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1.发明授权Method and immunoabsorbents for specific detection and absorption of antibodies associated with celiac disease and dermatitis herpetiformis 有权用于特异性检测和吸收与腹腔疾病和疱疹样皮炎相关的抗体的方法和免疫吸附剂公开(公告)号：US08124354B2
公开(公告)日：2012-02-28
申请号：US12602321
申请日：2008-04-25
申请人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
发明人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
IPC分类号： G01N33/53
CPC分类号： C07K14/415 , C07K2319/00 , G01N33/564 , G01N33/6854 , G01N2800/202 , G01N2800/24
摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.
摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。
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2.发明申请METHOD AND IMMUNE ABSORBENTS FOR THE SPECIFIC DETECTION AND ABSORPTION OF CELIAC DISEASE-AND HERPETIFORM DERMATITIS-ASSOCIATED ANTIBODIES 有权用于特异性检测和吸收CELIAC疾病和HERβTIFORMDERMATITIS相关抗体的方法和免疫吸收剂公开(公告)号：US20100203558A1
公开(公告)日：2010-08-12
申请号：US12602321
申请日：2008-04-25
申请人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
发明人： Christian Probst , Wolfgang Schlumberger , Winfried Stöcker , Cornelia Dähnrich , Lars Komorowski , Thomas Mothes
IPC分类号： G01N33/53 , C07K14/00 , G01N33/564 , C07H21/00
CPC分类号： C07K14/415 , C07K2319/00 , G01N33/564 , G01N33/6854 , G01N2800/202 , G01N2800/24
摘要： The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.
摘要翻译： 本发明涉及衍生自麦醇溶蛋白成分的融合肽，通过测定针对修饰的麦醇溶蛋白的抗体，用于血清学诊断乳糜泻或疱疹样皮炎的方法和试剂。 本发明还涉及通过这些抗体的特异性免疫吸收来治疗所述疾病的方法和药物组合物。
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3.发明授权Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (DLE) 有权制备核小体制剂的方法及其在体外诊断系统性红斑狼疮（SLE）中的应用公开(公告)号：US07566545B2
公开(公告)日：2009-07-28
申请号：US10504569
申请日：2002-12-02
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/564 , C07K14/4713 , C12N15/1003 , C12P21/00 , G01N33/6875 , G01N2800/104
摘要： Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or delaying the onset of a rise in blood glucose levels in an animal, comprising administering to the animal an antisense inhibitor of PTP1B expression in combination with at least one glucose-lowering drug. The present invention is also directed to compositions and methods for improving insulin sensitivity in an animal or for preventing or delaying the onset of insulin resistance in an animal. Also provided are compositions and methods for treating or preventing a metabolic condition in an animal. The metabolic condition may be, e.g., diabetes or obesity.
摘要翻译： 本发明涉及一种制备核小体制剂的方法，其特征在于适用于针对人样品中针对核小体的特异性抗体的免疫荧光测定，因此用于诊断系统性红斑狼疮（SLE），更具体地比较 与最先进的技术。
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