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    Phase-Domain Digitizer
    5.
    发明申请
    Phase-Domain Digitizer 有权
    相域数字化仪

    公开(公告)号：US20160087824A1

    公开(公告)日：2016-03-24

    申请号：US14544841

    申请日：2015-02-24

    申请人： Stichting voor de Technische Wetenschappen

    发明人： Kofi A. A. Makinwa ,  Rui Quan

    IPC分类号： H04L27/233 ,  H04L7/00

    CPC分类号： H04L27/2334 ,  G01F1/66 ,  H03L1/022 ,  H03L7/00 ,  H03L7/0814 ,  H03L7/085 ,  H03M3/412 ,  H03M3/464 ,  H03M3/496

    摘要： A phase-domain delta-sigma (ΔΣ) modulator in a phase digitizer determines a demodulated phase error based on a phase-modulated frequency signal, in which a carrier frequency is modulated with a fundamental frequency and an associated phase, and a selected one of a set of reference signals, where the demodulated phase error represents a difference between the phase and a reference phase of the selected one of the set of reference signals. Moreover, a digital filter in the phase-domain ΔΣ modulator filters the demodulated phase error. Furthermore, a latch in the phase-domain ΔΣ modulator provides a bit stream by sampling one or more bits of the filtered demodulated phase error, where an average value of the bit stream represents the phase. Next, control logic in the phase-domain ΔΣ modulator selects the one of the set of reference signals.

    摘要翻译： 相位数字化仪中的相位Δ-Σ（＆Dgr＆amp; Sgr）调制器基于相位调制频率信号确定解调的相位误差，其中以基频和相关相位对载波频率进行调制， 所选择的一组参考信号中的一个，其中解调的相位误差表示所述一组参考信号中的所选择的一个的相位和参考相位之间的差。 此外，相域中的数字滤波器＆Dgr; 调制器滤波解调的相位误差。 此外，相域中的锁存器＆Dgr; 调制器通过采样滤波的解调相位误差的一个或多个比特来提供比特流，其中比特流的平均值代表相位。 接下来，相域中的控制逻辑＆Dgr＆ 调制器选择该组参考信号中的一个。

    Method of fabricating a micro machined channel
    7.
    发明授权
    Method of fabricating a micro machined channel 有权

    公开(公告)号：US11629048B2

    公开(公告)日：2023-04-18

    申请号：US16647252

    申请日：2018-09-17

    申请人： BERKIN B.V. ,  UNIVERSITEIT TWENTE ,  STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN

    发明人： Yiyuan Zhao ,  Henk-Willem Veltkamp ,  Yaxiang Zeng ,  Joost Conrad Lötters ,  Remco John Wiegerink

    IPC分类号： B81C1/00

    摘要： The invention relates to a method of fabricating a micro machined channel, comprising the steps of providing a substrate of a first material and having a buried layer of a different material therein, and forming at least two trenches in said substrate by removing at least part of said substrate. Said trenches are provided at a distance from each other and at least partly extend substantially parallel to each other, as well as towards said buried layer. The method comprises the step of forming at least two filled trenches by providing a second material different from said first material and filling said at least two trenches with at least said second material; forming an elongated cavity in between said filled trenches by removing at least part of said substrate extending between said filled trenches; and forming an enclosed channel by providing a layer of material in said cavity and enclosing said cavity.

    THERMOSTABLE CAS9 NUCLEASES
    9.
    发明申请
    THERMOSTABLE CAS9 NUCLEASES 有权

    公开(公告)号：US20210340532A1

    公开(公告)日：2021-11-04

    申请号：US16469677

    申请日：2017-08-16

    申请人： Wageningen Universiteit ,  Stichting Voor De Technische Wetenschappen

    发明人： John Van Der Oost ,  Richard Van Kranenburg ,  Elleke Fenna Bosma ,  Ioannis Mougiakos ,  Prarthana Mohanraju

    IPC分类号： C12N15/113 ,  C12N9/22 ,  C12N15/90 ,  C12N15/10

    摘要： Thermostable Cas9 nucleases. The present invention relates to the field of genetic engineering and more particularly to nucleic acid editing and genome modification. The present invention provides an isolated Cas protein or polypeptide fragment thereof having an amino acid sequence of SEQ ID NO: 1 or a sequence of at least 77% identity therewith. The Cas protein or polypeptide is capable of binding, cleaving, marking or modifying a double stranded target polynucleotide at a temperature in the range 20° C. and 100° C. inclusive. The invention further provides isolated nucleic acid molecules encoding said Cas9 nucleases, expression vectors and host cells. The invention also provides PAM sequences recognized by the Cas protein or polypeptide, The Cas9 nucleases disclosed herein provide novel tools for genetic engineering in general, in particular at elevated temperatures and are of particular value in the genetic manipulation of thermophilic organisms; particularly microorganisms.