利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.016 秒)

    Cycloalkene derivatives, process for producing the same, and use
    4.
    发明授权
    Cycloalkene derivatives, process for producing the same, and use 有权
    环烯烃衍生物，生产方法和使用

    公开(公告)号：US06495604B1

    公开(公告)日：2002-12-17

    申请号：US09622392

    申请日：2000-08-14

    申请人： Yuzo Ichimori ,  Masayuki Ii ,  Katsumi Itoh ,  Tomoyuki Kitazaki ,  Junji Yamada

    发明人： Yuzo Ichimori ,  Masayuki Ii ,  Katsumi Itoh ,  Tomoyuki Kitazaki ,  Junji Yamada

    IPC分类号： A61K3118

    CPC分类号： C07D249/08 ,  C07C311/14 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2601/18 ,  C07D249/06 ,  C07D257/04 ,  C07D275/06

    摘要： The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group represented by the formula: OR1 (wherein R1 represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents) or a group represented by the formula: wherein R1b represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R1c is, same with or different from R1b, a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R0 represents a hydrogen atom or an aliphatic hydrocarbon group, or R and R0 represents a bond with each other, Ar represents an aromatic hydrocarbon group optionally having substituents, and n is an integer of 1 to 4, or a salt thereof, which is a agent for preventing or treating diseases such as cardiac disease, autoimmune disease, septick shock, etc.

    摘要翻译： 本发明提供由下式表示的化合物：其中R表示任选具有取代基的脂族烃基，任选具有取代基的芳族烃基，任选具有取代基的杂环基，由式OR1表示的基团（其中R1表示 氢原子或任选具有取代基的脂族烃基）或由下式表示的基团：其中R 1b表示氢原子或任选具有取代基的脂族烃基，R 1c与R 1b相同或不同，为氢原子或脂族 任选具有取代基的烃基，R 0表示氢原子或脂族烃基，或R和R 0表示彼此的键，Ar表示任选具有取代基的芳香族烃基，n表示1〜4的整数，或者 其盐，其是用于预防或治疗诸如心脏病的疾病的药剂 麻疹，败血性休克等

    Azole compounds, their production and their use
    5.
    发明授权
    Azole compounds, their production and their use 失效
    唑类化合物，其生产及其用途

    公开(公告)号：US06407129B1

    公开(公告)日：2002-06-18

    申请号：US09381479

    申请日：1999-09-20

    申请人： Katsumi Itoh ,  Tomoyuki Kitazaki ,  Kenji Okonogi

    发明人： Katsumi Itoh ,  Tomoyuki Kitazaki ,  Kenji Okonogi

    IPC分类号： A61K3141

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of the nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated in vivo and the substituent can be eliminated in vivo to be converted into an antifungal azole compound, has an improved solubility in water, can advantageously be applied to injection, has an improved internal absorption and can be expected to have a good effect for the treatment or prevention of disease.

    摘要翻译： 构成唑环的氮原子之一的季铵化的含氮咪唑-1-基或1,2,4-三唑-1-基化合物被能够在体内消除的取代基季铵化，并且可以消除取代基 在体内被转化为抗真菌唑化合物，在水中的溶解度提高，可有利地应用于注射，具有改善的内部吸收，并且可以预期对于治疗或预防疾病具有良好的效果。