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公开(公告)号：US06849424B2
公开(公告)日：2005-02-01
申请号：US10365677
申请日：2003-02-12
摘要： The invention relates to devices and methods for growing cells in vitro in an enclosed device that allows for a three-dimensional measurement over time of both their proliferative and/or invasive properties. By growing the cells in an enclosed matrix that resembles the environment that the cells confront in vivo, the cells can divide, invade, and form branched networks as they do in living tissue, e.g., in an individual. The devices of the invention include a test chamber in which cells, e.g., tumor cells, are placed and permitted to divide and/or invade. Cells can be placed within an insert within a chamber of the device. A delivery chamber that connects to the test chamber enables the delivery of agents that can be studied, e.g., for their therapeutic potential. The assay devices of the invention can be used as model systems to study cancer biology and to evaluate the efficacy of anti-cancer therapeutics.
摘要翻译： 本发明涉及用于在封闭装置中体外培养细胞的装置和方法，所述装置和方法允许随着时间的推移进行三维测量，包括它们的增殖和/或侵入性质。 通过将细胞生长在类似于细胞在体内所面临的环境的封闭的基质中，细胞可如在活组织中例如在个体中分开，侵入并形成分支的网络。 本发明的装置包括测试室，其中放置例如肿瘤细胞的细胞并允许分裂和/或侵入细胞。 细胞可以放置在装置的腔室内的插入物内。 连接到测试室的输送室能够输送可以研究的药剂，例如用于其治疗潜力。 本发明的测定装置可用作模型系统来研究癌症生物学并评估抗癌治疗剂的功效。
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公开(公告)号：US06602701B2
公开(公告)日：2003-08-05
申请号：US09758644
申请日：2001-01-11
IPC分类号： C12M300
摘要： The invention relates to devices and methods for growing cells in vitro in an enclosed device that allows for a three-dimensional measurement over time of both their proliferative and/or invasive properties. By growing the cells in an enclosed matrix that resembles the environment that the cells confront in vivo, the cells can divide, invade, and form branched networks as they do in living tissue, e.g., in an individual. The devices of the invention include a test chamber in which cells, e.g., tumor cells, are placed and permitted to divide and/or invade. Cells can be placed within an insert within a chamber of the device. A delivery chamber that connects to the test chamber enables the delivery of agents that can be studied, e.g., for their therapeutic potential. The assay devices of the invention can be used as model systems to study cancer biology and to evaluate the efficacy of anti-cancer therapeutics.
摘要翻译： 本发明涉及用于在封闭装置中体外培养细胞的装置和方法，所述装置和方法允许随着时间的推移进行三维测量，包括它们的增殖和/或侵入性质。 通过将细胞生长在类似于细胞在体内所面临的环境的封闭的基质中，细胞可如在活组织中例如在个体中分开，侵入并形成分支的网络。 本发明的装置包括测试室，其中放置例如肿瘤细胞的细胞并允许分裂和/或侵入细胞。 细胞可以放置在装置的腔室内的插入物内。 连接到测试室的输送室能够输送可以研究的药剂，例如用于其治疗潜力。 本发明的测定装置可用作模型系统来研究癌症生物学并评估抗癌治疗剂的功效。
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