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公开(公告)号：US11981860B2
公开(公告)日：2024-05-14
申请号：US17661513
申请日：2022-04-29
申请人： UNIÃO BRASILEIRA DE EDUCAçÃO E ASSISTÊNCIA—MANTENEDORA DA PUCRS , PETRÓLEO BRASILEIRO S.A.—PETROBRAS
发明人： Gabriela Gonçalves Dias Ponzi , Felipe Dalla Vecchia , Sandra Mara De Oliveira Einloft , Marta Kerber Schütz , Victor Hugo Jacks Mendes Dos Santos , Darlan Pontin , Renan Bordulis Martel , Amanda Sofia De Guimarães E Stepanha , Dellyo Ricardo Dos Santos Alvares , Sonia Maria Cabral De Menezes , Ana Paula Santana Musse
IPC分类号： C04B7/13 , C04B7/40 , C04B7/52 , C04B28/02 , C09K8/42 , C09K8/493 , C04B111/00 , C04B111/22
CPC分类号： C09K8/493 , C04B7/13 , C04B7/40 , C04B7/522 , C04B7/527 , C04B28/02 , C09K8/426 , C04B2111/00275 , C04B2111/00663 , C04B2111/22 , C04B28/02 , C04B14/14 , C04B20/0076 , C04B20/008
摘要： The present invention describes a hydraulic cement composition, process and use thereof, wherein the composition comprises a hydraulic cement composition with increased resistance against carbon dioxide (CO2) for application in reservoirs such as oil and gas and carbon capture and storage (CCS) wells; with improved performance of cement paste formulations as a material for application in primary, secondary cementing, recovery and/or plugging operations, of reservoirs/wells that operate with high CO2 content; as a technological alternative to guarantee the integrity of wells in CO2-rich environments for long periods of time, without any additional intervention to the already current operational procedures for cementing wells, and with cost reduction in relation to class G cement (currently, the main raw material); and sufficient chemical resistance to carry out enhanced oil (EOR) and gas (EGR) recovery by injecting high levels of CO2, increasing reservoir pressure throughout the extraction period of hydrocarbon reservoirs.
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公开(公告)号：US20240279530A1
公开(公告)日：2024-08-22
申请号：US18628248
申请日：2024-04-05
申请人： União Brasileira de Educação E Assistência - Mantenedora da PUCRS , Petróleo Brasileiro S.A. - PETROBRAS
发明人： Gabriela GONÇALVES DIAS PONZI , Felipe DALLA VECCHIA , Sandra MARA DE OLIVEIRA EINLOFT , Marta Kerber SCHÜTZ , Victor Hugo JACKS MENDES DOS SANTOS , Darlan PONTIN , Renan Bordulis MARTEL , Amanda Sofia DE GUIMARÃES E STEPANHA , Dellyo Ricardo DOS SANTOS ALVARES , Sonia Maria CABRAL DE MENEZES , Ana Paula SANTANA MUSSE
IPC分类号： C09K8/493 , C04B7/13 , C04B7/40 , C04B7/52 , C04B28/02 , C04B111/00 , C04B111/22 , C09K8/42
CPC分类号： C09K8/493 , C04B7/13 , C04B7/40 , C04B7/522 , C04B7/527 , C04B28/02 , C09K8/426 , C04B2111/00275 , C04B2111/00663 , C04B2111/22
摘要： The present invention describes a hydraulic cement composition, process and use thereof, wherein the composition comprises a hydraulic cement composition with increased resistance against carbon dioxide (CO2) for application in reservoirs such as oil and gas and carbon capture and storage (CCS) wells; with improved performance of cement paste formulations as a material for application in primary, secondary cementing, recovery and/or plugging operations, of reservoirs/wells that operate with high CO2 content; as a technological alternative to guarantee the integrity of wells in CO2-rich environments for long periods of time, without any additional intervention to the already current operational procedures for cementing wells, and with cost reduction in relation to class G cement (currently, the main raw material); and sufficient chemical resistance to carry out enhanced oil (EOR) and gas (EGR) recovery by injecting high levels of CO2, increasing reservoir pressure throughout the extraction period of hydrocarbon reservoirs.
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3.发明申请COMPOUND, USE, ANTI-TUMOR PHARMACEUTICAL COMPOSITION,GENE CONSTRCT FOR POLYPEPTIDE EXPRESSION, PROCESS FOR THE PRODUCTION, PROCESS FOR THE EVALUATION OF TUMOR CELLS, METHOD OF SENSITIZATION OF TUMOR CELLS TO CHEMOTHERAPEUTIC 审中-公开化合物，用途，抗肿瘤药物组合物，用于多肽表达的基因组，生产过程，肿瘤细胞评价方法，肿瘤细胞对化学疗法的敏化方法公开(公告)号：US20160368955A1
公开(公告)日：2016-12-22
申请号：US14655608
申请日：2013-12-27
摘要： The use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. A gene construct for the expression of said protein; a production process; a process of evaluation of tumor cells; and a method of sensitization of tumors to chemotherapeutic agents. A new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells, in part as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.
摘要翻译： 使用HspBP1蛋白或其一部分制备抗肿瘤药物组合物，以及其与一种或多种化学治疗剂的任选组合。 用于表达所述蛋白质的基因构建体; 一个生产过程; 肿瘤细胞评估过程; 以及肿瘤对化学治疗剂敏化的方法。 一种新的体内和体外实验模型，用于开发/评估抗肿瘤剂。 药物组合物提供抗肿瘤作用并且对肿瘤细胞具有高特异性，导致对正常分化细胞的细胞毒性较小，部分作为目前已知的化学疗法治疗方案的缺点的解决方案。
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公开(公告)号：US09700547B2
公开(公告)日：2017-07-11
申请号：US14916152
申请日：2014-09-02
IPC分类号： A61K31/4412 , A61K31/513 , A61K31/4545
CPC分类号： A61K31/4412 , A61K31/4545 , A61K31/513 , A61K2300/00
摘要： The use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme, and the use of the compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein the inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics.
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5.发明申请USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME 有权6-羟基-2-吡啶酮及其衍生物的用途，用于制备通过抑制人尿磷酸酶酶的作用的药物组合物公开(公告)号：US20160193197A1
公开(公告)日：2016-07-07
申请号：US14916152
申请日：2014-09-02
IPC分类号： A61K31/4412 , A61K31/4545 , A61K31/513
CPC分类号： A61K31/4412 , A61K31/4545 , A61K31/513 , A61K2300/00
摘要： The use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme, and the use of the compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein the inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics.
摘要翻译： 使用至少一种式I或II化合物或其药学上可接受的盐来制备通过抑制磷酸化酶尿苷酶起作用的药物组合物，以及用于制备通过抑制人磷酸化酶起作用的药物组合物的用途 尿苷酶，其可以任选与至少一种抗肿瘤剂组合使用，其中所述抑制增加抗肿瘤药物的有效性并降低由施用抗肿瘤剂引起的副作用。
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