公开(公告)号：US20090187025A1

公开(公告)日：2009-07-23

申请号：US10587045

申请日：2005-01-26

申请人： Ayako Hashimoto ,  Takashi Imaizumi ,  Goro Miyakoda ,  Toyoki Mori

发明人： Ayako Hashimoto ,  Takashi Imaizumi ,  Goro Miyakoda ,  Toyoki Mori

IPC分类号： C07D211/34

CPC分类号： A61K31/4468

摘要： The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).

摘要翻译： 本发明提供一种用于促进血管生成的药物组合物，即使在不影响微循环的血管培养系统中也具有血管生成促进作用。 用于促进本发明的血管发生的药物组合物包含至少一种选自由通式（1）表示的哌啶化合物或其盐的化合物：其中R表示可以具有作为取代基的苯甲酰基 苯基环，可以具有低级烷酰基的氨基和低级烷基中的1〜3个基团; R 1表示氢原子或低级烷基; R 2表示苯基低级烷基 组）。

公开(公告)号：US20070105911A1

公开(公告)日：2007-05-10

申请号：US11637125

申请日：2006-12-12

申请人： Masatoshi Chihiro ,  Takayuki Matsuzani ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Jurimura ,  Fujio Tabusa

发明人： Masatoshi Chihiro ,  Takayuki Matsuzani ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Jurimura ,  Fujio Tabusa

IPC分类号： A61K31/4439 ,  A61K31/426

CPC分类号： A61K31/506 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  Y10S977/904

摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: (wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

摘要翻译： 本发明提供抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自由以下通式表示的噻唑衍生物的化合物：（其中R 1是苯基， 可以在苯环上具有作为取代基的低级烷氧基，R 2是由以下通式表示的基团：（其中R 3 O / 可以相同或不同，分别为羧基，低级烷氧基等）和其盐。

公开(公告)号：US6096736A

公开(公告)日：2000-08-01

申请号：US91295

申请日：1998-06-12

申请人： Hidenori Ogawa ,  Kazumi Kondo ,  Tomoichi Shinohara ,  Keizo Kan ,  Yoshihisa Tanada ,  Muneaki Kurimura ,  Seiji Morita ,  Minoru Uchida ,  Toyoki Mori ,  Michiaki Tominaga ,  Yoichi Yabuuchi

发明人： Hidenori Ogawa ,  Kazumi Kondo ,  Tomoichi Shinohara ,  Keizo Kan ,  Yoshihisa Tanada ,  Muneaki Kurimura ,  Seiji Morita ,  Minoru Uchida ,  Toyoki Mori ,  Michiaki Tominaga ,  Yoichi Yabuuchi

IPC分类号： C07D223/16 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D521/00 ,  A61K31/55

CPC分类号： C07D223/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： Novel benzazepine derivative of the formula [1]: ##STR1## wherein R.sup.1 is H or halogen, A is lower alkylene, R.sup.2 and R.sup.3 are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R.sup.2 and R.sup.3 may combine together with the nitrogen to which they bond to form a 5- to 7-membered saturated heterocyclic group which may optionally be substituted by a lower alkyl, etc., R.sup.4 is H, lower alkyl, OH, etc., R.sup.5 is --NHR.sup.6 (R.sup.6 is lower alkyl) or pyrrolidinyl, or a salt thereof, which show excellent anti-vasopressin activity, oxytocin antagonistic activity and vasopressin agonistic activity, and are useful as a vasopressin antagonist, a vasopressin agonist and an oxytocin antagonist.

摘要翻译： PCT No.PCT / JP96 / 03652 Sec。 371日期：1998年6月12日 102（e）1998年6月12日PCT PCT 1996年12月13日PCT公布。 公开号WO97 / 22591 日期：1997年6月26日通式[1]的新型苯并氮杂衍生物：其中R1为H或卤素，A为低级亚烷基，R2和R3相同或不同，每个H，低级烷氧基，任选具有低级烷氧基取代基的低级烷基 等等，或者R 2和R 3可以与它们键合的氮一起结合形成可任选地被低级烷基等取代的5-至7-元饱和杂环基，R 4是H，低级烷基， OH等，R5是表现出优异的抗血管加压素活性，催产素拮抗活性和加压素激动活性的-NHR6（R6是低级烷基）或吡咯烷基或其盐，并且可用作加压素拮抗剂，加压素激动剂 和催产素拮抗剂。

公开(公告)号：US20150104811A1

公开(公告)日：2015-04-16

申请号：US14238050

申请日：2012-08-10

申请人： Sei Sasaki ,  Yasukazu Ohmoto ,  Toyoki Mori ,  Fusako Iwata ,  Masahiro Muraguchi

发明人： Sei Sasaki ,  Yasukazu Ohmoto ,  Toyoki Mori ,  Fusako Iwata ,  Masahiro Muraguchi

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/5306 ,  G01N1/42 ,  G01N33/6872

摘要： The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than −80° C., in particular at −70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant.

摘要翻译： 本发明提供了在生物样品中包含的蛋白质的免疫测定中预处理生物样品的方法。 该方法包括以下步骤：（1）在高于-80℃，特别是-70℃或更高的温度下冷冻生物样品; （2）解冻冷冻生物样品; 和（3）使用表面活性剂增溶生物样品。

公开(公告)号：US20080221084A1

公开(公告)日：2008-09-11

申请号：US11927153

申请日：2007-10-29

申请人： Yongge LIU ,  Junichi KAMBAYASHI ,  Hiroyuki FUJIKI ,  Toyoki MORI

发明人： Yongge LIU ,  Junichi KAMBAYASHI ,  Hiroyuki FUJIKI ,  Toyoki MORI

IPC分类号： A61K31/55 ,  A61K31/551 ,  A61P9/04

CPC分类号： A61K31/55 ,  A61K31/551

摘要： The present invention relates to a method for reducing infarction comprising administering to a patient ion need thereof a therapeutically effective amount of a composition comprising as an active ingredient a vasopressin antagonist compound and to a composition useful therefor. The present invention also relates to a method for reducing infarction comprising administering to a patient in need thereof a therapeutically effective amount of a combination of a vasopressin antagonist compound and a beta-blocker and to combinations useful therefor. The methods, compositions and combinations of the present invention can be used for reducing infarction in the heart (myocardial infarction) and the brain (stroke). The methods, compositions and combinations of the present invention can also be used for the treatment and/or prevention of hypertension, edema, ascites, heart failure, renal function disorder, vasopressin inappropriate secretion syndrome (SIADH), hepatocirrhosis, hyponatremia, hypokalemia, polycystic kidney disease, diabetes, or circulation disorder.

摘要翻译： 本发明涉及一种减少梗塞的方法，包括向患者施用离子需要量的治疗有效量的组合物，其包含作为活性成分的加压素拮抗剂化合物和用于其的组合物。 本发明还涉及一种减少梗塞的方法，其包括对有需要的患者施用治疗有效量的加压素拮抗剂化合物和β-阻断剂的组合以及对其有用的组合。 本发明的方法，组合物和组合可用于减少心脏（心肌梗死）和脑（中风）中的梗死。 本发明的方法，组合物和组合也可用于治疗和/或预防高血压，水肿，腹水，心力衰竭，肾功能障碍，加压素不适分泌综合征（SIADH），肝硬化，低钠血症，低钾血症，多囊性 肾脏疾病，糖尿病或循环障碍。

公开(公告)号：US20110281284A1

公开(公告)日：2011-11-17

申请号：US12673346

申请日：2008-08-07

申请人： Hideji Nakamura ,  Youichi Yabuuchi ,  Yasukazu Ohmoto ,  Toyoki Mori ,  Masahiro Muraguchi ,  Keiko Oga ,  Fusako Iwata ,  Kaori Murata

发明人： Hideji Nakamura ,  Youichi Yabuuchi ,  Yasukazu Ohmoto ,  Toyoki Mori ,  Masahiro Muraguchi ,  Keiko Oga ,  Fusako Iwata ,  Kaori Murata

IPC分类号： G01N33/566 ,  C07K16/22 ,  C07K14/475

CPC分类号： G01N33/57438 ,  C07K14/4748 ,  C07K16/22 ,  C07K2317/56

摘要： According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.

摘要翻译： 根据本发明，测量慢性肝病患者血液中的HDGF，以诊断患者是否患有肝癌。 还提供了用于诊断的测量套件。

公开(公告)号：US20070238758A1

公开(公告)日：2007-10-11

申请号：US11798729

申请日：2007-05-16

申请人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

发明人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

IPC分类号： A61K31/4439 ,  A61K31/4427 ,  A61P43/00 ,  A61K31/4436

CPC分类号： A61K31/506 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  Y10S977/904

摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

摘要翻译： 本发明提供了抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自由以下通式表示的噻唑衍生物的化合物：其中R 1是苯基， 可以在苯环上具有作为取代基的低级烷氧基，R 2是由以下通式表示的基团：（其中R 3 O / 可以相同或不同，分别为羧基，低级烷氧基等）和其盐。

公开(公告)号：US06583163B2

公开(公告)日：2003-06-24

申请号：US09887143

申请日：2001-06-25

申请人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

发明人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

IPC分类号： A61K31381

CPC分类号： A61K31/506 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  Y10S977/904

摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

摘要翻译： 本发明提供抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自下列通式表示的噻唑衍生物的化合物：其中R 1为可具有低级烷氧基的苯基（s ）作为苯环上的取代基，R2是由以下通式表示的基团：（其中R3可以相同或不同，分别为羧基，低级烷氧基等） 或类似物]及其盐。

公开(公告)号：US08445516B2

公开(公告)日：2013-05-21

申请号：US10587045

申请日：2005-01-26

申请人： Ayako Hashimoto ,  Takashi Imaizumi ,  Goro Miyakoda ,  Toyoki Mori

发明人： Ayako Hashimoto ,  Takashi Imaizumi ,  Goro Miyakoda ,  Toyoki Mori

IPC分类号： A61K31/4468

CPC分类号： A61K31/4468

摘要： The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).

公开(公告)号：US08354439B2

公开(公告)日：2013-01-15

申请号：US11637125

申请日：2006-12-12

申请人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

发明人： Masatoshi Chihiro ,  Takayuki Matsuzaki ,  Hisashi Nagamoto ,  Goro Miyakoda ,  Shinobu Sueyoshi ,  Toyoki Mori ,  Kazuyoshi Kitano ,  Isao Takemura ,  Hiroshi Yamashita ,  Muneaki Kurimura ,  Fujio Tabusa

IPC分类号： A01N43/78 ,  A61K31/425 ,  C07D277/20

CPC分类号： A61K31/506 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  Y10S977/904

摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.