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公开(公告)号：US06583132B1
公开(公告)日：2003-06-24
申请号：US09201722
申请日：1998-11-30
申请人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
发明人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
IPC分类号： A61K31555
CPC分类号： A61K31/555 , A61K31/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂和细胞外水平的方法，从而进一步调节这些氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US07470677B2
公开(公告)日：2008-12-30
申请号：US10457071
申请日：2003-06-09
申请人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
发明人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
IPC分类号： A61K31/555 , A61K33/34 , A61K33/32 , A61K31/28 , C07D487/22 , A01N55/02 , A01N59/20 , A01N59/16
CPC分类号： A61K31/555 , A61K31/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂和细胞外水平的方法，从而进一步调节这些氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US6127356A
公开(公告)日：2000-10-03
申请号：US663028
申请日：1996-06-07
申请人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
发明人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
IPC分类号： A01N55/02 , A61K31/409 , A61K31/444 , A61K31/555 , C07B47/00 , C07D487/22 , C09K15/04 , C09K15/32
CPC分类号： A61K31/555 , A61K31/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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公开(公告)号：US5994339A
公开(公告)日：1999-11-30
申请号：US476866
申请日：1995-06-07
申请人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman
发明人： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07D487/22 , C07K14/81 , C12N9/02 , C12N15/85 , A01N55/02 , C07B47/00 , C09K15/04 , C09K15/32
CPC分类号： A01K67/0278 , A61K47/48069 , A61K47/48246 , A61K9/1272 , C07D487/22 , C07K14/8121 , C12N15/8509 , C12N9/0089 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , A61K38/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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公开(公告)号：US20110065679A1
公开(公告)日：2011-03-17
申请号：US12885198
申请日：2010-09-17
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/555 , A61P11/00 , A61P29/00
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US08546562B2
公开(公告)日：2013-10-01
申请号：US13457232
申请日：2012-04-26
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： C07D487/22 , A01N55/02
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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公开(公告)号：US08217026B2
公开(公告)日：2012-07-10
申请号：US12885198
申请日：2010-09-17
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US07820644B2
公开(公告)日：2010-10-26
申请号：US11424662
申请日：2006-06-16
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US07189707B2
公开(公告)日：2007-03-13
申请号：US10349171
申请日：2003-01-23
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/409
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US20120214780A1
公开(公告)日：2012-08-23
申请号：US13457232
申请日：2012-04-26
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/555 , A61P9/10
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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