公开(公告)号：US20180224463A1

公开(公告)日：2018-08-09

申请号：US15883126

申请日：2018-01-30

申请人： Niklas Thomas BAERLECKEN ,  Torsten WITTE

发明人： Niklas Thomas BAERLECKEN ,  Torsten WITTE

IPC分类号： G01N33/68 ,  A61K38/45 ,  C12Q1/48 ,  G01N33/564

CPC分类号： G01N33/6854 ,  A61K38/45 ,  C12Q1/485 ,  C12Y207/1101 ,  G01N33/564 ,  G01N2333/70596 ,  G01N2800/102 ,  G01N2800/105 ,  G01N2800/50

摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diaposis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, it a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnostic of Spa, in particular, AS and undifferentiated spondyloarthritis.

公开(公告)号：US09915667B2

公开(公告)日：2018-03-13

申请号：US13981956

申请日：2012-01-27

申请人： Torsten Witte ,  Niklas Thomas Baerlecken

发明人： Torsten Witte ,  Niklas Thomas Baerlecken

IPC分类号： G01N33/564 ,  G01N33/68 ,  A61K39/00 ,  C07K16/44

CPC分类号： G01N33/6893 ,  A61K39/0008 ,  C07K16/44 ,  G01N33/564 ,  G01N2800/101 ,  G01N2800/328 ,  G01N2800/50 ,  G01N2800/52

摘要： Provided herein are methods for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR), and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. In addition, test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject are also provided.

公开(公告)号：US09915664B2

公开(公告)日：2018-03-13

申请号：US13816962

申请日：2011-08-16

申请人： Niklas Thomas Baerlecken ,  Torsten Witte

发明人： Niklas Thomas Baerlecken ,  Torsten Witte

IPC分类号： G01N33/68 ,  C12Q1/48 ,  G01N33/564 ,  A61K38/45

CPC分类号： G01N33/6854 ,  A61K38/45 ,  C12Q1/485 ,  C12Y207/1101 ,  G01N33/564 ,  G01N2333/70596 ,  G01N2800/102 ,  G01N2800/105 ,  G01N2800/50

摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

公开(公告)号：US20130203088A1

公开(公告)日：2013-08-08

申请号：US13816962

申请日：2011-08-16

申请人： Niklas Thomas Baerlecken ,  Torsten Witte

发明人： Niklas Thomas Baerlecken ,  Torsten Witte

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  A61K38/45 ,  C12Q1/485 ,  C12Y207/1101 ,  G01N33/564 ,  G01N2333/70596 ,  G01N2800/102 ,  G01N2800/105 ,  G01N2800/50

摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

摘要翻译： 本发明一般涉及用于诊断受试者，特别是哺乳动物的脊柱关节炎（Spa），特别是强直性脊柱炎（AS）和未分化脊椎关节炎的发展的存在或风险或治疗控制的方法。 此外，本发明涉及用于诊断受试者中存在或发展风险的治疗试剂盒，或用于SPA的治疗控制，如AS和未分化的脊椎关节炎。 特别地，本发明涉及一种用于分析在针对CD74和/或IKBKB的自身抗体存在的受试者中用于诊断发展的存在或风险或用于SPA的治疗控制（如AS和未分化脊柱关节炎）的方法 课程。 针对CD74和/或IKBKB的自身抗体的存在表明存在或发展的风险，或用于SPA的治疗控制，如AS和未分化的脊柱关节炎。 特别地，检测针对CD74和/或IKBKB的自身抗体的存在允许Spa的早期诊断，特别是AS和未分化的脊柱关节炎。

公开(公告)号：US20090325187A1

公开(公告)日：2009-12-31

申请号：US11662919

申请日：2004-09-15

申请人： Torsten Witte ,  Torsten Matthias

发明人： Torsten Witte ,  Torsten Matthias

IPC分类号： G01N33/53 ,  C07K14/00 ,  C07K16/18

CPC分类号： C07K14/70503 ,  C07K2319/21

摘要： Medical use of ILT6 for modulating the immune response, as well as to pharmaceutical compositions containing ILT6.In a further aspect, the present invention relates to the medical treatment of human beings using ILT6 to modulate their immune response, for example directed against heterologous and/or autologous antigens. Furthermore, the present invention relates to the analysis using ILT6 for diagnostic purposes and to diagnostic compositions that can be employed for that analysis.

摘要翻译： 医学使用ILT6调节免疫应答，以及含有ILT6的药物组合物。 在另一方面，本发明涉及使用ILT6调节其免疫应答的人的医学治疗，例如针对异源和/或自体抗原。 此外，本发明涉及用于诊断目的的使用ILT6的分析和可用于该分析的诊断组合物。

公开(公告)号：US20080092960A1

公开(公告)日：2008-04-24

申请号：US11875070

申请日：2007-10-19

申请人： Peter Manecke ,  Harald Hahn ,  Peter Graf ,  Rainer Imhof ,  Torsten Witte

发明人： Peter Manecke ,  Harald Hahn ,  Peter Graf ,  Rainer Imhof ,  Torsten Witte

IPC分类号： F16K37/00

CPC分类号： F16K37/0033 ,  F16K37/0041 ,  Y10T137/8242

摘要： A valve system has a valve housing, in which at least one valve element is displaceably guided. At least one magnetic field sensor is provided to detect the position of the valve element, which is acted upon by the magnetic field of at least one permanent magnet located on the movable valve element. The permanent magnet is guided relative to the magnetic field sensor such that it is non-rotatable but axially displaceable in the valve housing.

摘要翻译： 阀系统具有阀壳体，其中至少一个阀元件可移动地被引导。 提供至少一个磁场传感器以检测阀元件的位置，其由位于可移动阀元件上的至少一个永磁体的磁场作用。 永磁体相对于磁场传感器被引导，使得其不可旋转，但在阀壳体中可轴向移动。

公开(公告)号：US11199549B2

公开(公告)日：2021-12-14

申请号：US15883126

申请日：2018-01-30

申请人： Niklas Thomas Baerlecken ,  Torsten Witte

发明人： Niklas Thomas Baerlecken ,  Torsten Witte

IPC分类号： G01N33/564 ,  G01N33/68 ,  C12Q1/48 ,  A61K38/45

摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diaposis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, it a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnostic of Spa, in particular, AS and undifferentiated spondyloarthritis.

公开(公告)号：US08648680B2

公开(公告)日：2014-02-11

申请号：US13126985

申请日：2009-10-30

申请人： Bernhard Adler ,  Steffen Loritz ,  Matthias Stitz ,  Torsten Witte ,  Ralf Bosch

发明人： Bernhard Adler ,  Steffen Loritz ,  Matthias Stitz ,  Torsten Witte ,  Ralf Bosch

IPC分类号： H01F7/00 ,  H01F7/08 ,  H01F3/00

CPC分类号： H01F7/1607 ,  F16K31/0675 ,  H01F7/126 ,  H01F7/127 ,  H01F2007/163

摘要： An electromagnet having a pole tube, and having a coil that encompasses the pole tube and is mounted so as to be displaceable along a longitudinal axis of the pole tube, a first end face of the coil or of the housing thereof bearing on a first counter-bearing disposed at a first end portion of the pole tube, and an elastic element, which is supported on a second counter-bearing and biases the coil and/or the housing thereof against the first counter-bearing, is provided between a second end face of the coil or the housing thereof and the second counter-bearing disposed at a second end portion of the pole tube.

摘要翻译： 一种具有极管的电磁体，具有包围所述极管并被安装成沿着所述极管的纵向轴线移位的线圈，所述线圈或其壳体的第一端面承载在第一计数器 - 设置在所述极管的第一端部处，并且弹性元件设置在第二端部之间，所述弹性元件被支撑在第二反向轴承上并且将所述线圈和/或所述壳体抵靠所述第一反向轴承偏置 线圈或其壳体的表面，以及设置在极管的第二端部处的第二反向轴承。

公开(公告)号：US20130310273A1

公开(公告)日：2013-11-21

申请号：US13981956

申请日：2012-01-27

申请人： Torsten Witte ,  Niklas Thomas Baerlecken

发明人： Torsten Witte ,  Niklas Thomas Baerlecken

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  A61K39/0008 ,  C07K16/44 ,  G01N33/564 ,  G01N2800/101 ,  G01N2800/328 ,  G01N2800/50 ,  G01N2800/52

摘要： The present inventions relates generally to methods for diagnosing the presence or the risk of development or the therapy control of vasculitis, in particular, of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR) and Takayasu's arteritis in a subject, in particular, in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. The presence of antibodies against ferritin or immunoreactive peptides thereof is indicative for the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis. In particular, detection of the presence of antibodies against ferritin or immunoreactive peptides thereof, allows early diagnosis of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis.

摘要翻译： 本发明一般涉及用于诊断血管炎的存在或风险或治疗控制的方法，特别是大血管血管炎，如巨细胞动脉炎（GCA），风湿综合征（PMR）和Takayasu的动脉炎 主题，特别是哺乳动物。 此外，本发明涉及用于诊断存在或发展风险的检测试剂盒，或用于在受试者中诊断血管炎，特别是大血管血管炎（如GCA，PMR和Takayasu的动脉炎）的治疗控制 。 特别地，本发明涉及用于诊断存在或风险的方法，或用于治疗血管炎，特别是大血管血管炎，如GCA，PMR和Takayasu的动脉炎的治疗控制方法， 抗体，特别是重链铁蛋白或其免疫反应性肽或铁蛋白类似蛋白，优选细菌铁蛋白类似物蛋白或其免疫反应性肽。 针对铁蛋白或其免疫反应性肽的抗体的存在指示存在或发展的风险，或用于治疗血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的治疗控制。 特别地，检测抗铁蛋白或其免疫反应性肽的抗体的存在允许血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的早期诊断。

公开(公告)号：US20120025938A1

公开(公告)日：2012-02-02

申请号：US13126985

申请日：2009-10-30

申请人： Bernhard Adler ,  Steffen Loritz ,  Matthias Stitz ,  Torsten Witte ,  Ralf Bosch

发明人： Bernhard Adler ,  Steffen Loritz ,  Matthias Stitz ,  Torsten Witte ,  Ralf Bosch

IPC分类号： H01F7/06

CPC分类号： H01F7/1607 ,  F16K31/0675 ,  H01F7/126 ,  H01F7/127 ,  H01F2007/163

摘要： An electromagnet having a pole tube, and having a coil that encompasses the pole tube and is mounted so as to be displaceable along a longitudinal axis of the pole tube, a first end face of the coil or of the housing thereof bearing on a first counter-bearing disposed at a first end portion of the pole tube, and an elastic element, which is supported on a second counter-bearing and biases the coil and/or the housing thereof against the first counter-bearing, is provided between a second end face of the coil or the housing thereof and the second counter-bearing disposed at a second end portion of the pole tube.

摘要翻译： 一种具有极管的电磁体，具有包围所述极管并被安装成沿着所述极管的纵向轴线移位的线圈，所述线圈或其壳体的第一端面承载在第一计数器 - 设置在所述极管的第一端部处，并且弹性元件设置在第二端部之间，所述弹性元件被支撑在第二反向轴承上并且将所述线圈和/或所述壳体抵靠所述第一反向轴承偏置 线圈或其壳体的表面，以及设置在极管的第二端部处的第二反向轴承。