公开(公告)号：US20140033821A1

公开(公告)日：2014-02-06

申请号：US13563467

申请日：2012-07-31

申请人： Chi-Kuang Sun ,  Chien-Cheng Chen ,  Yu-Chieh Wen

发明人： Chi-Kuang Sun ,  Chien-Cheng Chen ,  Yu-Chieh Wen

IPC分类号： G01N29/24 ,  B82Y15/00

CPC分类号： G01N29/4436 ,  B82Y15/00 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/46 ,  G01N2291/015 ,  G01N2291/022 ,  G01N2291/023 ,  G01N2291/0237 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/042

摘要： The present disclosure provides solutions to probing an interface. With a noninvasive measuring device provided in one embodiment of the disclosure, an acoustic wave whose frequency is higher than approximately 300 GHz is generated to propagate in a buffering film. With measuring the reflection from the interface of an object to be measured interfacing with the buffering film, it is possible in one embodiment of the disclosure that at least one physical property of the interface may be analyzed, preferably with approximately 0.3 nm resolution.

摘要翻译： 本公开提供了探测接口的解决方案。 利用在本公开的一个实施例中提供的非侵入式测量装置，产生频率高于约300GHz的声波，以在缓冲膜中传播。 通过测量与缓冲膜接口的待测量物体的界面的反射，在本公开的一个实施方案中，可以分析界面的至少一个物理性质，优选以约0.3nm的分辨率进行分析。

公开(公告)号：US08524445B2

公开(公告)日：2013-09-03

申请号：US12050894

申请日：2008-03-18

申请人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

发明人： Chi-Kuang Sun ,  Tzu-Ming Liu ,  Hung-Pin Chen

IPC分类号： C12Q1/70 ,  G01N27/00

CPC分类号： G01N22/00

摘要： The present invention discloses microwave resonant absorption (MRA) of viruses through dipolar coupling to viral confined acoustic modes. The unique geometrical and mechanical properties of viruses can be reflected by the MRA frequencies, MRA linewidth, and the absorption selection rules of high-order acoustic modes. Combined these spectral characteristics with the mature microwave technology, this invention provides a novel physical mechanism to develop non-affinity-based rapid detection and identification of viruses. It can be applied in preliminary characterization on unknown or mutant viruses.

摘要翻译： 本发明公开了通过偶极耦合到病毒封闭声学模式的病毒的微波共振吸收（MRA）。 病毒的独特几何和机械性质可以通过MRA频率，MRA线宽和高阶声学模式的吸收选择规则来反映。 将这些光谱特征与成熟的微波技术结合起来，本发明提供了开发基于非亲和性的快速检测和鉴定病毒的新型物理机制。 它可以应用于未知或突变病毒的初步表征。

公开(公告)号：US20120150042A1

公开(公告)日：2012-06-14

申请号：US12966218

申请日：2010-12-13

申请人： Chi-Kuang Sun ,  Szu-Yu Chen

发明人： Chi-Kuang Sun ,  Szu-Yu Chen

IPC分类号： A61B6/08

CPC分类号： A61B5/6834 ,  A61B5/0059 ,  A61B5/6882

摘要： This invention relates to a vacuum-pump sucker for high-resolution microscopy comprising a sucker body and a transparent plate. The vacuum-pump sucker is designed as a stabilizer for sample stabilization in a clinical optical virtual biopsy system with sub-micron resolution. The sucker is connected with a vacuum pump. As the vacuum pump pumps out air or gas, tissues around the imaged area will be sucked by the sucker and the distance between objective lens and the imaged tissue can be stabilized. In this way, the stability and resolution of the clinical biopsy system can be greatly improved.

摘要翻译： 本发明涉及一种用于高分辨率显微镜的真空泵吸盘，其包括吸盘体和透明板。 真空泵吸盘被设计为具有亚微米分辨率的临床光学虚拟活检系统中用于样品稳定的稳定剂。 吸盘与真空泵连接。 当真空泵泵出空气或气体时，成像区域周围的组织将被吸盘吸入，物镜和成像组织之间的距离可以稳定。 这样可以大大提高临床活检系统的稳定性和分辨率。

公开(公告)号：US20080025680A1

公开(公告)日：2008-01-31

申请号：US11493766

申请日：2006-07-27

申请人： Chi-Kuang Sun ,  Li-Jin Chen ,  Hung-Wen Chen

发明人： Chi-Kuang Sun ,  Li-Jin Chen ,  Hung-Wen Chen

IPC分类号： G02B6/032 ,  G02B6/02 ,  G02B6/00

CPC分类号： G02B6/02033 ,  G02B6/102 ,  H01P3/16

摘要： The invention discloses a plastic waveguide for guiding terahertz (THz) wave with a wavelength ranging from 30 to 3000 μm. The plastic waveguide includes a core and a cladding layer. At least part of the core is made of a first plastic medium having a first refractive index, and the maximum length of a cross-section of the core is smaller than the wavelength of the guided terahertz wave. The cladding layer surrounds the core and has a second refractive index lower than the first refractive index. In the invention, only one wave mode is propagated in the plastic waveguide, and a first attenuation constant of the core for the guided terahertz wave is higher than a second attenuation constant of the cladding layer for the guided terahertz wave.

摘要翻译： 本发明公开了一种用于引导波长为30〜3000μm的太赫兹（THz）波的塑料波导。 塑料波导包括芯和包层。 芯的至少一部分由具有第一折射率的第一塑料介质制成，并且芯的横截面的最大长度小于被引导的太赫兹波的波长。 包覆层围绕芯并且具有低于第一折射率的第二折射率。 在本发明中，在塑料波导中仅传播一种波模，并且用于引导太赫兹波的芯的第一衰减常数高于用于引导太赫兹波的包层的第二衰减常数。

公开(公告)号：US09795340B2

公开(公告)日：2017-10-24

申请号：US12966218

申请日：2010-12-13

申请人： Chi-Kuang Sun ,  Szu-Yu Chen

发明人： Chi-Kuang Sun ,  Szu-Yu Chen

IPC分类号： A61B5/00

CPC分类号： A61B5/6834 ,  A61B5/0059 ,  A61B5/6882

摘要： This invention relates to a vacuum-pump sucker for high-resolution microscopy comprising a sucker body and a transparent plate. The vacuum-pump sucker is designed as a stabilizer for sample stabilization in a clinical optical virtual biopsy system with sub-micron resolution. The sucker is connected with a vacuum pump. As the vacuum pump pumps out air or gas, tissues around the imaged area will be sucked by the sucker and the distance between objective lens and the imaged tissue can be stabilized. In this way, the stability and resolution of the clinical biopsy system can be greatly improved.

公开(公告)号：US20100135626A1

公开(公告)日：2010-06-03

申请号：US12536072

申请日：2009-08-05

申请人： Chi-Kuang Sun ,  Hung-Chun Chang ,  Chih-Hsien Lai ,  Yu-Chun Hsueh

发明人： Chi-Kuang Sun ,  Hung-Chun Chang ,  Chih-Hsien Lai ,  Yu-Chun Hsueh

IPC分类号： G02B6/02

CPC分类号： H01P3/16

摘要： A waveguide for guiding terahertz waves with wavelength ranging 0.1 mm-3 mm, includes a cladding tube made of a metal-free dielectric material, and a core filling a transmission space defined by the cladding tube. The core has a minimum width or diameter larger than the wavelength of the terahertz wave guided by the waveguide. The thickness of the cladding tube is smaller than the radius or one half of the width of the core. The core has an attenuation constant for the terahertz waves lower than that of the cladding tube. The waveguide guides terahertz waves mainly inside the core, and has a simple construction.

摘要翻译： 用于引导波长为0.1mm-3mm的太赫兹波的波导包括由无金属介电材料制成的包覆管，以及填充由包层管限定的透射空间的芯。 芯的最小宽度或直径大于由波导引导的太赫波的波长。 包层管的厚度小于芯的宽度的半径或一半。 核心具有比包层管低的太赫兹波的衰减常数。 波导主要在核心内引导太赫兹波，结构简单。

公开(公告)号：US06922279B2

公开(公告)日：2005-07-26

申请号：US10665443

申请日：2003-09-20

申请人： Chi-Kuang Sun ,  Shi-Wei Chu

发明人： Chi-Kuang Sun ,  Shi-Wei Chu

IPC分类号： G01N21/63 ,  G01N21/64 ,  G02B21/06 ,  G02B21/36 ,  G02F1/37 ,  G01B9/04

CPC分类号： G02B21/06 ,  G01N21/636 ,  G02B21/365

摘要： A harmonic generation microscopy employs a laser device that emits a laser beam having a predetermined wavelength that causes no autofluorescence in a biological sample and that, after excited, induces both the second and third harmonic waves. The laser beam is projected onto a sample and an observation beam from the sample is received. The observation beam is directed through a splitter to separate the second harmonic wave and the third harmonic wave both of which are then converted into corresponding electrical signals. The electrical signals are fed to a computer-based image processing equipment to form an image of the sample on the basis of the second and third harmonic waves.

公开(公告)号：US08941087B2

公开(公告)日：2015-01-27

申请号：US13170518

申请日：2011-06-28

申请人： Chi-Kuang Sun ,  Ming-Rung Tsai

发明人： Chi-Kuang Sun ,  Ming-Rung Tsai

IPC分类号： G01N21/86 ,  G01V8/00 ,  G02B21/00

CPC分类号： G02B21/00 ,  G02B21/002 ,  G02B2207/114

摘要： The present invention provides a plural third harmonic generation (THG) microscopic system and method. The system includes a laser device, a microscopic device, a beam splitter device and a photodetective device. By utilizing lasers with different central wavelengths or a broad band light source to simultaneously analyze THG response with respect to different wavelengths, a plurality of THG images and THG spectrum of the material or bio-tissue under stimulation of different wavelengths are obtained, thereby retrieving distributed microscopic images and resonant characteristics of the observational material or bio-molecules.

摘要翻译： 本发明提供一种三次谐波生成（THG）微观系统和方法。 该系统包括激光装置，微型装置，分束器装置和光电检测装置。 通过利用具有不同中心波长的激光器或宽带光源来同时分析相对于不同波长的THG响应，获得在不同波长刺激下的材料或生物组织的多个THG图像和THG光谱，从而检索分布 观察材料或生物分子的微观图像和共振特征。

公开(公告)号：US20130289370A1

公开(公告)日：2013-10-31

申请号：US13684408

申请日：2012-11-23

申请人： Chi-Kuang Sun ,  Yuan-Fu Tsai ,  Hua Chen

发明人： Chi-Kuang Sun ,  Yuan-Fu Tsai ,  Hua Chen

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/7246

摘要： The present invention provides a method for detecting a blood glucose level of a subject using an electromagnetic wave. Because a different blood glucose level is accompanied by a different electromagnetic absorption constant, the present invention compares a detected blood glucose electromagnetic absorption constant of the subject with data in a blood glucose electromagnetic absorption constant database so as to obtain a blood glucose concentration of the subject. The present invention also provides a device for detecting a blood glucose level of the subject using the electromagnetic wave.

摘要翻译： 本发明提供一种使用电磁波检测对象的血糖值的方法。 由于不同的血糖值伴随着不同的电磁吸收常数，因此本发明将检测出的血糖值电磁吸收常数与血糖值电磁吸收常数数据库中的数据进行比较，从而得到被检体的血糖浓度 。 本发明还提供一种使用电磁波检测对象的血糖值的装置。

公开(公告)号：US20130001408A1

公开(公告)日：2013-01-03

申请号：US13170518

申请日：2011-06-28

申请人： Chi-Kuang Sun ,  Ming-Rung Tsai

发明人： Chi-Kuang Sun ,  Ming-Rung Tsai

IPC分类号： G02B21/06

CPC分类号： G02B21/00 ,  G02B21/002 ,  G02B2207/114

摘要： The present invention provides a plural third harmonic generation (THG) microscopic system and method. The system includes a laser device, a microscopic device, a beam splitter device and a photodetective device. By utilizing lasers with different central wavelengths or a broad band light source to simultaneously analyze THG response with respect to different wavelengths, a plurality of THG images and THG spectrum of the material or bio-tissue under stimulation of different wavelengths are obtained, thereby retrieving distributed microscopic images and resonant characteristics of the observational material or bio-molecules.

摘要翻译： 本发明提供一种三次谐波生成（THG）微观系统和方法。 该系统包括激光装置，微型装置，分束器装置和光电检测装置。 通过利用具有不同中心波长的激光器或宽带光源来同时分析相对于不同波长的THG响应，获得在不同波长刺激下的材料或生物组织的多个THG图像和THG光谱，从而检索分布 观察材料或生物分子的微观图像和共振特征。