公开(公告)号：US09636035B2

公开(公告)日：2017-05-02

申请号：US11302498

申请日：2005-12-14

申请人： Stig Ollmar ,  Ulrik Birgersson ,  Peter Aberg ,  Ingrid Nicander ,  Thierry Corman

发明人： Stig Ollmar ,  Ulrik Birgersson ,  Peter Aberg ,  Ingrid Nicander ,  Thierry Corman

IPC分类号： A61B5/05 ,  A61B5/053 ,  A61B5/00

CPC分类号： A61B5/0531 ,  A61B5/411 ,  A61B5/444 ,  A61B5/685

摘要： Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

公开(公告)号：US20100006536A1

公开(公告)日：2010-01-14

申请号：US12097448

申请日：2006-12-14

申请人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

发明人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

IPC分类号： B44C1/22

CPC分类号： A61M37/0015 ,  A61B5/053 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61N1/0502 ,  A61N1/0551 ,  H01L2224/48091 ,  H01L2224/8592 ,  H01L2924/00014

摘要： The invention relates in a general aspect to a method of making vertically protruding elements on a substrate, said elements having a tip comprising at least one inclined surface and an elongated body portion extending between said substrate and said tip. The method comprises an anisotropic, crystal plane dependent etch forming said inclined surface(s); and an anisotropic, non crystal plane dependent etch forming said elongated body portion; combined with suitable patterning processes defining said protruding elements to have a predetermined base geometry.

摘要翻译： 本发明在一般方面涉及在衬底上制造垂直突出元件的方法，所述元件具有包括至少一个倾斜表面的尖端和在所述基底和所述尖端之间延伸的细长主体部分。 该方法包括形成所述倾斜表面的各向异性的晶面依赖蚀刻; 以及形成所述细长主体部分的各向异性非晶面依赖蚀刻; 结合限定所述突出元件的合适的图案化工艺具有预定的基部几何形状。

公开(公告)号：US08308960B2

公开(公告)日：2012-11-13

申请号：US12097448

申请日：2006-12-14

申请人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

发明人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

IPC分类号： C25F3/00 ,  B44C1/22

CPC分类号： A61M37/0015 ,  A61B5/053 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61N1/0502 ,  A61N1/0551 ,  H01L2224/48091 ,  H01L2224/8592 ,  H01L2924/00014

摘要： The invention relates in a general aspect to a method of making vertically protruding elements on a substrate, said elements having a tip comprising at least one inclined surface and an elongated body portion extending between said substrate and said tip. The method comprises an anisotropic, crystal plane dependent etch forming said inclined surface(s); and an anisotropic, non crystal plane dependent etch forming said elongated body portion; combined with suitable patterning processes defining said protruding elements to have a predetermined base geometry.

摘要翻译： 本发明在一般方面涉及在衬底上制造垂直突出元件的方法，所述元件具有包括至少一个倾斜表面的尖端和在所述基底和所述尖端之间延伸的细长主体部分。 该方法包括形成所述倾斜表面的各向异性的晶面依赖蚀刻; 以及形成所述细长主体部分的各向异性非晶面依赖蚀刻; 结合限定所述突出元件的合适的图案化工艺具有预定的基部几何形状。

公开(公告)号：US08637351B2

公开(公告)日：2014-01-28

申请号：US13278890

申请日：2011-10-21

申请人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

发明人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

IPC分类号： H01L21/00

CPC分类号： A61M37/0015 ,  A61B5/053 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61N1/0502 ,  A61N1/0551 ,  H01L2224/48091 ,  H01L2224/8592 ,  H01L2924/00014

摘要： The invention relates in a general aspect to a method of making vertically protruding elements on a substrate, said elements having a tip comprising at least one inclined surface and an elongated body portion extending between said substrate and said tip. The method comprises an anisotropic, crystal plane dependent etch forming said inclined surface(s); and an anisotropic, non crystal plane dependent etch forming said elongated body portion; combined with suitable patterning processes defining said protruding elements to have a predetermined base geometry.

摘要翻译： 本发明在一般方面涉及在衬底上制造垂直突出元件的方法，所述元件具有包括至少一个倾斜表面的尖端和在所述基底和所述尖端之间延伸的细长主体部分。 该方法包括形成所述倾斜表面的各向异性的晶面依赖蚀刻; 以及形成所述细长主体部分的各向异性非晶面依赖蚀刻; 结合限定所述突出元件的合适的图案化工艺具有预定的基部几何形状。

公开(公告)号：US20120126392A1

公开(公告)日：2012-05-24

申请号：US13278890

申请日：2011-10-21

申请人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

发明人： Edvard Kälvesten ,  Thorbjörn Ebefors ,  Thierry Corman

IPC分类号： H01L23/48 ,  H01L21/78

CPC分类号： A61M37/0015 ,  A61B5/053 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61N1/0502 ,  A61N1/0551 ,  H01L2224/48091 ,  H01L2224/8592 ,  H01L2924/00014

摘要： The invention relates in a general aspect to a method of making vertically protruding elements on a substrate, said elements having a tip comprising at least one inclined surface and an elongated body portion extending between said substrate and said tip. The method comprises an anisotropic, crystal plane dependent etch forming said inclined surface(s); and an anisotropic, non crystal plane dependent etch forming said elongated body portion; combined with suitable patterning processes defining said protruding elements to have a predetermined base geometry.

摘要翻译： 本发明在一般方面涉及在衬底上制造垂直突出元件的方法，所述元件具有包括至少一个倾斜表面的尖端和在所述基底和所述尖端之间延伸的细长主体部分。 该方法包括形成所述倾斜表面的各向异性的晶面依赖蚀刻; 以及形成所述细长主体部分的各向异性非晶面依赖蚀刻; 结合限定所述突出元件的合适的图案化工艺具有预定的基部几何形状。

公开(公告)号：US20070135729A1

公开(公告)日：2007-06-14

申请号：US11302498

申请日：2005-12-14

申请人： Stig Ollmar ,  Ulrik Birgersson ,  Peter Aberg ,  Ingrid Nicander ,  Thierry Corman

发明人： Stig Ollmar ,  Ulrik Birgersson ,  Peter Aberg ,  Ingrid Nicander ,  Thierry Corman

IPC分类号： A61B5/05

CPC分类号： A61B5/0531 ,  A61B5/411 ,  A61B5/444 ,  A61B5/685

摘要： Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

摘要翻译： 用于诊断受试者皮肤病变状况的医疗装置。 该装置包括一个包括多个电极的导电探针，每个电极包括多个微针，其中每个电极包括基底，所述微针与所述基底一体地形成并且以横向隔开的关系布置 彼此并且具有足以穿透角质层的长度，所述微针布置成至少部分倾斜的形状。 此外，本发明涉及用于该装置的电极，微针阵列和使用阻抗测量来诊断生物学条件的方法。 诊断特别涉及癌症，优选皮肤癌，其中皮肤癌是基底细胞癌，恶性黑素瘤，鳞状细胞癌或这种病变的前体。