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公开(公告)号：US20110124514A1
公开(公告)日：2011-05-26
申请号：US12051765
申请日：2008-03-19
申请人： Carol E. Zhou , Adam T. Zemla , Marisa W. Lam , Jason R. Smith , Elizabeth A. Vitalis , Shea N. Gardner , Thomas A. Kuczmarski , Thomas R. Slezak , Diane C. Roe , Joseph P. Schoeniger , Clinton L. Torres
发明人： Carol E. Zhou , Adam T. Zemla , Marisa W. Lam , Jason R. Smith , Elizabeth A. Vitalis , Shea N. Gardner , Thomas A. Kuczmarski , Thomas R. Slezak , Diane C. Roe , Joseph P. Schoeniger , Clinton L. Torres
CPC分类号： G16B20/00
摘要： A set of known protein sequences associated with an organism is identified, wherein each known protein sequence comprises a plurality of ordered residues. A set of scores associated with a set of residues of the plurality of ordered residues is identified, wherein each score indicates a frequency of a residue in sequence context. A set of unique sub-sequences of the set of known protein sequences is identified. A plurality of protein signature residues is determined based on the set of scores associated with the set of residues and the set of unique sub-sequences.
摘要翻译： 鉴定与生物体相关的一组已知蛋白质序列，其中每个已知的蛋白质序列包含多个有序残基。 识别与多个有序残基的一组残基相关联的分数集合，其中每个分数指示序列上下文中残基的频率。 鉴定了该组已知蛋白质序列的一组独特子序列。 基于与残差集合和唯一子序列集相关联的分数集合来确定多个蛋白质特征残基。
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2.发明授权Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis 有权特异于土拉弗朗西斯菌的核苷酸序列和用于检测土拉弗朗西斯氏菌的方法公开(公告)号：US07494778B2
公开(公告)日：2009-02-24
申请号：US11644669
申请日：2006-12-21
申请人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Elizabeth A Vitalis
发明人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Elizabeth A Vitalis
CPC分类号： C12Q1/689 , Y10S435/975
摘要： Described herein is the identification of nucleotide sequences specific to Francisella tularensis that serves as a marker or signature for identification of this bacterium. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of the bacterium are disclosed.
摘要翻译： 本文描述了用作鉴定该细菌的标记或签名的弗朗西斯氏菌特异性的核苷酸序列的鉴定。 此外，公开了用于检测细菌存在的核苷酸检测方法中使用的来自这些核苷酸序列的正向和反向引物和杂交探针。
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公开(公告)号：US20110070586A1
公开(公告)日：2011-03-24
申请号：US12842952
申请日：2010-07-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q2600/16
摘要： Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample.
摘要翻译： 描述了用于检测样品中农业病原体的试剂盒和方法。 分析来自农业病原体的基因组序列信息以鉴定特征序列，例如可用于确认样品中病原体存在或不存在的多核苷酸序列。 引物和探针组被设计和优化用于基于PCR的多重Luminex测定和/或阵列测定以成功鉴定样品中病原体的存在或不存在。
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4.发明授权Nucleotide sequences specific to Yersinia pestis and methods for the detection of Yersinia pestis 有权鼠疫耶尔森氏菌特异性的核苷酸序列和用于检测鼠疫耶尔森疫霉的方法公开(公告)号：US07494772B2
公开(公告)日：2009-02-24
申请号：US10630536
申请日：2003-07-29
申请人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Vladinir L. Motin
发明人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Vladinir L. Motin
摘要： Nucleotide sequences specific to Yersinia pestis that serve as markers or signatures for identification of this bacterium were identified. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of the bacterium are disclosed.
摘要翻译： 鉴定了用作鉴定该细菌的标记或特征的鼠疫耶尔森菌特异性的核苷酸序列。 此外，公开了用于检测细菌存在的核苷酸检测方法中使用的来自这些核苷酸序列的正向和反向引物和杂交探针。
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5.发明申请BIOLOGICAL SAMPLE TARGET CLASSIFICATION, DETECTION AND SELECTION METHODS, AND RELATED ARRAYS AND OLIGONUCLEOTIDE PROBES 审中-公开生物样本目标分类，检测和选择方法以及相关的阵列和寡核苷酸探针公开(公告)号：US20110152109A1
公开(公告)日：2011-06-23
申请号：US12643903
申请日：2009-12-21
摘要： Biological sample target classification, detection and selection methods are described, together with related arrays and oligonucleotide probes.
摘要翻译： 描述生物样品靶分类，检测和选择方法以及相关阵列和寡核苷酸探针。
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6.发明授权Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis 失效特异于土拉弗朗西斯菌的核苷酸序列和用于检测土拉弗朗西斯氏菌的方法公开(公告)号：US07172868B2
公开(公告)日：2007-02-06
申请号：US10630154
申请日：2003-07-29
申请人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Elizabeth A Vitalis
发明人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski , Elizabeth A Vitalis
CPC分类号： C12Q1/689 , Y10S435/975
摘要： Described herein is the identification of nucleotide sequences specific to Francisella tularensis that serves as a marker or signature for identification of this bacterium. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of the bacterium are disclosed.
摘要翻译： 本文描述了用作鉴定该细菌的标记或签名的弗朗西斯氏菌特异性的核苷酸序列的鉴定。 此外，公开了用于检测细菌存在的核苷酸检测方法中使用的来自这些核苷酸序列的正向和反向引物和杂交探针。
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7.发明授权Nucleotide sequences specific to Brucella and methods for the detection of Brucella 有权Brucella特异性的核苷酸序列和Brucella检测方法公开(公告)号：US07494773B2
公开(公告)日：2009-02-24
申请号：US10630607
申请日：2003-07-29
申请人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski
发明人： Paula M. McCready , Lyndsay Radnedge , Gary L. Andersen , Linda L. Ott , Thomas R. Slezak , Thomas A. Kuczmarski
摘要： Nucleotide sequences specific to Brucella that serves as a marker or signature for identification of this bacterium were identified. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of the bacterium are disclosed.
摘要翻译： 鉴定了作为用于鉴定该细菌的标记或签名的布鲁杆菌特异性的核苷酸序列。 此外，公开了用于检测细菌存在的核苷酸检测方法中使用的来自这些核苷酸序列的正向和反向引物和杂交探针。
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