公开(公告)号：US20240053199A1

公开(公告)日：2024-02-15

申请号：US18257317

申请日：2020-12-17

Applicant: Università degli Studi di Bari Aldo Moro

Inventor： Milena D'ANGELO ,  Augusto GARUCCIO ,  Gianlorenzo MASSARO ,  Francesco Vincenzo PEPE

IPC: G01J3/28 ,  G01J3/02

CPC classification number: G01J3/2823 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/2803

Abstract: A hyperspectral imaging device and method disclosed herein overcomes the technical problems associated with the prior art by replacing the intensity measurement performed by the single high-resolution 2D sensor of state-of-the-art methodologies, with the measurement of intensity (fluctuation) correlations retrieved by two high-resolution 2D sensors: one—the imaging/spatial sensor dedicated to polychromatic image acquisition, the other—the spectral sensor dedicated to pure spectral measurement. In the hyperspectral correlation imaging disclosed herein, the spectral information is encoded into the intensity correlation without requiring any spectral scanning. Even though multiple exposures (frames) are generally required to reconstruct light statistics and perform correlation measurements, the exposure times are several orders of magnitude shorter than those required in the scanning approach. In addition, no changes of the device are required during such multiple exposures, which simplifies the optics/optomechanics of the device and avoids further time consumption.

公开(公告)号：US12036201B2

公开(公告)日：2024-07-16

申请号：US17043955

申请日：2019-03-28

Applicant: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO

Inventor： Loreto Gesualdo ,  Paola Pontrelli

IPC: A61K31/345 ,  A61K31/277 ,  A61K31/351 ,  A61K31/403 ,  A61P3/10 ,  A61P13/12

CPC classification number: A61K31/345 ,  A61K31/277 ,  A61K31/351 ,  A61K31/403 ,  A61P3/10 ,  A61P13/12

Abstract: The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.

公开(公告)号：US12007356B2

公开(公告)日：2024-06-11

申请号：US16963885

申请日：2018-01-26

Applicant: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO

Inventor： Luisa Torsi ,  Gaetano Scamarcio ,  Eleonora Macchia ,  Kyriaki Manoli ,  Gerardo Palazzo ,  Nicola Cioffi ,  Rosaria Anna Picca

IPC: G01N27/414 ,  G01N33/543

CPC classification number: G01N27/4148 ,  G01N27/4145 ,  G01N33/5438

Abstract: A field effect transistor sensor includes: a source-drain channel, a semiconductor layer on said source-drain channel, a first gate electrode arranged above said semiconductor layer, a first well enclosing said source-drain channel, said semiconductor layer and said first gate electrode, the first well being configured to be filled, in use, with a first liquid, particularly a gating electrolyte, a second gate electrode arranged above the first gate electrode and exposed to an interior of the first well. Also disclosed is an array device including an array of field effect transistor sensors according to the above.

公开(公告)号：US20210015785A1

公开(公告)日：2021-01-21

申请号：US17043955

申请日：2019-03-28

Applicant: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO

Inventor： Loreto GESUALDO ,  Paola PONTRELLI

IPC: A61K31/345 ,  A61P13/12 ,  A61P3/10 ,  A61K31/403 ,  A61K31/7048

Abstract: The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.

公开(公告)号：US20200348259A1

公开(公告)日：2020-11-05

申请号：US16963885

申请日：2018-01-26

Applicant: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO

Inventor： Luisa TORSI ,  Gaetano SCAMARCIO ,  Eleonora MACCHIA ,  Kyriaki MANOLI ,  Gerardo PALAZZO ,  Nicola CIOFFI ,  Rosaria Anna PICCA

IPC: G01N27/414 ,  G01N33/543

Abstract: A field effect transistor sensor includes: a source-drain channel, a semiconductor layer on said source-drain channel, a first gate electrode arranged above said semiconductor layer, a first well enclosing said source-drain channel, said semiconductor layer and said first gate electrode, the first well being configured to be filled, in use, with a first liquid, particularly a gating electrolyte, a second gate electrode arranged above the first gate electrode and exposed to an interior of the first well. Also disclosed is an array device including an array of field effect transistor sensors according to the above.