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公开(公告)号：US20220170019A1
公开(公告)日：2022-06-02
申请号：US17599463
申请日：2020-02-14
Applicant: SERVICIO ANDALUZ DE SALUD , UNIVERSIDAD DE MÁLAGA , UNIVERSIDAD DE SEVILLA , CIBER
Inventor： Said LHAMYANI , Adriana MARIEL GENTILE , Francisco José TINAHONES MADUEÑO , Rajaa EL BEKAY RIZKY , Rosa María GIRÁLDEZ PÉREZ , Elia María GRUESO MOLINA , Mª Pilar PÉREZ TEJEDA
IPC: C12N15/113 , A61K31/7105 , A61K47/00 , B82Y5/00
Abstract: The present invention relates to compositions, methods and uses, consisting of a functionalised miRNA-based nanosystem for treating obesity, weight loss and/or reduction of localised fat, which comprises miR-21 or other derived or equivalent compounds such as modified polynucleotides, synthetic mimetic and/or isomiR of miR-21; and a carrier which comprises an optimised nanoparticle for effectively binding oligonucleotides, forming an adequate nanosystem for in vivo transfection and, in particular, for the in vivo release of genes in fatty tissue.
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公开(公告)号：US11034031B2
公开(公告)日：2021-06-15
申请号：US16312860
申请日：2017-06-23
Applicant: FUNDACIÓN TECNALIA RESEARCH & INNOVATION , UNIVERSIDAD DE CÓRDOBA , SERVICIO ANDALUZ DE SALUD , UNIVERSIDAD DE MÁLAGA
Inventor： Julius Klein Hubert , Asier Fernández Iribar , Rafael Medina Carnicer , Rafael Muñoz Salinas , Enrique Bauzano Núñez , Mᵃ Carmen López Casado , Víctor Fernando Muñoz Martínez , María José Requena Tapia , José Eduardo Arjona Berral , Rosa María Paredes Esteban , Ángel Salvatierra Velázquez , Ignacio Muñoz Carvajal , Javier Briceño Delgado
Abstract: A tool coupling includes a first tool part and a second tool part, the second tool part being movable in relation to the first tool part. The tool coupling further includes a first base part for detachably retaining the first tool part and a second base part movable in relation to the first base part for detachably retaining the second tool part. The first base part has a pusher movable in relation to the first base part for detaching the first tool part and the second base part has a cap movable in relation to the second base part for detaching the second tool part.
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公开(公告)号：US20200055808A1
公开(公告)日：2020-02-20
申请号：US16329153
申请日：2017-08-29
Applicant: SERVICIO ANDALUZ DE SALUD , UNIVERSIDAD DE MÁLAGA
Inventor： María Isabel MONTAÑEZ VEGA , Cristobalina MAYORGA MAYORGA , Maria José TORRES JAEN , Tahía Diana FERNÁNDEZ DUARTE , Adriana ARIZA VEGUILLAS , María SALAS CASINELLO , Ezequiel PÉREZ DE INESTROSA VILLATORO , Francisco NÁJERA ALBENDÍN , Nekane BARBERO OLMOS , Yolanda VIDA POL
IPC: C07C69/96 , C07D207/46 , C07D498/04 , G01N33/50 , G01N33/68 , A61K31/265 , A61K31/424 , A61K31/40 , A61K9/08
Abstract: The authors of the present invention describe compounds derived from or structures related to clavulanic acid and the medical uses thereof. The invention also relates to a composition, a dosage form, a kit or device, and the uses of same.
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公开(公告)号：US12025830B2
公开(公告)日：2024-07-02
申请号：US17837774
申请日：2022-06-10
Inventor： David González Andrade , Aitor Villafranca Velasco , Pedro Corredera Guilén , J. Gonzalo Wangüemert Pérez , Alejandro Ortega Moñux , Robert Halir , Iñigo Molina Fernández
IPC: G02B6/12 , G02B6/124 , G02B6/125 , G02B6/14 , G02B6/28 , G02B6/34 , G02F1/01 , G02F1/21 , G02F1/225 , G02B6/122
CPC classification number: G02B6/12004 , G02B6/12007 , G02B6/124 , G02B6/125 , G02B6/14 , G02B6/2813 , G02B6/34 , G02F1/011 , G02F1/217 , G02F1/225 , G02B2006/12088 , G02B2006/1209 , G02B2006/12152 , G02B2006/12164 , G02B6/1228
Abstract: An integrated mode converter and multiplexer (/demultiplexer) combines a multimode interference coupler, at least one phase-shifter and a symmetrical Y-junction. The dispersion of the multimode interference coupler is engineered through subwavelength structures in order to achieve a very wide bandwidth. Several phase-shifter topologies for further bandwidth enhancement are disclosed, as well as architectures for multiplexing a greater number of optical modes.
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公开(公告)号：US11131809B2
公开(公告)日：2021-09-28
申请号：US16966678
申请日：2019-01-24
Inventor： Aitor Villafranca Velasco , Alaine Herrero Bermello , Pedro Corredera , Robert Halir , Alejandro Ortega Moñux , J. Gonzalo Wangüemert Pérez , Inigo Molina Fernández
Abstract: The invention relates to an integrated polarisation splitter based on a sub-wavelength multimode interference coupler (110), in other words, a multimode interference coupler (110) with an anisotropic multimode waveguide region formed by a plurality of sections of core material (210) and a plurality of sections of a cladding material (230) alternately arranged in a periodic way, with a period (Λ) smaller than the wavelength of a light propagated through said anisotropic region. The core material sections (210) are rotated an angle (α) greater than zero with respect to a perpendicular with an input waveguide (120) to increase the anisotropic character of the multimode waveguide region.
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Patent Agency Ranking
公开(公告)号：US20200225412A1
公开(公告)日：2020-07-16
申请号：US16650449
申请日：2018-09-24
Inventor： David GONZÁLEZ ANDRADE , Aitor VILLAFRANCA VELASCO , Pedro CORREDERA GUILÉN , J. Gonzalo WANGÜEMERT PÉREZ , Alejandro ORTEGA MOÑUX , Robert HALIR , Iñigo MOLINA FERNÁNDEZ
Abstract: An integrated mode converter and multiplexer (/demultiplexer) is disclosed, which combines a multimode interference coupler (100), at least one phase-shifter (200) and a symmetrical Y-junction (300). The dispersion of the multimode interference coupler (100) is engineered through subwavelength structures in order to achieve a very wide bandwidth. Several phase-shifter (200) topologies for further bandwidth enhancement are disclosed, as well as architectures for multiplexing a greater number of optical modes.
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公开(公告)号：US20170293471A1
公开(公告)日：2017-10-12
申请号：US15300049
申请日：2015-03-27
Applicant: UNIVERSIDAD DE MÁLAGA
CPC classification number: G06F7/523 , G06F7/483 , G06F7/485 , G06F7/487 , G06F7/49947 , G06F7/50 , G06F7/5443
Abstract: Devices for adding floating point numbers, devices for multiplying floating point numbers, devices for floating-point fused multiply-add operations, devices for performing fixed point number operations, and associated converters thereof. A preprocessed fixed point format is a fixed point format wherein the LSD of all numbers exactly represented in said format is equal to B/2 (i.e. one for binary radix), and the rest are rounded to one of these numbers. A preprocessed floating point format is a floating point format wherein the significand is a preprocessed fixed point number.
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公开(公告)号：US20240200760A1
公开(公告)日：2024-06-20
申请号：US18580540
申请日：2022-05-13
Applicant: UNIVERSIDAD DE MÁLAGA , UNIVERSIDAD DE ALCALÁ , SERVICIO ANDALUZ DE SALUD
Inventor： Enrique NAVARRETE DE GÁLVEZ , José AGUILERA ARJONA , Pablo FONDA PASCUAL , María Victoria DE GÁLVEZ ARANDA , Alfonso GAGO CALDERÓN , Enrique HERRERA CEBALLOS , José Ramón DE ANDRÉS DÍAZ , Santiago VIDAL ASENSI
IPC: F21V21/26 , F21Y113/13 , F21Y115/10
CPC classification number: F21V21/26 , F21Y2113/13 , F21Y2115/10
Abstract: The present invention relates to a lighting device comprising a plurality of LED diodes (1), installed and distributed on at least one support arm (2), all the LED diodes (1) being oriented towards a single treatment point (3) and the emitted light (8) of said diodes being focused towards said treatment point (3) by means of light-concentrating means (4). In this manner, it is possible to carry out localised treatments of photodynamic therapy, without affecting the healthy surface, adapting the dose to the requirements of the lesioned surface.
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公开(公告)号：US20240004261A1
公开(公告)日：2024-01-04
申请号：US18039828
申请日：2021-12-01
Applicant: UNIVERSIDAD DE MÁLAGA
Inventor： Abdelfettah HADIJ EL HOUATI , Inigo MOLINA FERNANDEZ , Juan Gonzalo WANGUEMERT PÉREZ , Alejandro ORTEGA MOÑUX , Robert HALIR
IPC: G02F1/313
CPC classification number: G02F1/313 , G02F2201/305 , G02F2202/30
Abstract: The invention relates to single-beam side deflectors with effective refractive indexes of respective channel and target film waveguides, a refractive index of the cladding and substrate, and a periodicity Λ of the channel waveguide that satisfy the single-beam diffraction conditions. The invention also relates to wavelength multiplexers/demultiplexers, optical antenna feeders, and methods which use all of them.
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10.发明授权公开(公告)号：US10059998B2
公开(公告)日：2018-08-28
申请号：US15125714
申请日：2015-03-13
Applicant: UNIVERSIDAD DE MÁLAGA , SERVICIO ANDALUZ DE SALUD , FUNDACIÓN PÚBLICA ANDALUZA PARA LA INVESTIGACIÓN DE MÁLAGA EN BIOMEDICINA Y SALUD (FIMABIS)
Inventor： José Lozano Castro , Emilio Alba Conejo , Luis Gustavo Pérez Rivas , José Jerez Aragonés , Nuria Ribelles Entrena
IPC: A61K48/00 , C07H21/02 , C07H21/04 , C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/166 , C12Q2600/178
Abstract: The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of particular miRNAs. Specifically, the invention relates to a method for determining the risk of recurrence of breast cancer which comprises measuring the expression levels of at least one miRNA selected from the group consisting of miR-149-5p (SEQ ID NO: 1), miR-10a-5p, (SEQ ID NO: 2), miR-20b-5p, (SEQ ID NO: 3), miR-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumor, wherein a change in the expression level of at least one miRNA in the tumor with respect to the expression level in a control sample is indicative of a high risk of recurrence of the tumor. The invention also relates to tools and kits for carrying out the method of the invention.
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