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公开(公告)号：US20210202074A1
公开(公告)日：2021-07-01
申请号：US17058788
申请日：2019-03-27
摘要： The present invention relates to a novel methodology for the field of brain images from Positron Emission Tomography (PET), likewise applicable to brain images from Single-Photon Emission Computer Tomography (SPECT) or another technique that makes it possible to generate images of brain metabolism, function or blood flow. This methodology arises from the need to improve the medical diagnosis of neurological disorders and from the need for objective, unbiased quantification of brain metabolism. The method is based on the spatial symmetry of the metabolism of the healthy human brain. Under this assumption, the entire healthy brain metabolism can be deduced from the metabolism of a single hemisphere of the brain.
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公开(公告)号：US20240327488A1
公开(公告)日：2024-10-03
申请号：US18191023
申请日：2023-03-28
IPC分类号： C07K14/705 , A61P35/00
CPC分类号： C07K14/705 , A61P35/00
摘要： The present invention provides mimetic peptides that modulate connexin-46 (Cx46), pharmaceutical compositions comprising said mimetic peptides, and methods for treating cancer comprising administering to a subject in need a therapeutically effective amount of the Cx46 mimetic peptide or the pharmaceutical composition containing a Cx46 mimetic peptide.
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公开(公告)号：US11424022B2
公开(公告)日：2022-08-23
申请号：US17058788
申请日：2019-03-27
摘要： The present invention relates to a novel methodology for the field of brain images from Positron Emission Tomography (PET), likewise applicable to brain images from Single-Photon Emission Computer Tomography (SPECT) or another technique that makes it possible to generate images of brain metabolism, function or blood flow. This methodology arises from the need to improve the medical diagnosis of neurological disorders and from the need for objective, unbiased quantification of brain metabolism. The method is based on the spatial symmetry of the metabolism of the healthy human brain. Under this assumption, the entire healthy brain metabolism can be deduced from the metabolism of a single hemisphere of the brain.
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4.发明申请公开(公告)号：US20170164622A1
公开(公告)日：2017-06-15
申请号：US15115485
申请日：2015-01-19
CPC分类号： A01N65/08 , A01N25/08 , A01N43/16 , A61K36/63 , Y02A50/339 , Y02A50/342 , Y02A50/343 , Y02A50/344 , Y02A50/348 , Y02A50/351
摘要： The aim of the invention is to provide a biocide composition which consists of a commercial natural olive leaf extract (olea europea) and a carrier which allows administering the plant extract in the beehive, preferably syrup (50% w/v sucrose dissolution) to inhibit the growth of the Paenibacillus larvae bacteria in all the phases of its biological cycle, both in its vegetative state and as a spore, along with Melissococcus plutomius and/or Nosema spp. achieving a curative treatment or the prophylaxis of the disease in the Apis mellifera larvae and adult bees. The active substance is preferably oleuropein, a secoiridoid glucoside, naturally present in plants of the Oleaceae family, although in lower concentrations.
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5.发明申请COMPOSITION COMPRISING A GLUCOCORTICOID AND A THIAZOLIDINEDIONE FOR INDUCING COMPELTE ADIPOGENIC DIFFERENTIATION OF MAMMALIAN STEM CELLS 审中-公开包含GLUCOCORTICOID和噻唑烷二酮的组合物，用于诱导MAMMALIAN干细胞的综合性分化分化公开(公告)号：US20140315870A1
公开(公告)日：2014-10-23
申请号：US14354040
申请日：2012-12-24
IPC分类号： A61K31/573 , A61K31/4439 , C12N5/077
CPC分类号： A61K31/573 , A61K31/4439 , A61K45/06 , C12N5/0653 , C12N2501/39 , C12N2501/999 , C12N2506/1353 , A61K2300/00
摘要： The present invention relates to the provision of a composition comprising a glucocorticoid and a thiazolidinedione for inducing adipogenic differentiation, thereby successfully generating functional stem cells, from non-differentiated embryonic or adult stem cells originating from humans or other mammals, special preference being given to human mesenchymal stem cells. The preferred glucocorticoid is dexamethasone and the preferred thiazolidinedione is rosiglitazone. However, the invention extends to the families of both compounds.
摘要翻译： 本发明涉及提供包含糖皮质激素和噻唑烷二酮用于诱导成脂分化的组合物，从而从源自人或其他哺乳动物的非分化胚胎或成体干细胞成功产生功能性干细胞，特别优选给予人 间充质干细胞。 优选的糖皮质激素是地塞米松，优选的噻唑烷二酮是罗格列酮。 然而，本发明扩展到两种化合物的族。
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6.发明公开公开(公告)号：US20240141297A1
公开(公告)日：2024-05-02
申请号：US18280093
申请日：2022-03-02
发明人： Flavio Carrión Arriagada , Sebastián Beltrán Vergara , Cristian Bergmann Muñoz , Patricio Manque Manque , Ute Wöehlbier
CPC分类号： C12N5/0663 , A61K35/28 , A61P1/00 , A61P37/06 , C07K14/47 , C12N5/10 , C12N15/86 , C12N2740/15043
摘要： The present invention provides Mesenchymal Stem Cells (MSC) genetically modified for overexpressing Pacer—a newly described autophagy protein—where these MSC have immunomodulatory effects. The invention also provides the method for obtaining the MSC overexpressing Pacer and pharmaceutical formulations comprising said cells.
The MSC according to the invention are useful in the treatment of diseases with inflammatory origin and/or component.-
公开(公告)号：US20220087270A9
公开(公告)日：2022-03-24
申请号：US15115485
申请日：2015-01-19
摘要： The aim of the invention is to provide a biocide composition which consists of a commercial natural olive leaf extract (olea europea) and a carrier which allows administering the plant extract in the beehive, preferably syrup (50% w/v sucrose dissolution) to inhibit the growth of the Paenibacillus larvae bacteria in all the phases of its biological cycle, both in its vegetative state and as a spore, along with Melissococcus plutomius and/or Nosema spp. achieving a curative treatment or the prophylaxis of the disease in the Apis mellifera larvae and adult bees. The active substance is preferably oleuropein, a secoiridoid glucoside, naturally present in plants of the Oleaceae family, although in lower concentrations.
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公开(公告)号：US11412741B2
公开(公告)日：2022-08-16
申请号：US15115485
申请日：2015-01-19
摘要： The aim of the invention is to provide a biocide composition which consists of a commercial natural olive leaf extract (olea europea) and a carrier which allows administering the plant extract in the beehive, preferably syrup (50% w/v sucrose dissolution) to inhibit the growth of the Paenibacillus larvae bacteria in all the phases of its biological cycle, both in its vegetative state and as a spore, along with Melissococcus plutomius and/or Nosema spp. achieving a curative treatment or the prophylaxis of the disease in the Apis mellifera larvae and adult bees. The active substance is preferably oleuropein, a secoiridoid glucoside, naturally present in plants of the Oleaceae family, although in lower concentrations.
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