-
公开(公告)号：US08948838B2
公开(公告)日：2015-02-03
申请号：US13146245
申请日：2009-01-27
CPC分类号： A61B5/0531 , A61B5/444 , A61B5/685 , A61B2562/0209 , A61B2562/043
摘要： The present invention provides impedance data having an improved spatial resolution, both with regard to depth and lateral extension, which enables a detection of diseased skin conditions, such a malignant melanoma, at an early stage. Specifically, the present invention is implemented in a probe, medical devices and medical systems including such a probe, and methods using such a probe for measuring electrical impedance of tissue of a subject. A switching circuit is arranged for selectively activate electrode pairs of the probe in accordance with a predetermined activation scheme, the predetermined activation scheme including to activate adjacent electrodes in a successive manner, to gradually scan tissue of the subject at a first tissue depth so as to obtain a sequence of impedance signals from the tissue depth.
摘要翻译： 本发明提供了阻抗数据，其具有在深度和侧向延伸方面具有改进的空间分辨率，其使得能够在早期阶段检测患有疾病的皮肤状况（例如恶性黑素瘤）。 具体地说，本发明在包括这种探针的探针，医疗装置和医疗系统以及使用这种探针来测量受试者组织的电阻抗的方法中实现。 开关电路被布置为根据预定的激活方案选择性地激活探针的电极对，该预定的激活方案包括以连续方式激活相邻电极，以逐渐扫描第一组织深度的受试者组织，以便 从组织深度获得一系列阻抗信号。
-
2.发明授权Method and apparatus for measuring glucose in body fluids using sub-dermal body tissue impedance measurements 有权使用亚皮肤体组织阻抗测量法测量体液中的葡萄糖的方法和装置公开(公告)号：US09022932B2
公开(公告)日：2015-05-05
申请号：US10588551
申请日：2005-02-04
申请人： Stig Ollmar , Peter Aberg , Ulrik Birgersson , Fredrik Neiderud
发明人： Stig Ollmar , Peter Aberg , Ulrik Birgersson , Fredrik Neiderud
IPC分类号： A61B5/05 , A61B5/145 , A61B5/053 , A61B5/0402
CPC分类号： A61B5/14532 , A61B5/0402 , A61B5/053 , A61B5/0538 , A61B5/7278 , A61M5/1723 , A61M2230/201
摘要： A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.
摘要翻译： 一种用于通过测量身体组织的阻抗来测量受试者体液中的葡萄糖水平的方法和装置，具有两对电极，用于将电流注入体组织的两个电极和用于检测的两个电极 随之而来的身体组织的电压。 身体组织通常是亚皮肤或皮下组织。 身体组织的测量阻抗用于与直接确定的葡萄糖水平相关联，以从测量的阻抗确定葡萄糖水平。 因此，可以以可靠和可重复的方式确定体液葡萄糖水平。
-
公开(公告)号：US20110282180A1
公开(公告)日：2011-11-17
申请号：US13146245
申请日：2009-01-27
IPC分类号： A61B5/053
CPC分类号： A61B5/0531 , A61B5/444 , A61B5/685 , A61B2562/0209 , A61B2562/043
摘要： The present invention provides impedance data having an improved spatial resolution, both with regard to depth and lateral extension, which enables a detection of diseased skin conditions, such a malignant melanoma, at an early stage. Specifically, the present invention is implemented in a probe, medical devices and medical systems including such a probe, and methods using such a probe for measuring electrical impedance of tissue of a subject. A switching circuit is arranged for selectively activate electrode pairs of the probe in accordance with a predetermined activation scheme, the predetermined activation scheme including to activate adjacent electrodes in a successive manner, to gradually scan tissue of the subject at a first tissue depth so as to obtain a sequence of impedance signals from the tissue depth.
摘要翻译： 本发明提供了阻抗数据，其具有在深度和侧向延伸方面具有改进的空间分辨率，其使得能够在早期阶段检测患有疾病的皮肤状况（例如恶性黑素瘤）。 具体地说，本发明在包括这种探针的探针，医疗装置和医疗系统以及使用这种探针来测量受试者组织的电阻抗的方法中实现。 开关电路被布置为根据预定的激活方案选择性地激活探针的电极对，该预定的激活方案包括以连续方式激活相邻电极，以逐渐扫描第一组织深度的受试者组织，以便 从组织深度获得一系列阻抗信号。
-
4.发明授权公开(公告)号：US09636035B2
公开(公告)日：2017-05-02
申请号：US11302498
申请日：2005-12-14
申请人： Stig Ollmar , Ulrik Birgersson , Peter Aberg , Ingrid Nicander , Thierry Corman
发明人： Stig Ollmar , Ulrik Birgersson , Peter Aberg , Ingrid Nicander , Thierry Corman
CPC分类号： A61B5/0531 , A61B5/411 , A61B5/444 , A61B5/685
摘要： Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.
-
5.发明申请Method and apparatus for measuring glucose in body fluids using sub-dermal body tissue impedance measurements 有权使用亚皮肤体组织阻抗测量法测量体液中的葡萄糖的方法和装置公开(公告)号：US20070161881A1
公开(公告)日：2007-07-12
申请号：US10588551
申请日：2005-02-04
申请人： Stig Ollmar , Peter Aberg , Ulrik Birgersson , Fredrik Neiderud
发明人： Stig Ollmar , Peter Aberg , Ulrik Birgersson , Fredrik Neiderud
CPC分类号： A61B5/14532 , A61B5/0402 , A61B5/053 , A61B5/0538 , A61B5/7278 , A61M5/1723 , A61M2230/201
摘要： A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.
摘要翻译： 一种用于通过测量身体组织的阻抗来测量受试者体液中的葡萄糖水平的方法和装置，具有两对电极，用于将电流注入体组织的两个电极和用于检测的两个电极 随之而来的身体组织的电压。 身体组织通常是亚皮肤或皮下组织。 身体组织的测量阻抗用于与直接确定的葡萄糖水平相关联，以从测量的阻抗确定葡萄糖水平。 因此，可以以可靠和可重复的方式确定体液葡萄糖水平。
-
6.发明申请Medical apparatus for determination of biological conditions using impedance measurements 有权用于使用阻抗测量来确定生物学条件的医疗设备公开(公告)号：US20070135729A1
公开(公告)日：2007-06-14
申请号：US11302498
申请日：2005-12-14
申请人： Stig Ollmar , Ulrik Birgersson , Peter Aberg , Ingrid Nicander , Thierry Corman
发明人： Stig Ollmar , Ulrik Birgersson , Peter Aberg , Ingrid Nicander , Thierry Corman
IPC分类号： A61B5/05
CPC分类号： A61B5/0531 , A61B5/411 , A61B5/444 , A61B5/685
摘要： Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.
摘要翻译： 用于诊断受试者皮肤病变状况的医疗装置。 该装置包括一个包括多个电极的导电探针，每个电极包括多个微针，其中每个电极包括基底，所述微针与所述基底一体地形成并且以横向隔开的关系布置 彼此并且具有足以穿透角质层的长度，所述微针布置成至少部分倾斜的形状。 此外，本发明涉及用于该装置的电极，微针阵列和使用阻抗测量来诊断生物学条件的方法。 诊断特别涉及癌症，优选皮肤癌，其中皮肤癌是基底细胞癌，恶性黑素瘤，鳞状细胞癌或这种病变的前体。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.009 秒)
