASSOCIATED ANTIBODIES 有权用于特异性检测和吸收CELIAC疾病和HERβTIFORMDERMATITIS相关抗体的方法和免疫吸收剂公开(公告)号：US20100203558A1
公开(公告)日：2010-08-12
申请号：US12602321
申请日：2008-04-25
申请人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
发明人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
IPC分类号： G01N33/53 , C07K14/00 , G01N33/564 , C07H21/00
CPC分类号： C07K14/415 , C07K2319/00 , G01N33/564 , G01N33/6854 , G01N2800/202 , G01N2800/24
摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.
摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。
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6.发明申请POLYPEPTIDES AND METHODS FOR THE SPECIFIC DETECTION OF ANTIBODIES IN PATIENTS WITH A BORRELIA INFECTION 有权用于特异性检测患有BORRELIA感染的患者抗体的多肽和方法公开(公告)号：US20100150964A1
公开(公告)日：2010-06-17
申请号：US12636530
申请日：2009-12-11
IPC分类号： A61K39/02 , C07K14/195 , G01N33/53 , A61P31/04
CPC分类号： G01N33/56911 , A61K39/00 , C07K14/195 , G01N2333/20 , G01N2469/20
摘要： The present disclosure relates to proteins derived from OspC from bacteria of the genus Borrelia, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide bridge. The disclosure also relates to a method for the detection of antibodies against OspC and a method for the detection of a Borrelia infection, wherein a protein according to the disclosure is employed, and also to a diagnostic kit and a vaccine against Borrelia.
摘要翻译： 本公开涉及来自疏螺旋体属细菌的OspC的蛋白质，特别是包含第一OspC多肽的蛋白质，其中第一OspC多肽通过二硫桥与第二OspC多肽连接。 本公开还涉及用于检测针对OspC的抗体的方法和用于检测Borrelia感染的方法，其中使用根据本公开的蛋白质，以及诊断试剂盒和针对Borrelia的疫苗。
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7.发明申请Diagnosis of Inflammatory Bowel Diseases, More Particularly Ulcerative Colitis 审中-公开炎症性肠病诊断，尤其是溃疡性结肠炎公开(公告)号：US20080293625A1
公开(公告)日：2008-11-27
申请号：US10599942
申请日：2005-04-15
CPC分类号： G01N33/6893 , C07K14/705 , C07K16/28 , G01N2800/065
摘要： The present invention concerns goblet cell antigen, a method for detecting antibodies directed against goblet cell antigen, a method based thereon for diagnosis of inflammatory bowel diseases and a kit for diagnosis of inflammatory bowel diseases, as well as monoclonal antibodies directed against goblet cell antigen.
摘要翻译： 本发明涉及杯状细胞抗原，用于检测针对杯状细胞抗原的抗体的方法，其中用于诊断炎症性肠病的方法和用于诊断炎症性肠病的试剂盒，以及针对杯状细胞抗原的单克隆抗体。
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