公开(公告)号：US12012613B2

公开(公告)日：2024-06-18

申请号：US16961483

申请日：2019-01-11

Applicant: GENETHON ,  UNIVERSITE D'EVRY-VAL-D'ESSONE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Mario Amendola ,  Giulia Pavani

IPC: C12N5/0789 ,  A61K35/28 ,  C12N9/22 ,  C12N15/113

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N9/22 ,  C12N15/113 ,  C12N2310/20 ,  C12N2800/80

Abstract: The present invention relates to a genetically modified hematopoietic stem cell comprising, in at least one globin gene comprised in the genome thereof, at least one transgene encoding a therapeutic protein or a therapeutic ribonucleic acid, the said transgene being placed under the control of the endogenous promoter of the said globin gene.

公开(公告)号：US20210221710A1

公开(公告)日：2021-07-22

申请号：US17255533

申请日：2019-06-28

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'EVRY VAL D'ESSONE ,  CY CERGY PARIS UNIVERSITÉ

Inventor： Sophie PEULON-PAGE ,  Rana CHOUMANE

IPC: C02F1/469 ,  C02F1/66

Abstract: The present invention concerns a method for electrochemically depolluting an aqueous solution containing at least one heavy metal, said method comprising the following steps: a) a step of measuring the pH of the aqueous solution, optionally followed by a step of adapting said pH by adding a strong acid or a strong base, b) bringing said aqueous solution into contact with a reference electrode, a counter-electrode and a working electrode comprising a conductive substrate, c) applying a constant potential to the arrangement, as a result of which a film of at least one heavy metal oxide is formed on said working electrode, this step being capable of being repeated when the aqueous solution contains several heavy metals, and d) recovering a depolluted aqueous solution and said film.

公开(公告)号：US12195368B2

公开(公告)日：2025-01-14

申请号：US17255533

申请日：2019-06-28

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'EVRY VAL D'ESSONE ,  CY CERGY PARIS UNIVERSITÉ

Inventor： Sophie Peulon-Page ,  Rana Choumane

IPC: C02F1/469 ,  C02F1/461 ,  C02F1/62 ,  C02F1/66 ,  C02F101/20

Abstract: The present invention concerns a method for electrochemically depolluting an aqueous solution containing at least one heavy metal, said method comprising the following steps: a) a step of measuring the pH of the aqueous solution, optionally followed by a step of adapting said pH by adding a strong acid or a strong base, b) bringing said aqueous solution into contact with a reference electrode, a counter-electrode and a working electrode comprising a conductive substrate, c) applying a constant potential to the arrangement, as a result of which a film of at least one heavy metal oxide is formed on said working electrode, this step being capable of being repeated when the aqueous solution contains several heavy metals, and d) recovering a depolluted aqueous solution and said film.

公开(公告)号：US20200377857A1

公开(公告)日：2020-12-03

申请号：US16961483

申请日：2019-01-11

Applicant: GENETHON ,  UNIVERSITE D'EVRY - VAL- D'ESSONE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Mario AMENDOLA ,  Giulia PAVANI

IPC: C12N5/0789 ,  C12N9/22 ,  C12N15/113 ,  A61K35/28

Abstract: The present invention relates to a genetically modified hematopoietic stem cell comprising, in at least one globin gene comprised in the genome thereof, at least one transgene encoding a therapeutic protein or a therapeutic ribonucleic acid, the said transgene being placed under the control of the endogenous promoter of the said globin gene.