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公开(公告)号：US20110280812A1
公开(公告)日：2011-11-17
申请号：US12778622
申请日：2010-05-12
申请人： Karunananda Bombuwala , Adam Jan Janczuk , Thumplasseril V. John , Kenneth Kraut , Zhihua Liu , Neelima Mannava , Hou Wu , Ying Yang
发明人： Karunananda Bombuwala , Adam Jan Janczuk , Thumplasseril V. John , Kenneth Kraut , Zhihua Liu , Neelima Mannava , Hou Wu , Ying Yang
CPC分类号： C07C233/09 , A23L27/202 , A23L27/88
摘要： The present invention has discovered that amide compounds represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R and R′ is independently selected from the group consisting of H and C1-C10 linear, branched, or cyclic alkyl, alkenyl, alkynyl or aromactic groups. Thus, the amide compounds of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
摘要翻译： 本发明已经发现，下述式I所示的酰胺化合物具有出人意料的且有利的风味增强和改性特性：其中R和R'独立地选自H和C 1 -C 10直链，支链或环状烷基 ，烯基，炔基或芳族基团。 因此，本发明的酰胺化合物可以用于增强或改变口腔消耗性组合物如食品，口香糖，牙科和口腔卫生用品以及药用产品的风味。
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公开(公告)号：US09681678B2
公开(公告)日：2017-06-20
申请号：US13078526
申请日：2011-04-01
申请人： Kathryn Bardsley , Bryan Scott Delchamps , Zhihua Liu , Neelima Mannava , Hou Wu
发明人： Kathryn Bardsley , Bryan Scott Delchamps , Zhihua Liu , Neelima Mannava , Hou Wu
IPC分类号： A23L27/20
CPC分类号： A23L27/2052
摘要： The present invention has discovered that flavone glycosides represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R1 is selected from the group consisting of H and CH3, R2 is selected from the group consisting of H and OH, and R3 is a 7-O-glycoside. Thus, the flavone glycosides of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
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公开(公告)号：US20120251465A1
公开(公告)日：2012-10-04
申请号：US13078526
申请日：2011-04-01
申请人： Kathryn Bardsley , Bryan Scott Delchamps , Zhihua Liu , Neelima Mannava , Hou Wu
发明人： Kathryn Bardsley , Bryan Scott Delchamps , Zhihua Liu , Neelima Mannava , Hou Wu
CPC分类号： A23L27/2052
摘要： The present invention has discovered that flavone glycosides represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R1 is selected from the group consisting of H and CH3, R2 is selected from the group consisting of H and OH, and R3 is a 7-O-glycoside. Thus, the flavone glycosides of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
摘要翻译： 本发明已经发现，下面给出的式I所示的黄酮糖苷具有意想不到的和有利的风味增强和改性特性：其中R1选自H和CH3，R2选自H和OH， R3为7-O-糖苷。 因此，本发明的黄酮糖苷可用于增强或改善口服消耗品组合物如食品，口香糖，牙科和口腔卫生用品以及药用产品的风味。
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公开(公告)号：US20130011345A1
公开(公告)日：2013-01-10
申请号：US13178550
申请日：2011-07-08
申请人： Adam Jan Janczuk , Zhihua Liu
发明人： Adam Jan Janczuk , Zhihua Liu
CPC分类号： C07C233/09 , A23G4/06 , A23L27/202 , A23L27/88 , A23V2002/00 , A23V2200/00 , A61K8/42 , A61Q11/00 , A23V2200/224 , A23V2250/1868 , A23V2250/187 , A23V2250/1882 , A23V2250/5028 , A23V2250/54244
摘要： The present invention has discovered that amide compounds represented by Formula I set forth below and isomers thereof have unexpected and advantageous flavor enhancement and modification properties: The amide compounds of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
摘要翻译： 本发明已经发现，下述式I所示的酰胺化合物及其异构体具有出人意料的且有利的风味增强和改性特性：本发明的酰胺化合物可用于增强或改善口服消耗品组合物的风味，例如 作为食品，口香糖，牙科和口腔卫生用品以及医药产品。
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公开(公告)号：US20120032509A1
公开(公告)日：2012-02-09
申请号：US13272674
申请日：2011-10-13
申请人： Xiaodong Fan , Xiaming Jing , Zhihua Liu , Xujun Liu
发明人： Xiaodong Fan , Xiaming Jing , Zhihua Liu , Xujun Liu
IPC分类号： H02M3/335
CPC分类号： H02M3/33561 , H02M3/33592 , Y02B70/1475 , Y10T307/406
摘要： A voltage transforming device is provided, which includes: a first voltage transforming module, configured to perform a pre-stage voltage transformation on an input DC voltage to output an isolated DC voltage, in which the pre-stage voltage transformation includes a primary transformation that converts the input DC voltage to a to-be-transformed AC voltage, a working period of the primary transformation includes a first half period and a second half period, and a dead time exists when a first half period and a second half period are switched between each other; a capacitor filtering module, configured to perform capacitor filtering compensation on the isolated DC voltage in the dead time to output a stable intermediate DC voltage; and a second voltage transforming module, configured to perform at least two separate post-stage voltage transformations on the intermediate DC voltage to output DC voltages required by at least two loads.
摘要翻译： 提供了一种电压变换装置，其包括：第一电压变换模块，被配置为对输入DC电压执行前级电压变换以输出隔离的DC电压，其中所述前级电压变换包括主变换， 将输入直流电压转换为变换后的交流电压，一次变换的工作周期包括前半周期和后半周期，当切换前半周期和后半周期时，存在死区时间 彼此之间 电容滤波模块，被配置为在死区时间对隔离的直流电压进行电容滤波补偿，以输出稳定的中间直流电压; 以及第二电压变换模块，其被配置为对所述中间DC电压执行至少两个分离的后级电压变换，以输出至少两个负载所需的DC电压。
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6.发明申请公开(公告)号：US20110294794A1
公开(公告)日：2011-12-01
申请号：US13129360
申请日：2009-11-13
申请人： Peter T. Lansbury, JR. , Craig J. Justman , Tom N. Grammatopoulos , Berkley A. Lynch , Zhihua Liu
发明人： Peter T. Lansbury, JR. , Craig J. Justman , Tom N. Grammatopoulos , Berkley A. Lynch , Zhihua Liu
IPC分类号： A61K31/4174 , A61K31/4439 , A61K31/5513 , A61K31/4545 , A61P25/28 , A61P25/14 , A61P27/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/16 , A61K31/496 , A61P3/00
CPC分类号： A61K31/4178 , A61K31/4406 , A61K31/4704 , A61K31/4709 , A61K31/496 , A61K31/55 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant.
摘要翻译： 提供了包含可用于治疗蛋白病的低剂量法呢基转移酶抑制剂的方法和药物组合物。 这些低剂量低于这些化合物最初设计的肿瘤治疗中使用的剂量。 该治疗包括向有需要的受试者施用治疗有效量的法呢基转移酶抑制剂，其中所述量有效地抑制参与自噬途径的非Ras FTase底物的法呢基化，而基本上不影响Ras或其它的法呢基化 肿瘤相关底物。 根据本发明的治疗还可以包括乙酰胆碱酯酶抑制剂，神经营养受体的激活剂，NMDA拮抗剂，淀粉样蛋白沉积抑制剂，抗精神病药，抗抑郁药，抗焦虑剂或抗氧化剂。
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公开(公告)号：US20110241424A1
公开(公告)日：2011-10-06
申请号：US12980047
申请日：2010-12-28
申请人： Xiaodong Fan , Xiaming Jing , Zhihua Liu , Xujun Liu
发明人： Xiaodong Fan , Xiaming Jing , Zhihua Liu , Xujun Liu
CPC分类号： H02M3/33561 , H02M3/33592 , Y02B70/1475 , Y10T307/406
摘要： A voltage transforming device is provided, which includes: a first voltage transforming module, configured to perform a pre-stage voltage transformation on an input DC voltage to output an isolated DC voltage, in which the pre-stage voltage transformation includes a primary transformation that converts the input DC voltage to a to-be-transformed AC voltage; a capacitor filtering module, configured to perform capacitor filtering compensation on the isolated DC voltage in the dead time to output a stable intermediate DC voltage; and a second voltage transforming module, configured to perform at least two separate post-stage voltage transformations on the intermediate DC voltage to output DC voltages required by at least two loads. A voltage transforming method and a power supply system are also provided. Thereby, the decoupling of the pre-stage and post-stage working modes is achieved, and the interference suffered during voltage transformation is reduced.
摘要翻译： 提供了一种电压变换装置，其包括：第一电压变换模块，被配置为对输入DC电压执行前级电压变换以输出隔离的DC电压，其中所述前级电压变换包括主变换， 将输入直流电压转换为变换后的交流电压; 电容滤波模块，被配置为在死区时间对隔离的直流电压进行电容滤波补偿，以输出稳定的中间直流电压; 以及第二电压变换模块，其被配置为对所述中间DC电压执行至少两个分离的后级电压变换，以输出至少两个负载所需的DC电压。 还提供了电压变换方法和电源系统。 因此，实现了前级和后级工作模式的去耦，并且降低了电压转换期间的干扰。
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公开(公告)号：US20060106060A1
公开(公告)日：2006-05-18
申请号：US11084715
申请日：2005-03-18
申请人： Peter Lansbury , Zhihua Liu
发明人： Peter Lansbury , Zhihua Liu
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709
摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject a farnesyl transferase inhibitor compound.
摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括对突触核蛋白病患者施用法呢基转移酶抑制剂化合物。
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公开(公告)号：US20050288298A1
公开(公告)日：2005-12-29
申请号：US11084740
申请日：2005-03-18
申请人： Peter Lansbury , Zhihua Liu
发明人： Peter Lansbury , Zhihua Liu
IPC分类号： A61K31/473 , A61K31/496
CPC分类号： A61K31/473
摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject one or more farnesyl transferase inhibitor compounds.
摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括向突触核蛋白病患者施用一种或多种法呢基转移酶抑制剂化合物。
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公开(公告)号：US20050277629A1
公开(公告)日：2005-12-15
申请号：US11084695
申请日：2005-03-18
申请人： Peter Lansbury , Zhihua Liu
发明人： Peter Lansbury , Zhihua Liu
IPC分类号： A61K31/497 , A61K31/551
CPC分类号： A61K31/497 , A61K31/222 , A61K31/4174 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06
摘要： Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject one or more farnesyl transferase inhibitor compounds.
摘要翻译： 提供了治疗突触核蛋白病（例如帕金森病，弥漫性路易体病和多系统萎缩）的方法，包括向突触核蛋白病患者施用一种或多种法呢基转移酶抑制剂化合物。
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