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公开(公告)号：US06776765B2
公开(公告)日：2004-08-17
申请号：US09934245
申请日：2001-08-21
IPC分类号： A61B500
CPC分类号： A61M25/0102 , A61B5/0086 , A61M25/0105
摘要： A steerable stylet for use within a lumen of an intravascular device includes a stylet assembly and a handle. The stylet assembly has a distal end portion and a proximal end portion and includes a stylet wire having a lumen and a core wire positioned within the lumen with the distal end portion secured to the stylet wire proximate the distal end portion of the stylet wire. The handle includes a hand-held housing structure connected to one of the proximal end portion of the stylet wire or the core wire. In one embodiment, an adjustable tensioner is connected to the other of the proximal end portion of the stylet wire or the core wire to adjust a relative tension force applied between the stylet wire and the core wire. A tension limiter is arranged to limit the tension force to a limit force that is less than a breaking stress force of the stylet wire when the stylet wire is positioned within the lumen of the intravascular device.
摘要翻译： 在血管内装置的内腔内使用的可导向的管心针包括探针组件和手柄。 探针组件具有远端部分和近端部分，并且包括具有内腔和位于内腔内的芯线的探针线，其中远端部分固定在接近探针针线的远端部分处的探针线上。 手柄包括连接到探针线或芯线的近端部分之一的手持式壳体结构。 在一个实施例中，可调式张紧器连接到探针线或芯线的近端部分中的另一个，以调节施加在通丝针线和芯线之间的相对张力。 张力限制器被布置成当张力线定位在血管内装置的内腔内时，将张力限制在小于探针线的断裂应力的极限力。
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公开(公告)号：US5684250A
公开(公告)日：1997-11-04
申请号：US517214
申请日：1995-08-21
申请人： Lawrence B. Marsh , John D. Wright
发明人： Lawrence B. Marsh , John D. Wright
IPC分类号： G01F1/00 , G01F1/58 , G01F1/66 , G01F23/14 , G01F23/284 , G01F23/292 , G01F23/296 , G01F25/00
CPC分类号： G01F1/66 , G01F1/002 , G01F1/58 , G01F23/14 , G01F23/284 , G01F23/292 , G01F23/2962
摘要： An open-channel flowmeter is calibrated by the use of local velocity and level characteristics existing at a given site, as measured by the flowmeter itself. Stored reference relationships that have been either theoretically or experimentally derived are compared to the velocity level relationships at any particular site so as to determine a correction factor which is valid at that site so as to modify the sensed velocity to be an accurate approximation of the average velocity under those site conditions. A local velocity signal is modified so as to make it an accurate approximation of the mean velocity for open-channel flowmeters of the level/velocity type.
摘要翻译： 通过使用流量计本身测量的给定位置处存在的局部速度和水平特性来校准开放通道流量计。 将理论上或实验导出的存储的参考关系与任何特定位点处的速度级关系进行比较，以确定在该位置有效的校正因子，以将感测速度修改为平均值的精确近似值 在这些现场条件下的速度。 修改局部速度信号，以使其准确近似水平/速度类型的开放式流量计的平均速度。
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公开(公告)号：US4615742A
公开(公告)日：1986-10-07
申请号：US690544
申请日：1985-01-10
申请人： John D. Wright
发明人： John D. Wright
IPC分类号： C13K1/02
CPC分类号： C13K1/02
摘要： A progressive batch hydrolysis process for producing sugar from a lignocellulosic feedstock, comprising passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feedstock to glucose; cooling said dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, then feeding said dilute acid stream serially through a plurality of prehydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose; and cooling the dilute acid stream containing glucose after it exits the last prehydrolysis reactor.
摘要翻译： 一种用于从木质纤维素原料生产糖的进行性分批水解方法，包括使稀酸流连续流过装有所述原料的多个渗滤水解反应器，流速，温度和压力足以基本上将所有纤维素组分 葡萄糖的原料; 在离开最后一个渗滤水解反应器之后，冷却含有葡萄糖的稀酸流，然后将所述稀酸料流串联地供入多个预先水解过滤反应器中，该过滤反应器装入所述原料，流速，温度和压力足以使所有的 所述原料的半纤维素成分为葡萄糖; 并且在离开最后一个预水解反应器之后冷却含有葡萄糖的稀酸流。
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公开(公告)号：US06602701B2
公开(公告)日：2003-08-05
申请号：US09758644
申请日：2001-01-11
IPC分类号： C12M300
摘要： The invention relates to devices and methods for growing cells in vitro in an enclosed device that allows for a three-dimensional measurement over time of both their proliferative and/or invasive properties. By growing the cells in an enclosed matrix that resembles the environment that the cells confront in vivo, the cells can divide, invade, and form branched networks as they do in living tissue, e.g., in an individual. The devices of the invention include a test chamber in which cells, e.g., tumor cells, are placed and permitted to divide and/or invade. Cells can be placed within an insert within a chamber of the device. A delivery chamber that connects to the test chamber enables the delivery of agents that can be studied, e.g., for their therapeutic potential. The assay devices of the invention can be used as model systems to study cancer biology and to evaluate the efficacy of anti-cancer therapeutics.
摘要翻译： 本发明涉及用于在封闭装置中体外培养细胞的装置和方法，所述装置和方法允许随着时间的推移进行三维测量，包括它们的增殖和/或侵入性质。 通过将细胞生长在类似于细胞在体内所面临的环境的封闭的基质中，细胞可如在活组织中例如在个体中分开，侵入并形成分支的网络。 本发明的装置包括测试室，其中放置例如肿瘤细胞的细胞并允许分裂和/或侵入细胞。 细胞可以放置在装置的腔室内的插入物内。 连接到测试室的输送室能够输送可以研究的药剂，例如用于其治疗潜力。 本发明的测定装置可用作模型系统来研究癌症生物学并评估抗癌治疗剂的功效。
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5.发明授权Centerless ground feedthrough pin for an electrical power source in an implantable medical device 失效用于可植入医疗装置中的电源的无心地面馈通销
公开(公告)号：US5871513A
公开(公告)日：1999-02-16
申请号：US846772
申请日：1997-04-30
CPC分类号： H01M2/065 , A61N1/3752 , H01M6/16 , H01M2/1022 , H01M2/1066 , H01M2/30
摘要： The present invention relates to centerless grinding methods and corresponding devices such as feedthroughs for implantable medical devices and for batteries for implantable medical devices. The present invention provides certain advantages, including the elimination of longitudinal anomalies in drawn wire and increasing the reliability of implantable medical devices. In a method of the present invention, the surface of an over-size medical grade wire having a known anomaly depth is centerless ground to a depth past which those anomalies disappear. Centerless grinding of the present invention may be accomplished using an abrasive wheel and suitable coolant.
摘要翻译： 本发明涉及无心磨削方法和相应的装置，例如用于可植入医疗装置的馈通装置和用于可植入医疗装置的电池。 本发明提供了一些优点，包括消除拉丝中的纵向异常并增加可植入医疗装置的可靠性。 在本发明的方法中，具有已知异常深度的超大尺寸医用级线的表面是无心磨削至经过这些异常消失的深度。 可以使用砂轮和合适的冷却剂来实现本发明的无心磨削。
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公开(公告)号：US5851222A
公开(公告)日：1998-12-22
申请号：US23015
申请日：1998-02-11
CPC分类号： H01M2/065 , A61N1/3752 , H01M6/16 , H01M2/1022 , H01M2/1066 , H01M2/30
摘要： The present invention relates to centerless grinding methods and corresponding devices such as feedthroughs for implantable medical devices and for batteries for implantable medical devices. The present invention provides certain advantages, including the elimination of longitudinal anomalies in drawn wire and increasing the reliability of implantable medical devices. In a method of the present invention, the surface of an over-size medical grade wire having a known anomaly depth is centerless ground to a depth past which those anomalies disappear. Centerless grinding of the present invention may be accomplished using an abrasive wheel and suitable coolant.
摘要翻译： 本发明涉及无心磨削方法和相应的装置，例如用于可植入医疗装置的馈通装置和用于可植入医疗装置的电池。 本发明提供了一些优点，包括消除拉丝中的纵向异常并增加可植入医疗装置的可靠性。 在本发明的方法中，具有已知的异常深度的超大尺寸医用级线的表面是无心磨削到这些异常消失的深度。 可以使用砂轮和合适的冷却剂来实现本发明的无心磨削。
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公开(公告)号：US5217899A
公开(公告)日：1993-06-08
申请号：US572683
申请日：1990-08-24
申请人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
发明人： Alan R. Shapiro , Martha L. Gray , Luis A. Melendez , Jonathan L. Schaffer , John D. Wright , Jose G. Venegas
IPC分类号： C12M3/00
CPC分类号： C12M35/04
摘要： Disclosed is an apparatus and method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subjected in vivo. The apparatus includes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively non-uniformly applied.
摘要翻译： 公开了一种用于赋予细胞的活体培养的装置和方法，所述双轴机械力近似于细胞在体内受到的机械力。 该装置包括位移施加器，其可被致动以接触和拉伸其上安装有活细胞培养物的膜。 膜的拉伸赋予细胞双轴机械力。 这些力可以均匀地施加到细胞，或者它们可以选择性地不均匀地施加。
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公开(公告)号：US20090131904A1
公开(公告)日：2009-05-21
申请号：US11942614
申请日：2007-11-19
申请人： John D. Wright , Charles M. Berg , Robert Palme , John W. Warling
发明人： John D. Wright , Charles M. Berg , Robert Palme , John W. Warling
CPC分类号： B23K26/0869 , B23K26/0823 , B23K26/302 , B23K2101/06 , B23K2103/05 , B23K2103/14 , B23K2103/18 , B23K2103/26 , F16L11/10 , F16L11/115 , Y10T29/49826
摘要： Embodiments of the present invention provide an internally threaded tube of virtually limitless length that can be easily and reliably constructed. In one aspect, the invention provides an internally threaded tube that includes a tube casing and a coil. A ratio of the length of the tube casing to the inner diameter of the tube casing can be greater than 5:1. The coil can be positioned coaxially within the tube casing. In this position, the coil can exert a radially outward force on the inner surface of the tube casing, which can aid in bonding. A portion of the coil can be specially adapted to be bonded to the tube casing. Methods of creating internally threaded tubes and methods of spirally delivering surgical components with internally threaded tubes are also disclosed.
摘要翻译： 本发明的实施例提供了可以容易且可靠地构造的实际上无限长度的内螺纹管。 一方面，本发明提供了一种内螺纹管，其包括管壳和线圈。 管壳的长度与管壳的内径的比率可以大于5:1。 线圈可以同轴地定位在管壳内。 在该位置，线圈可以在管壳的内表面上施加径向向外的力，这可以有助于结合。 线圈的一部分可以特别适于结合到管壳体。 还公开了创建内螺纹管的方法和使用内螺纹管螺旋递送手术部件的方法。
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9.发明授权Method of centerless ground finishing of feedthrough pins for an implantable medical device 失效用于可植入医疗装置的馈通针的无心磨削整理方法
公开(公告)号：US6076017A
公开(公告)日：2000-06-13
申请号：US22321
申请日：1998-02-11
CPC分类号： H01M2/065 , A61N1/3752 , H01M6/16 , H01M2/1022 , H01M2/1066 , H01M2/30
摘要： A centerless grinding method of finishing feedthrough pins and corresponding devices for use in implantable medical devices and for components such as batteries in implantable medical devices is disclosed. The method provides certain advantages, including the elimination of longitudinal anomalies in drawn wire to thereby improve the hermeticity of implantable medical devices. In one of the preferred methods, the surface of an over-size medical grade wire having a known anomaly depth is centerless ground using an abrasive wheel and suitable coolant to a layer past which those anomalies disappear.
摘要翻译： 公开了一种用于可植入医疗装置和诸如可植入医疗装置中的电池的部件的整流穿通销和相应装置的无心磨削方法。 该方法提供了一些优点，包括消除拉丝中的纵向异常，从而提高可植入医疗装置的气密性。 在优选的方法之一中，具有已知异常深度的超大尺寸医用级线材的表面是使用砂轮和适当的冷却剂进行无心磨削，通过这些异常消失的层。
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公开(公告)号：US5385056A
公开(公告)日：1995-01-31
申请号：US183312
申请日：1994-01-19
申请人： Lawrence B. Marsh , John D. Wright
发明人： Lawrence B. Marsh , John D. Wright
CPC分类号： B67D7/08 , B67D7/16 , G01F23/0061 , G01F9/001
摘要： A pump station flowmeter is disclosed including a sudden high inflow change detection circuit for eliminating from a series of emptying characteristic calculations taken over a period of time those measurements which are outside of a predetermined acceptance range. The wet well dimensions, level detector signals, clock signals and pump status signals are supplied as inputs to both a volume rate of change calculator and to the sudden high inflow change detector. In the event of an undesirable measurement, the sudden high inflow changes detection circuit operates a gate to isolate the volume rate of change calculator from the emptying characteristic calculator that calculates outflow. A flow integrator is provided for calculating volume per cycle from the volume rate of change signal, and an inflow calculator serves to produce inflow from the volume per cycle signal.
摘要翻译： 公开了一种泵站流量计，其包括突然的高流入变化检测电路，用于消除在一段时间内进行超出预定接受范围的测量的一系列排空特性计算。 湿阱尺寸，电平检测器信号，时钟信号和泵状态信号作为输入到容量变化率计算器和突然的高流入变化检测器。 在不期望的测量的情况下，突然的高流入变化检测电路操作门，以将体积变化率计算器与计算流出的排空特征计算器隔离。 提供流量积分器，用于根据体积变化率信号计算每个循环的体积，并且流入计算器用于从每个循环信号的体积产生流入。
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