公开(公告)号：US06583132B1

公开(公告)日：2003-06-24

申请号：US09201722

申请日：1998-11-30

申请人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

IPC分类号： A61K31555

CPC分类号： A61K31/555 ,  A61K31/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂和细胞外水平的方法，从而进一步调节这些氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。

公开(公告)号：US07470677B2

公开(公告)日：2008-12-30

申请号：US10457071

申请日：2003-06-09

申请人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

IPC分类号： A61K31/555 ,  A61K33/34 ,  A61K33/32 ,  A61K31/28 ,  C07D487/22 ,  A01N55/02 ,  A01N59/20 ,  A01N59/16

CPC分类号： A61K31/555 ,  A61K31/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂和细胞外水平的方法，从而进一步调节这些氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。

公开(公告)号：US6127356A

公开(公告)日：2000-10-03

申请号：US663028

申请日：1996-06-07

申请人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman ,  Michael P. Trova ,  Ines Batinic-Haberle

IPC分类号： A01N55/02 ,  A61K31/409 ,  A61K31/444 ,  A61K31/555 ,  C07B47/00 ,  C07D487/22 ,  C09K15/04 ,  C09K15/32

CPC分类号： A61K31/555 ,  A61K31/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

公开(公告)号：US5994339A

公开(公告)日：1999-11-30

申请号：US476866

申请日：1995-06-07

申请人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman

发明人： James D. Crapo ,  Irwin Fridovich ,  Tim Oury ,  Brian J. Day ,  Rodney J. Folz ,  Bruce A. Freeman

IPC分类号： A61K9/127 ,  A61K38/00 ,  A61K47/48 ,  C07D487/22 ,  C07K14/81 ,  C12N9/02 ,  C12N15/85 ,  A01N55/02 ,  C07B47/00 ,  C09K15/04 ,  C09K15/32

CPC分类号： A01K67/0278 ,  A61K47/48069 ,  A61K47/48246 ,  A61K9/1272 ,  C07D487/22 ,  C07K14/8121 ,  C12N15/8509 ,  C12N9/0089 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0368 ,  A61K38/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.