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    SLO2 and SLO4, novel potassium channel proteins from human brain
    2.
    发明申请
    SLO2 and SLO4, novel potassium channel proteins from human brain 失效
    SLO2和SLO4，来自人脑的新型钾通道蛋白

    公开(公告)号：US20060099640A1

    公开(公告)日：2006-05-11

    申请号：US11325764

    申请日：2006-01-04

    申请人： Timothy Jegla ,  Julie Witzel

    发明人： Timothy Jegla ,  Julie Witzel

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.

    摘要翻译： 本发明提供了Slo2和Slo4的分离的核酸和氨基酸序列，Slo通道蛋白家族的成员也称为“maxi”或BK钾通道蛋白。 本文还提供了对Slo2和Slo4的抗体，检测Slo2和Slo4的方法，使用生物活性的Slo2和Slo4筛选钾通道激活剂和抑制剂的方法，以及筛选活化剂和电压门控钾通道抑制剂的试剂盒 包括Slo2和Slo 4。

    CNG3B: a novel cyclic nucleotide-gated cation channel
    4.
    发明申请
    CNG3B: a novel cyclic nucleotide-gated cation channel 有权
    CNG3B：一种新型的环核苷酸门控阳离子通道

    公开(公告)号：US20080004430A1

    公开(公告)日：2008-01-03

    申请号：US11585426

    申请日：2006-10-23

    申请人： Christopher Creech ,  Timothy Jegla

    发明人： Christopher Creech ,  Timothy Jegla

    IPC分类号： C07K14/00

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.

    摘要翻译： 本发明提供分离的CNG3B的核酸和氨基酸序列，CNG3B的抗体，检测CNG3B的方法，以及使用生物活性CNG3B筛选环核苷酸门控离子通道的调节剂的方法。 本发明还在计算机系统中提供筛选人CNG3B基因突变的方法以及鉴定人CNG3B多肽的三维结构的方法。

    Human HAC3
    5.
    发明申请
    Human HAC3 审中-公开
    人类HAC3

    公开(公告)号：US20070128653A1

    公开(公告)日：2007-06-07

    申请号：US11655331

    申请日：2007-01-19

    申请人： Timothy Jegla

    发明人： Timothy Jegla

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00 ,  G01N33/48 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.

    摘要翻译： 本发明提供hHAC3的分离的核酸和氨基酸序列，hHAC3的抗体，检测hHAC3的方法，以及使用生物活性的hHAC3筛选调节剂超极化激活的阳离子通道的方法。 本发明还在计算机系统中提供筛选人HAC3基因突变的方法以及鉴定人HAC3多肽的三维结构的方法。

    KCNQ5, a novel potassium channel
    7.
    发明申请
    KCNQ5, a novel potassium channel 失效

    公开(公告)号：US20060275790A1

    公开(公告)日：2006-12-07

    申请号：US11347493

    申请日：2006-02-03

    申请人： Timothy Jegla

    发明人： Timothy Jegla

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.

    Human HAC3
    8.
    发明申请
    Human HAC3 失效

    公开(公告)号：US20060257970A1

    公开(公告)日：2006-11-16

    申请号：US09767597

    申请日：2001-01-22

    申请人： Timothy Jegla

    发明人： Timothy Jegla

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.

    BK beta subunits of Slo family potassium channels
    9.
    发明申请
    BK beta subunits of Slo family potassium channels 失效
    Slo家族钾通道的BKβ亚基

    公开(公告)号：US20060004187A1

    公开(公告)日：2006-01-05

    申请号：US11219359

    申请日：2005-09-02

    申请人： Timothy Jegla ,  Alan Wickenden ,  Yi Liu

    发明人： Timothy Jegla ,  Alan Wickenden ,  Yi Liu

    IPC分类号： C07K14/705 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.

    摘要翻译： 本发明提供了BKβ2，BKβ3和BKβ4的分离的核酸和氨基酸序列，BKβ亚基的抗体，检测BKβ亚基的方法，筛选包含BK的Slo钾通道调节剂的方法 β亚基和用于筛选包含BKβ亚基的Slo家族钾通道的激活剂和抑制剂的试剂盒。