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公开(公告)号：US20240206487A1
公开(公告)日：2024-06-27
申请号：US18601033
申请日：2024-03-11
Applicant: Nanotec S.A. , Universidad Andrés Bello
Inventor： Marlene Arismendi-Macuer , Patricio Jarpa , Danilo González , Reinaldo Campos Vargas
Abstract: The present disclosure relates to the generation of food grade sugar modified 1-MCP nanobubbles ranging in size from 50 to 600 nm. These nanobubbles have a high degree of stability while in aqueous solution and can inhibit the action of ethylene in different biological processes. In addition, they can reduce the action of ethylene in plant metabolism, making the plant less susceptible to water stress, low temperature stress, and stress from soil conditions, among others. This disclosure also relates to the method of preparing sugar modified 1-MCP nanobubbles, their different uses and applications.
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公开(公告)号：US10449156B2
公开(公告)日：2019-10-22
申请号：US15328313
申请日：2014-07-23
Applicant: Universidad Andrés Bello
Inventor： Luis Velásquez , Reinaldo Campos , Danilo Gonzalez , Rubén Polanco
IPC: A01N25/10 , A01N25/18 , A01N25/28 , A01N27/00 , A01N31/04 , A61K9/48 , A61K9/50 , A01N25/22 , A01N31/06
Abstract: A controlled release system includes a polymeric support, wherein the polymeric support is biodegradable; a polymeric matrix, wherein the polymeric matrix includes polyhydroalkanoate; and encapsulated gases or volatiles; and a controlled release system includes a polymeric support; a polymeric matrix, wherein the polymeric matrix includes (poly-3-hydroxybutyrate-co-3-hydroxyvalerate) and poly (ε-caprolactone); and encapsulated gases or volatiles.
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公开(公告)号：US11331355B2
公开(公告)日：2022-05-17
申请号：US16348655
申请日：2016-11-09
Applicant: UNIVERSIDAD ANDRÉS BELLO
Inventor： Waldemar Mauricio Bittner Ortega , Pamela Isabel Machuca Valenzuela , Valeska Susana Herrera Sanhueza , Ignacio Andrés Fuentevilla Morgado
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from FnpΦ02-14, FnpΦ11 and FnnΦ107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as V periodontal disease, among others.
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公开(公告)号：US20200028445A1
公开(公告)日：2020-01-23
申请号：US16334942
申请日：2017-09-20
IPC: H02M7/487 , H02M7/00 , H02M7/5387
Abstract: A multilevel converter operating with fewer components saving costs, losses, size and weight, allowing the reduction of volume and accessibility to the control and transformation of electric power, comprising at least a basic cell formed by: a) a first power switch that interconnects the positive bus between said at least one basic cell and at least another basic cell connected in cascade each other and/or a basic cell and a continuous voltage source; b) a second power switch that interconnects the negative bus between said at least one basic cell and at least another basic cell connected in cascade each other; and/or a basic cell and the continuous voltage source of point a); and c) a capacitor with a third power switch, both of them being connected in series each other and interconnected between the positive and negative bus.
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公开(公告)号：US11957133B2
公开(公告)日：2024-04-16
申请号：US16818253
申请日：2020-03-13
Applicant: NANOTEC S.A. , Universidad Andrés Bello
Inventor： Marlene Arismendi-Macuer , Patricio Jarpa , Danilo González , Reinaldo Campos Vargas
Abstract: The present disclosure relates to the generation of food grade sugar modified 1-MCP nanobubbles ranging in size from 50 to 600 nm. These nanobubbles have a high degree of stability while in aqueous solution and can inhibit the action of ethylene in different biological processes. In addition, they can reduce the action of ethylene in plant metabolism, making the plant less susceptible to water stress, low temperature stress, and stress from soil conditions, among others. This disclosure also relates to the method of preparing sugar modified 1-MCP nanobubbles, their different uses and applications.
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Patent Agency Ranking
公开(公告)号：US20220096510A1
公开(公告)日：2022-03-31
申请号：US17268872
申请日：2018-08-17
Applicant: UNIVERSIDAD ANDRÉS BELLO
IPC: A61K31/7048 , A61K31/575 , A61K38/15 , A61P31/04
Abstract: Recurrent C. difficile infections are the major cause of death due to C. difficile, which is the causative agent of approximately 20% of antibiotic-associated diarrheas. Conventional treatments for C. difficile infections are not capable of eliminating the rates of recurrence, which occurs in 20-30% of the cases and may be repetitive, the probability of death being greater in each cycle. Until now, the persistence mechanisms of C. difficile for producing recurrence conditions were unknown. In the present invention, we describe the mechanism by which C. difficile spores persist, and a method of treatment with a pharmacological composition based on an antibiotic and nystatin for preventing recurrent C. difficile infections. The route of administration of nystatin is also protected (i.e., oral, intraperitoneal).
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公开(公告)号：US20200054699A1
公开(公告)日：2020-02-20
申请号：US16348655
申请日：2016-11-09
Applicant: UNIVERSIDAD ANDRÉS BELLO
Inventor： Mauricio Waldemar BITTNER ORTEGA , Pamela Isabel MACHUCA VALENZUELA , Valeska Susana HERRERA SANHUEZA , Ignacio Andrés FUENTEVILLA MORGADO
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from FnpΦ02-14, FnpΦ11 and FnnΦ107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as V periodontal disease, among others.
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公开(公告)号：US11654167B2
公开(公告)日：2023-05-23
申请号：US17236645
申请日：2021-04-21
Applicant: UNIVERSIDAD ANDRÉS BELLO
Inventor： Waldemar M. Bittner Ortega , Pamela I. Machuca Valenzuela , Valeska S. Herrera Sanhueza , Ignacio A. Fuentevilla Morgado
CPC classification number: A61K35/76 , A61K9/0053 , A61P31/04
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from FnpΦ02-14, FnpΦ11 and FnnΦ107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as periodontal disease, among others.
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公开(公告)号：US20210299196A1
公开(公告)日：2021-09-30
申请号：US17236645
申请日：2021-04-21
Applicant: UNIVERSIDAD ANDRÉS BELLO
Inventor： Waldemar M. Bittner Ortega , Pamela I. Machuca Valenzuela , Valeska S. Herrera Sanhueza , Ignacio A. Fuentevilla Morgado
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from FnpΦ02-14, FnpΦ11 and FnnΦ107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as periodontal disease, among others.
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公开(公告)号：US11018600B2
公开(公告)日：2021-05-25
申请号：US16334942
申请日：2017-09-20
IPC: H02M7/00 , H02M7/487 , H02M7/5387
Abstract: A multilevel converter allowing the reduction of volume and accessibility to the control and transformation of electric power, including at least two basic cells and having: a) a first power switch that interconnects a positive bus between the two basic cells connected in cascade each other; b) a second power switch that interconnects a negative bus between two basic cells connected in cascade each other and c) a capacitor with a third power switch, connected in series and interconnected between the positive and negative bus.
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