公开(公告)号：US20220401889A1

公开(公告)日：2022-12-22

申请号：US17776604

申请日：2020-11-20

申请人： Stichting voor de Technische Wetenschappen ,  UMC Utrecht Holding B.V. ,  Universiteit Utrecht Holding B.V. ,  Universiteit Twente

发明人： Dimitrios Stamatialis ,  Ilaria Geremia ,  Cornelus Franciscus van Nostrum ,  Karin Gerarda Frederika Gerritsen ,  Robert Smakman ,  Wilhelmus Everhardus Hennink ,  Jacobus Adrianus Wilhelmus Jong ,  Yong Guo

IPC分类号： B01D69/14 ,  B01D71/68 ,  B01J20/28 ,  B01D69/08 ,  B01D69/02 ,  B01D69/06 ,  B01D67/00 ,  B01D71/44

摘要： The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.

公开(公告)号：US20220137163A1

公开(公告)日：2022-05-05

申请号：US17517759

申请日：2021-11-03

申请人： Tesla Dynamic Coils BV ,  Futura Composites B.V. ,  UMC Utrecht Holding B.V.

发明人： Dennis Klomp ,  Stefan Zijlema ,  Catalina Arteaga De Castro ,  Martino Borgo

IPC分类号： G01R33/341 ,  G01R33/36

摘要： An MRI system receive coil arrangement 3 for use with a main MRI scanner arrangement. The arrangement includes at least one primary receive coil 6 having a first impedance at a predetermined frequency and a first size defined by a cross-sectional area bounded by the primary receive coil and at least one auxiliary receive coil 7 having a second impedance at said predetermined frequency and a second size defined by a cross-sectional area bounded by the auxiliary receive coil wherein the first impedance is lower than the second impedance and the first size is larger than the second size.

公开(公告)号：US20210404003A1

公开(公告)日：2021-12-30

申请号：US17362273

申请日：2021-06-29

申请人： THE JOHNS HOPKINS UNIVERSITY ,  UMC Utrecht Holding B.V.

发明人： Zachary Kaminsky ,  Marco Paul Maria Boks

IPC分类号： C12Q1/6883 ,  G01N33/92

摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3′ untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3′ UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm.

公开(公告)号：US11141198B2

公开(公告)日：2021-10-12

申请号：US15566315

申请日：2016-04-14

申请人： UMC UTRECHT HOLDING B.V.

发明人： Barbara Johanna Stefanie Van De Sande ,  Ralph Johan Bernhard Sakkers ,  Lucas Alphonsus Maria Evers

IPC分类号： A61B17/64 ,  A61B17/62

摘要： Coupling device for connecting an annular fixation member to a bone pin, wherein the coupling device comprises pin connecting means arranged for connecting the bone pin to the coupling device and ring connecting means arranged for removably connecting the annular fixation member to the coupling device, wherein the coupling device further comprises fixator connecting means arranged for removably connecting a fixator to the coupling device, wherein the ring connecting means and the fixator connecting means are arranged for simultaneously connecting the annular fixation member and the fixator while the pin connecting means are connected to the bone pin.

公开(公告)号：US11072828B2

公开(公告)日：2021-07-27

申请号：US15517215

申请日：2015-10-06

申请人： THE JOHNS HOPKINS UNIVERSITY ,  UMC Utrecht Holding B.V.

发明人： Zachary Kaminsky ,  Marco Paul Maria Boks

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12Q1/6883 ,  G01N33/92

摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3′ untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3′ UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm.

公开(公告)号：US20210179732A1

公开(公告)日：2021-06-17

申请号：US17132989

申请日：2020-12-23

申请人： UMC Utrecht Holding B.V.

发明人： Jeanette Henrica Wilhelmina LEUSEN ,  Johannes Gerardus Maria EVERS

IPC分类号： C07K16/30 ,  A61P35/00 ,  A61K31/203 ,  A61K38/19 ,  A61K39/395

摘要： The invention relates to anti-ganglioside GD2 antibodies that comprise an antibody variable domain and antibody constant domains, wherein the variable domain comprises a heavy and light chain variable region comprising respectively at least the CDR3 of the heavy chain variable region of antibody ch14.18 and at least the CDR3 of the light chain variable region of antibody ch14.18; and an IgA hinge and CH2 domain and to methods of treatment of subjects with a GD2 positive tumor, preferably neuroblastoma with these antibodies.

公开(公告)号：US11035852B2

公开(公告)日：2021-06-15

申请号：US16003293

申请日：2018-06-08

申请人： UMC Utrecht Holding B.V. ,  Koninklijke Nederlandse Akademie van Wetenschappen

发明人： Jeffrey Matthijn Beekman ,  Johanna Florentia Dekkers ,  Cornelis Korstiaan Van Der Ent ,  Johannes C. Clevers

IPC分类号： G01N33/50

摘要： The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.

公开(公告)号：US10726941B2

公开(公告)日：2020-07-28

申请号：US15309211

申请日：2015-04-22

申请人： Pirche AG ,  UMC Utrecht Holding B.V.

发明人： Ralf Schliehe-Diecks ,  Hendrikus Theodorus Spierings

IPC分类号： G16B20/00 ,  G01N33/68 ,  G01N33/569 ,  G16B99/00 ,  G16B20/30

摘要： The invention relates to a method, system and/or data structure for carrying out a computer implemented method for determining the numbers of predicted indirectly recognized HLA epitopes (PIRCHES) between one or more donors and one or more recipients of transplantation material. The method, system and data structure described herein allow the identification of permissible mismatches and therefore relatively safe transplantation material by analyzing via a computer implemented method HLA-derived peptides of patient and donor.

公开(公告)号：US10571542B2

公开(公告)日：2020-02-25

申请号：US15573599

申请日：2016-05-12

申请人： UMC UTRECHT HOLDING B.V.

发明人： Alessandro Sbrizzi ,  Cornelis Antonius Theodorus Van Den Berg ,  Annette Van Der Toorn

IPC分类号： G01R33/50 ,  G01R33/24 ,  G01R33/561

摘要： A system for performing time-domain magnetic resonance imaging includes an excitation device for transiently exciting a sample thereby causing the sample to emit an MRI signal. A receiving coil receives the MRI signal. A simulated signal of the receiving coil is generated in a time domain, based on a plurality of spatial parameter distributions, wherein the spatial parameter distributions include a spatial distribution of a magnetization, wherein the spatial parameter distributions further include at least one of a spatial distribution of a material property of a material of the sample and a spatial distribution of an electromagnetic field. An objective function is based on a difference between the received MRI signal and the simulated signal in the time domain. The plurality of spatial parameter distributions are fitted based on the objective function. The sample is excited again before the sample reaches an equilibrium state.

公开(公告)号：US20190383799A1

公开(公告)日：2019-12-19

申请号：US16003293

申请日：2018-06-08

申请人： UMC Utrecht Holding B.V. ,  Koninklijke Nederlandse Akademie van Wetenschappen

发明人： Jeffrey Matthijn Beekman ,  Johanna Florentia Dekkers ,  Cornelis Korstiaan Van Der Ent ,  Johannes C. Clevers

IPC分类号： G01N33/50

摘要： The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.