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公开(公告)号：US12150449B2
公开(公告)日：2024-11-26
申请号：US17056183
申请日：2018-12-28
Inventor： Alejandro Dinamarca , Claudia Ibacache , Juan Ojeda , Natalia Romo
Abstract: The invention relates to a method for obtaining a bacterial extract produced by the bacteria Kocuria marina sp., which prevents biofilm formation, to said extract, and to the use thereof for incorporation into natural or synthetic polymers intended to form structures with active surfaces for preventing microbial biofilm formation, whether for biomedical uses, including clinical uses, industrial uses, or even domestic uses.
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Patent Agency Ranking
公开(公告)号：US11357737B2
公开(公告)日：2022-06-14
申请号：US15579886
申请日：2016-06-04
Inventor： Elisa Zuñiga , Pablo Muñoz , Osvaldo Rubilar
IPC: A61K9/70 , A61K31/722 , A23L33/10 , A61P25/28 , A61K9/00 , A61K31/192 , A61K31/353 , A61K31/366 , A61K31/375 , A61K47/36
Abstract: The invention relates to self-assembled nanofibers of chitosan and bioactive compounds for use as nutraceuticals or drugs. Suitable bioactive compounds include molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls. The nanofibers are absorbed, without degradation, in the small intestine, containing and protecting the bioactive compounds until they reach target organs. The nanofibers also cross the blood-brain barrier, allowing the compounds to reach the brain where they act as a controlled release system. If the bioactive compounds are neuroprotectors, the nanofibers can treat or prevent neurodegenerative diseases, strokes and other diseases related to aging or associated with oxidative stress. The invention also relates to a method for obtaining the nanofibers involving mixing chitosan with the bioactive compounds and allowing self-assembly. The invention further relates to a dosage form containing the nanofibers, particularly for oral administration.
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公开(公告)号：US20210289792A1
公开(公告)日：2021-09-23
申请号：US17056183
申请日：2018-12-28
Inventor： Alejandro Dinamarca , Claudia Ibacache , Juan Ojeda , Natalia Romo
Abstract: The invention relates to a method for obtaining a bacterial extract produced by the bacteria Kocuria marina sp., which prevents biofilm formation, to said extract, and to the use thereof for incorporation into natural or synthetic polymers intended to form structures with active surfaces for preventing microbial biofilm formation, whether for biomedical uses, including clinical uses, industrial uses, or even domestic uses.
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4.发明申请公开(公告)号：US20200308619A1
公开(公告)日：2020-10-01
申请号：US16643823
申请日：2018-08-30
Applicant: UNIVERSIDAD DE VALPARAISO
Inventor： Alejandro DINAMARCA , Natalia ROMO , Claudia IBACACHE
IPC: C12Q1/02
Abstract: The invention relates to a gene construct for detecting the presence of microorganisms that produce chemical molecules of the Acyl-homoserine lactone (AHL) type, comprising a first expression cassette that includes a copper-inducible promoter operably linked to the gene encoding the RhlR protein and, downstream of said first expression cassette, a second expression cassette including a promoter that is induced by the AHL-RhlR complex, said promoter being operably linked to a gene encoding a reporter protein. The invention also includes a genetically modified biosensor cell to detect the presence of microorganisms comprising said gene construct, as well as the method of detecting the presence of microorganisms that produce AHL-type chemical molecules by immobilizing the biosensor in an organic matrix, generating a surface that can be used to expose a sample of a fluid such as air or a liquid medium, and thus detect these molecules mediated by the biosensor cell.
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公开(公告)号：US20230138227A1
公开(公告)日：2023-05-04
申请号：US17904958
申请日：2020-02-25
Inventor： Karoll Andriettee GONZALEZ PIZARRO , Miguel Alejandro DINAMARCA TAPIA , Claudia Jimena IBACACHE QUIROGA
IPC: A23C9/127
Abstract: A group of microorganisms, composed of Lactobacillus sp. strain K03D08, Bacillus sp. strain K03B01 and Kazachstania sp. strain K03K02G, which allows the hydrolysis of casein in different dairy products and the production of short-chain fatty acids and hydroxylated short-chain fatty acids; a process for obtaining a casein-free dairy derivative and enriched in short-chain fatty acids and hydroxylated short-chain fatty acids using the aforementioned microorganisms; compositions containing the microorganisms; and the production method of each of the microorganisms.
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公开(公告)号：US20180169031A1
公开(公告)日：2018-06-21
申请号：US15579886
申请日：2016-06-04
Inventor： Elisa ZUÑIGA , Pablo MUÑOZ , Osvaldo RUBILAR
IPC: A61K9/70 , A61K31/192 , A61K31/353 , A61K31/366 , A61P25/28 , A61K31/375 , A61K47/36 , A61K9/00 , A23L33/10
CPC classification number: A61K9/70 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/7007 , A61K31/192 , A61K31/353 , A61K31/366 , A61K31/375 , A61K31/722 , A61K47/36 , A61P25/28
Abstract: The invention relates to self-assembled nanofibers of chitosan and bioactive compounds for use as nutraceuticals or drugs. Suitable bioactive compounds include molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls. The nanofibers are absorbed, without degradation, in the small intestine, containing and protecting the bioactive compounds until they reach target organs. The nanofibers also cross the blood-brain barrier, allowing the compounds to reach the brain where they act as a controlled release system. If the bioactive compounds are neuroprotectors, the nanofibers can treat or prevent neurodegenerative diseases, strokes and other diseases related to aging or associated with oxidative stress. The invention also relates to a method for obtaining the nanofibers involving mixing chitosan with the bioactive compounds and allowing self-assembly. The invention further relates to a dosage form containing the nanofibers, particularly for oral administration.
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