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公开(公告)号：US08067182B2
公开(公告)日：2011-11-29
申请号：US11372054
申请日：2006-03-10
Applicant: Brian D. Kelley , James E. Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary B. Switzer , Suresh Vunnum , Tianning Yu
Inventor： Brian D. Kelley , James E. Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary B. Switzer , Suresh Vunnum , Tianning Yu
CPC classification number: B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
Abstract translation: 本发明涉及使用弱分配色谱从含有一种或多种杂质的载体流体中纯化产物的方法。 此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。
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公开(公告)号：US20120138537A1
公开(公告)日：2012-06-07
申请号：US13305045
申请日：2011-11-28
Applicant: Brian D. Kelley , James E. Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary B. Switzer , Suresh Vunnum , Tianning Yu
Inventor： Brian D. Kelley , James E. Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary B. Switzer , Suresh Vunnum , Tianning Yu
IPC: B01D15/08
CPC classification number: B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
Abstract translation: 本发明涉及使用弱分配色谱从含有一种或多种杂质的载体流体中纯化产物的方法。 此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。
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公开(公告)号：US20070060741A1
公开(公告)日：2007-03-15
申请号：US11372054
申请日：2006-03-10
Applicant: Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
Inventor： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
IPC: C07K16/00
CPC classification number: B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
Abstract translation: 本发明涉及使用弱分配色谱从含有一种或多种杂质的载体流体中纯化产物的方法。 此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。
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公开(公告)号：US20070054390A1
公开(公告)日：2007-03-08
申请号：US11510634
申请日：2006-08-28
Applicant: Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
Inventor： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
IPC: C12N9/00 , C07K16/18 , C07K14/52 , C07K14/54 , C07K14/575
CPC classification number: B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
Abstract translation: 本发明涉及使用弱分配色谱从负载流体中纯化产物的方法。 此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。
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