公开(公告)号：US20090237067A1

公开(公告)日：2009-09-24

申请号：US12050894

申请日：2008-03-18

申请人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

发明人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

IPC分类号： G01N27/00 ,  C12Q1/70

CPC分类号： G01N22/00

摘要： The present invention discloses microwave resonant absorption (MRA) of viruses through dipolar coupling to viral confined acoustic modes. The unique geometrical and mechanical properties of viruses can be reflected by the MRA frequencies, MRA linewidth, and the absorption selection rules of high-order acoustic modes. Combined these spectral characteristics with the mature microwave technology, this invention provides a novel physical mechanism to develop non-affinity-based rapid detection and identification of viruses. It can be applied in preliminary characterization on unknown or mutant viruses.

摘要翻译： 本发明公开了通过偶极耦合到病毒封闭声学模式的病毒的微波共振吸收（MRA）。 病毒的独特几何和机械性质可以通过MRA频率，MRA线宽和高阶声学模式的吸收选择规则来反映。 将这些光谱特征与成熟的微波技术结合起来，本发明提供了开发基于非亲和性的快速检测和鉴定病毒的新型物理机制。 它可以应用于未知或突变病毒的初步表征。

公开(公告)号：US08524445B2

公开(公告)日：2013-09-03

申请号：US12050894

申请日：2008-03-18

申请人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

发明人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

IPC分类号： C12Q1/70 ,  G01N27/00

CPC分类号： G01N22/00

摘要： The present invention discloses microwave resonant absorption (MRA) of viruses through dipolar coupling to viral confined acoustic modes. The unique geometrical and mechanical properties of viruses can be reflected by the MRA frequencies, MRA linewidth, and the absorption selection rules of high-order acoustic modes. Combined these spectral characteristics with the mature microwave technology, this invention provides a novel physical mechanism to develop non-affinity-based rapid detection and identification of viruses. It can be applied in preliminary characterization on unknown or mutant viruses.

摘要翻译： 本发明公开了通过偶极耦合到病毒封闭声学模式的病毒的微波共振吸收（MRA）。 病毒的独特几何和机械性质可以通过MRA频率，MRA线宽和高阶声学模式的吸收选择规则来反映。 将这些光谱特征与成熟的微波技术结合起来，本发明提供了开发基于非亲和性的快速检测和鉴定病毒的新型物理机制。 它可以应用于未知或突变病毒的初步表征。

公开(公告)号：US20110070624A1

公开(公告)日：2011-03-24

申请号：US12562591

申请日：2009-09-18

申请人： Chi-Kuang Sun ,  Tzu-Ming Liu

发明人： Chi-Kuang Sun ,  Tzu-Ming Liu

IPC分类号： C12N7/04 ,  C12M1/00

CPC分类号： C12N7/00 ,  C12N2770/32361

摘要： Virus inactivation is performed with a specific microwave frequency to induce a collective vibration of virus through microwave resonant absorption (MRA).

摘要翻译： 用特定的微波频率进行病毒灭活，以通过微波谐振吸收（MRA）诱导病毒的集体振动。

公开(公告)号：US06734976B2

公开(公告)日：2004-05-11

申请号：US10096682

申请日：2002-03-14

申请人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Yin-Chieh Huang ,  Gia-Wei Chern

发明人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Yin-Chieh Huang ,  Gia-Wei Chern

IPC分类号： G01B902

CPC分类号： G01J11/00

摘要： A method for measuring an ultrashort optical pulse, in which third order autocorrelation of femtosecond (10−15 second) optical pulses was realized based on third-harmonic-generation (THG). A THG signal with three fundamental frequency photon contributed from three different split pulses of the ultrashort optical pulse is first generated. The three split pulses have time delays &tgr;1 and &tgr;2 in between. Then, the intensity of the THG signal is detected while varying the time delays &tgr;1 and &tgr;2 between the split pulses to obtain a triple correlation of the ultrashort optical pulse. The triple correlation and its Fourier transform are used to obtain the magnitude |Ĩ(&ngr;)| and the phase &agr;(&ngr;) of the ultrashort optical pulse intensity in the frequency domain, and the intensity of the ultrashort optical pulse in the time domain I(t) is determined using the magnitude |Ĩ(&ngr;)| and the phase &agr;(&ngr;) by inverse Fourier Transform.

摘要翻译： 一种用于测量超短光脉冲的方法，其中基于三次谐波发生（THG）实现飞秒（10-15秒）光脉冲的三阶自相关。 首先产生由超短光脉冲的三个不同分离脉冲贡献的具有三个基频光子的THG信号。 三个分离脉冲之间具有时间延迟τ1和τ2。 然后，检测THG信号的强度，同时改变分离脉冲之间的时间延迟τ1和τ2，以获得超短光脉冲的三重相关。 三次相关及其傅里叶变换用于获得幅度| I（nu）| 并且在频域中的超短光脉冲强度的相位α（nu）和时域I（t）中的超短光脉冲的强度使用幅度| I（nu）| 和相位α（nu）。