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    Optical fibre curvature sensor and measurement device comprising said sensor
    3.
    发明授权
    Optical fibre curvature sensor and measurement device comprising said sensor 有权

    公开(公告)号：US11131544B2

    公开(公告)日：2021-09-28

    申请号：US16087290

    申请日：2017-03-23

    申请人： Université de Nantes ,  Centre National de la Recherche Scientifique

    发明人： Romain Guyard ,  Yann Lecieux ,  Cyril Lupi ,  Dominique Leduc

    IPC分类号： G01B11/255 ,  G01B11/16

    摘要： An optical fiber curvature sensor. Two networks (R1, R2) with periodic longitudinal modulation of the refractive index of the optical fiber core are inscribed in the fiber (F) one behind the other or one on top of the other. The networks are configured to respectively reflect wavelengths λ1 and λ2 such that λ1=λB+ΔλB1 and λ2=λB+ΔλB2, where λB is the Bragg wavelength of the networks and where λB1 and λB2 are shifts sensitive to the temperature, to deformations and to the curvature of the optical fiber. The two networks are defined so that the quantities ΔλB1 and ΔλB2 have substantially identical sensitivity to temperature and to deformations and substantially opposite sensitivity to curvature.

    METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS
    5.
    发明申请
    METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS 审中-公开

    公开(公告)号：US20200319164A1

    公开(公告)日：2020-10-08

    申请号：US16303771

    申请日：2017-05-24

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITÉ DE NANTES ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

    发明人： Carole GUILLONNEAU ,  David LAPLAUD ,  Séverine BEZIE ,  Bryan NICOL

    IPC分类号： G01N33/50 ,  G01N33/68

    摘要： The present invention relates to methods for detecting, assessing severity and treating multiple sclerosis. The inventors showed an impairment of the function of CD8+ Treg cells in MS patients and they demonstrated here that several criteria correlated with the disease severity i.e. the percentage of CD8+CD45RCintCD161lowValpha7− T cells in the blood, the secretion of IFNg and IL10 and the suppressive activity of the CD8+CD45RCintCD161lowValpha7− T cells. In particular, the present invention relates to a method for determining whether a subject has or is at risk of having multiple sclerosis comprising i) determining the percentage of CD8+CD45RCintCD161lowValpha7− T cells in a biological sample obtained from the subject, ii) comparing the percentage determined at step i) with a predetermined reference value and iii) detecting differential in the percentage determined at step i) with the predetermined reference value indicates that the subject has or is at risk of having multiple sclerosis.

    OPTICAL FIBRE CURVATUR SENSOR AND MEASUREMENT DEVICE COMPRISING SAID SENSOR
    6.
    发明申请
    OPTICAL FIBRE CURVATUR SENSOR AND MEASUREMENT DEVICE COMPRISING SAID SENSOR 审中-公开

    公开(公告)号：US20200240771A1

    公开(公告)日：2020-07-30

    申请号：US16087290

    申请日：2017-03-23

    申请人： Université de Nantes ,  Centre National de la Recherche Scientifique

    发明人： Romain GUYARD ,  Yann LECIEUX ,  Cyril LUPI ,  Dominique LEDUC

    IPC分类号： G01B11/255 ,  G01B11/16

    摘要： An optical fiber curvature sensor. Two networks (R1, R2) with periodic longitudinal modulation of the refractive index of the optical fiber core are inscribed in the fiber (F) one behind the other or one on top of the other. The networks are configured to respectively reflect wavelengths λ1 and λ2 such that λ1=λB+ΔλB1 and λ2=λB+ΔλB2, where λB is the Bragg wavelength of the networks and where λB1 and λB2 are shifts sensitive to the temperature, to deformations and to the curvature of the optical fiber. The two networks are defined so that the quantities ΔλB1 and ΔλB2 have substantially identical sensitivity to temperature and to deformations and substantially opposite sensitivity to curvature.